5,7 Dihydroxytryptamine

[tony serro]

The only research I could find on this chemical says its a potent neurotoxin used to kill 5-HT neurons in rats. Does anyone know why a basic tryptamine like this one would have such effects?

 

[vecktor]

The only research I could find on this chemical says its a potent neurotoxin used to kill 5-HT neurons in rats. Does anyone know why a basic tryptamine like this one would have such effects?

I believe it oxidises to a quinone type compound which makes free large amounts of radicals.

 

[nuke]

The big early review papers are as follows:

Degenerative effects of various neurotoxic indoleamines on central monoamine neurons.
Nobin A, Björklund A.
Ann N Y Acad Sci. 1978 Jun 12;305:305-27. Review. No abstract available.
PMID: 360938

Some behavioral effects of serotonin depletion depend on method: a comparison of 5,7-dihydroxytryptamine, p-chlorophenylalanine, p-choloroamphetamine, and electrolytic raphe lesions.
Lorens SA.
Ann N Y Acad Sci. 1978 Jun 12;305:532-55. Review. No abstract available.
PMID: 152081

Enzyme changes as an index of neurotoxin specificity.
Lovenberg W, Bruckwick E.
Ann N Y Acad Sci. 1978 Jun 12;305:182-9. Review. No abstract available.
PMID: 30374

Tryptophan hydroxylase of the central nervous system: effect of intraventricular 5,6- and 5,7-dihydroxytryptamine.
Lovenberg W, Victor SJ.
Adv Biochem Psychopharmacol. 1974;10:93-101. Review. No abstract available.
PMID: 4603031

There's another 1400 or so papers listed on pubmed, too...

 

[tony serro]

Yea i thought it would have something to do with free radicals thanks a lot, i had found the compound on a legit chemical supply site selling tryptamines sadly the only ones they sold were either neurotoxic or inactive.

 

[hugo24]

Its the indole cousin of the neurotoxin 6-HO-Dopamin (which itself is quite close to the 2,5-Dimethoxylated psychedelics).Following the same logic, 5,7-Dimethoxi-N,N-dialkyltryptamin should be an active psychedelic.Huh isn't that the title of an old "quite heated" thread,the 7-thiosubstituted Tryptamines being the sister to 2C-T's?

 

[Hammilton]

Well, I don't think it's quite the same logic. Tryptamines don't need any methoxy groups to be active psychedelics. They generally make them shittier psychedelics.

We're talking about different receptors. The ability of 5,7-dihydroxytryptamine to have effects similar to 6-OH-Dopamine is irrelevant to psychedelic effects, because the neurotoxic effects aren't related to 5HT2a receptors.