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Insufflation Pain

Alright, so 20mg of 2C-B + HCl will have MORE acid than 20mg 2C-B + HBr, but as I said before in equimolar ammounts there is the same ammount. I think it's just a misunderstanding in what everyone is talking about. Let's try and get this back on topic.

So, the current theories for the pain are:
1) H+ ions as the substances dissociate
2) Dehydration due to diffusion of water out of nasal membranes(?)
(I'm assuming we've ruled out physical irritation since the pain isn't immediate)

Mixing with baking soda sounds like an easy way to test the former theory. If there's no burning then we not only know what causes it, but how to fix it. If there is still burning, then we've most likely ruled it out. Without doing the math I'd say that you probably need a lot less baking soda than 2C-x since the majority of the mass isn't from the HCl.
So, anyone up for trying this and reporting back?
 
totallynotme said:
So, the current theories for the pain are:
1) H+ ions as the substances dissociate
2) Dehydration due to diffusion of water out of nasal membranes(?)
(I'm assuming we've ruled out physical irritation since the pain isn't immediate)
Click to expand...
And there's kobilica's suggestion that the pain could be due to the chemical acting on nociceptors (pain receptors) in much the way it acts on neurons in the visual cortex and elsewhere, inducing a sort of nociceptive psychedelia. I've no idea if this is plausible; it would be the most reassuring explanation, as it would suggest that the increased pain in certain chemicals does not reflect any greater likelihood of damage.

A quick search brings up this paper which (from a glance at the title and abstract) seems to show that nociceptive processing is affected by activity at serotonin receptors, albeit the 5HT3 subtype. And the article referred to in this post shows that at least one psychedelic that affects 5HT3.
 
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Dear 2C-X rhinonauts,

Is the pain anything like the unfuckingbelievable burn that comes from snorting diphenhydramine?

Do the 2Cs have any action at the H1 receptor?

I'm a 2C virgin.

Edit: 2,5-dimethoxy-4-iodoamphetamine potentiates the capsaicin response at TRPV1 receptors.

Long-ass URL

http://jp.physoc.org/content/576/3/809.full.pdf

Seeing as these receptors (Ca ion channels) are activated not only by capsaicin but also by acidic conditions, this could be the culprit.
 
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I've never actually insufflated anything (just curious why it hurts) so I couldn't comment on the pain.

Anyways, nice find seep. I can't find anything on 5-HT3 activity for 2C-x chems, but it's certainly possible. The Capsaicin receptors are probably responsible for the pain associated with low pH conditions, though it's still possible it's from dehydration. If it's low pH a little baking soda would fix it, right?
If it's dehydration though, is it possible to fix?
 
Or saline with NaHCO3 buffer.

250px-Nasal_irrigation.jpg

SiNexus
 
Ok, here's a couple of thoughts
If 2C-X's act on nociceptors I'm sure the effect would be the same no matter the salt/counterion.
I don't believe the acid-theory since there are many monoamine salts which doesn't burn and the argument of HBr being a stronger acid than HCl is invalid in aqueous solution where no acid can be stronger that H3O+. In any case the amine will still be protonated at physiological pH and not 'lose' the acid.
I'm inclined to believe Vecktors theory about solubility in the order HOAc > HBr > HCl, but I concede that other amine salts may be local anaesthetics and mask the effect.
 
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