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How toxic is Mephedrone?

yeah why would someone inject over ten times more than they were gonna swallow, it doesn't make sense, if you were gonna inject loads why swallow any at all?
 
Has anyone on SSRI's given this stuff a shot?

I am not on SSRI's, but have been in the past and may possibly go back on them. I don't roll often, but I do like to once in a while and if I am being medicated the opportunity to roll will obviously be taken away. So I was wondering about any interactions between Meph and SSRI's. Is it safe to combine? Will the meph still have an effect? Thanks.
 
mugabe said:
so could short term stimulant use for 2 or 3 hours a day maximum replace the need for cardio exercise. Quite interesting if this is true. I know it wouldn't help build up other muscles other than the heart.
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Yes, sittting down and doing stimulants is a great way to keep the heart healthy. Even better than a bowl of shreddies 8)
 
shoolameet said:
Has anyone on SSRI's given this stuff a shot?
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Really not a good idea mate, the effects are greatly blunted and it gave me an awful pressure headache when I did.

And yes people, I think that 3.8g dosage has to be a mistake. Like they got a decimal point wrong or something.
 
I'm somewhat surprised no one has mentioned injecting mephedrone yet.

I know that as you get lower and lower on the rungs of human existence people begin to use needles as one of their basic tools- like junkies will inject vitamin c or alcohol for the hell of it.

So I 'know' that people are shooting mephedrone. But we haven't heard about it on bluelight at all yet. If it works that way, I bet the negative effects will show up in that community first. But maybe you'd need to be a pathologist to see it @ this time, and then you might not know what you're looking for in the dead guy's blood?
 
^ There are a number of posts in various forums around BL from people who have injected mephedrone. Including a few from myself as I've done it a number of times. I find it to be unimpressive and kinda pointless IV'd. I've tried it at various doses from 75-150mg from a coupla different batches. Many folks insist the powdery stuff is inferior to the crystal type with the latter being supposedly stronger, cleaner feeling and with less nastiness. Must admit it felt that way to me, although neither are exactly great :\

For me, the rush is nothing special, the peak feels admittedly rather yummy for a short while, then you get the shitty side effects kicking so another shot to put them off, rinse, repeat, end up with no meph feeling strung out and shitty. Not that I make a habit of it cos I'm not a big fan of meph at all but am a rampant drugpig and had a brief dalliance.

No ongoing problems other than the freaky heart sensations which persisted for a few weeks after using around 10g in a month. Suspect anyone using it more heavily and for prolonged periods would do themselves a nasty or two cos it really didn't feel healthy. My drug use in general isn't healthy but meph feels like poison to me :|

Not used it since cos it's nasty, toxic crap. And even worse it's a pretty shitty high :D

PS: And yes, I was once one of those junkies that has often shot up vit C and alcohol for the hell of it for many years - needles are my friend down here on the lowest rung of existence :)
 
PS: And yes, I was once one of those junkies that has often shot up vit C and alcohol for the hell of it for many years - needles are my friend down here on the lowest rung of existence
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O dear me.

My heart valves have been replaced by Mephedrone deposits. Maybe they'll hold up a bit better than that weak fleshy tissue those humans call a heart. Pfft
 
shoolameet said:
Has anyone on SSRI's given this stuff a shot?

I.
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Yes my friend mephedrone quite often and he is on SSRI's when he came off them for a brief spell he did not notice any change in effects of mephedrone.
And they are definately SSRI's as snorting a line of 5htp nearly killed him.

On a side note on a 3 day binge i consumed over 12gs of mephedrone and after the panic attack filled comedown noticed no other side effects.

Infact cumalatively since early august i have conusmed above 55gs at a conservative estimate and have not noticed any change physically or psycologically. That said my tolerances for all drugs are very high and so much so for mephedrone that i need at least 500 mgs to get a good high for more than 10 minutes.
 
Eh, it's probably both an SSRI and a serotonin releaser.

Why anyone would snort 5HTP is beyond me.
 
I don't often go out on this, i find the short peak means afterwards i get very indecsive, and undoubtedly the idea i had previously is no longer interesting.
However, me and the missus find it rather fun partaking in some use together and spending the night in ;]]]

Worst side effects probably after the 3G-4 Night mini-binge without sleep and eating.. but mainly i think due to lack of sleep/nutrients, i kept getting rushes through my body that'd make me jump and i'd hear a loud beep in my ears, but only when i tried to lay down, and they would come about every 15-20 minutes, luckily in one of the gaps i managed to sleep... for about 16 hours.. then since then no problems :]

We don't use loads, that was the most i'd ever used and longest period of use for a session
Usually an all-nighter, me and the misssus, about a gram, some weed, lots of water/squash and a long lay-in in the morning, followed by a good dinner.
Problem solved :)

And yes, there are some possibly harmful side effects! As are there to every substance we partake in the use of! It's all about researching a good starter dose, halfing it, then building up if need be, just to check how your system agrees with it.
First time you got drunk, undoubtedly you didn't drink 2 70cl bottles of jack daniels and realise you were being sick all night and woke up with a horrible headache..
If you drink a bit, then find your comfort zone, you may still wake up with a horrible headache, but, it doesn't stop you doing it again does it? Sounds really silly that we do when you look at it like that eh?
Oh and no, 'but when you start drinking jack hurts your throat' or similair gripes as mephedrone hurts your nose first time you snort it... comparable to mdma, but almost more of a burn eh?
 
shoolameet said:
Has anyone on SSRI's given this stuff a shot?

I am not on SSRI's, but have been in the past and may possibly go back on them. I don't roll often, but I do like to once in a while and if I am being medicated the opportunity to roll will obviously be taken away. So I was wondering about any interactions between Meph and SSRI's. Is it safe to combine? Will the meph still have an effect? Thanks.
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My gf recently started taking 20mg Citalopram (SSRI) daily. She got diminished effects from MDMA pills as expected but Mephedrone seemed to work well for her on two occasions so far (possibly had a greater effect on her than on other people in our group who weren't on SSRIs).

That's not to say the combo is not harmful in some way, I have no idea.
 
nuke said:
Eh, it's probably both an SSRI and a serotonin releaser.
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Is this comment (that it's a serotonin releaser) based on SAR's, comments from people who experience full effects from mephedrone while on SSRI's, or something else?

This would mean that mephedrone is especially dangerous for people on SSRI's, and the binge pattern could easily lead to serotonin syndrome, correct? Any idea why there aren't more reports of this?
 
Most monoamine releasers rely on transport via the respective transporter. Block the transporter and you will fail to get 5HT release it seems -- which is why fluoxetine blocks MDMA induced serotonergic neurotoxicity. Things that cause indirect release like DXM or inhibit catabolism like MAO-A inhibitors are the things that are toxic in conjunction with SSRIs.

And I meant to say that mephedrone is probably a serotonin reuptake inhibitor, but it's not selective.
 
I am such an impatient person - I really want to see some tests ran on this stuff. We have all of these speculated ideas for why mephedrone could be a very risky endeavor (and a fair bit of anecdotal evidence to suggest the same thing) but no formal studies or anything.

I don't really know anything about what has to happen for researcher to want to invest their time into a certain chemical. Will they wait until the government steps in and schedules it before someone finally steps in and says "Hey look everybody mephedrone metabolizes into chemical X, a powerful neurotoxin that causes parkinson disease, AIDS, erectile dysfunction, and severe anal fissures approximately 7 years down the road."

I guess I'm asking if we are close to getting some research published on this or does it usually take a long time for this sort of thing to occur?
 
Usually a government has to take interest because widespread abuse is appearing and they want to schedule the drug, but you can't really schedule anything anywhere until you know for sure how dangerous it is and what the abuse potential is (unless you're Germany). The government will then fund a study to examine the toxicology.
 
Operation Atlas said:
I'm not trying to say that this stuff is great for you, I'm just trying to argue that you guys are way overestimating the dangers of this drug. By saying such outlandish things people aren't going to listen to you and are just going to do the drug anyhow. People need to be aware that there are levels of responsible usage and that there are levels of irresponsible usage, and I think we should be concentrating on keeping people from using irresponsibly, instead of keeping them from using at all. Applying shit sticks and whatnot just makes you sound like reefer madness fear mongers.
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in the interest of harm reduction, i think the "dont bother with it, its too toxic and not worth it" stance is the best. once people know the dangers and risks associated, then they can make their own judgment call on whether or not to do it. there will always be risk-takers who will do dangerous things, like combine MDMA + reversible MAOI's (as i have done), or who wish to take a known amount of PMA just to see what its like (as i want to do), but such people typically dont until they know all the possible risks and dangers.

and the truth is, with how i've heard of people binging on mephedrone and how it apparently makes you fiend like you've been smoking crack, i'm all for the fear mongering, because its based on truth, and it will probably save more lives and bodies, which will keep governments from taking notice of this and all the other stuff that's now available.
 
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