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Bupropion as phenylethylamine

panic_the_digital

panic_the_digital

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Feb 28, 2006
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In my pharmacy studies, I've seen bupropion described as a PEA. It's structure seems a bit different from the PIHKALs, but I was wondering if myabe there is potential to use this as a substrate for something more fun. Hope this isn't stupid and/or against forum guidelines.
 
I always thought it was a cathinone type molecule, making it similar to phenethylamine by the relation between PEA and amphetamine. Honestly I have no idea if it would be a good starting point to get to anything and I don't think it would be but maybe one of the more educated members on this forum can provide you with a better answer.
 
I wonder if both enantiomers are bioactive.

I wonder if a 3,4-dichlorophenyl variant would be of value.

Function of the tertutylamino cluster?
 
seusemgoose said:
I always thought it was a cathinone type molecule, making it similar to phenethylamine by the relation between PEA and amphetamine.
Click to expand...

it is indeed a cathinone.

cathinones, as well as amphetamines, could be considered phenylethylamines. amphetamine is phenylethylamine with an additional methyl (one carbon and three hydrogen molecules) group on the alpha carbon (the one adjacent to the amine). In fact, amphetamine is a conjunction of alpha-methyl-phenylethylamine. cathinone is amphetamine with an additional ketone (double bonded oxygen molecule) on the beta carbon (the one adjacent to the phenyl ring).

i suppose they technically aren't phenylethylamines as they no longer have an ethylamine group, but they can be seen as based upon the PEA structure.
 
seep said:
I wonder if both enantiomers are bioactive.

I wonder if a 3,4-dichlorophenyl variant would be of value.

Function of the tertutylamino cluster?
Click to expand...

The function of the tert-Butyl protecting group on the amine is to avoid being metabolized by MAO. It may also prevent VMAT2 and SERT uptake. If it were removed you'd be left with a rather nasty monoamine releaser, probably neurotoxic as the molecule would have an appreciable affinity for the release of DA/NE/5HT. Same goes for the 3,4-Dichloro.
 
it's not an analogue because any approved drug is outside of the analogue act's bounds: the gov' has had the option to schedule it when they approve it.

Even drugs for which a valid New Drug Application is submitted are outside the analogue act.
 
dont fuck with bupropion.....it can cause some extremely horrifying and realistic hallucinations, and yes, i've tried this at high dosess and its no fun.... no euphoria... nothing just suffering and bugs
 
A long time ago, someone had a webpage where he published (independent?) research about how bupropion is a cathinone and I think he compared receptor affinities, etc. I cannot find this page anymore.

For the record, Venlafaxine is also in a way a phenethylamine, but a heavily-substituted one.
 
i was in rehab with a kid who got sent there for trying to trip on a dozen Wellbutrin pills.


needless to say, he ended up in ICU suffering hallucinations and repeated seizures... fucking idiot
 
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