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Who has heard of phenyltropanes?

negrogesic said:
What makes these compounds promising? Radiolabelled version for mapping the DAT? ADHD meds?
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If we can find a cocaine analogue that works as well but upregulates rather than downregulates dopamine precursors that work as monoamine anti-depressant drugs do; then we have a way to counteract the long term CNS damage causing long term depression from cocaine use; in a way slightly analogous to how Suboxone helps upregulate mu-receptor activity by being a mixed antagonist/agonist: seeing how cocaine being a DARI works by Reuptake Inhibition, a simple process of reversing agonism and making an antagonist simply doesn't work for this process due to the very fact cocaine does not work by agonism of any sort (AFAIK).

Otherwise it is promising for how a single chemical can fill so many disparate receptor functions; to see medical molecular science better understand the basic tenets of a universal receptor activation mechanism to the various and far-removed (seemingly) in function receptors in the brain. Having them all fit one general universal profile seems to be promising for the furthering of science discovery in this channel of learning about the human brain and what kicks consciously noticeable affects into effect.... I before thought just the arylcyclohexylamine class of drugs had this skeletal structure promise, well if we can get a phenyltropane (or maybe a piperidine) to get NMDA antagonism in the mix it's ahead of the arylcyclohexylamine class for fitting the universal molecule effect ability of reinforcing all (generally considered) euphoriant type receptors. (That, and GABAergic possibly missing as well in that mix.)
 
nagelfar said:
if we can find a cocaine analogue that works as well but upregulates rather than downregulates dopamine precursors that work as monoamine anti-depressant drugs do; then we have a way to counteract the long term cns damage causing long term depression from cocaine use; in a way slightly analogous to how suboxone helps upregulate mu-receptor activity by being a mixed antagonist/agonist: Seeing how cocaine being a dari works by reuptake inhibition, a simple process of reversing agonism and making an antagonist simply doesn't work for this process due to the very fact cocaine does not work by agonism of any sort (afaik).

Otherwise it is promising for how a single chemical can fill so many disparate receptor functions; to see medical molecular science better understand the basic tenets of a universal receptor activation mechanism to the various and far-removed (seemingly) in function receptors in the brain. Having them all fit one general universal profile seems to be promising for the furthering of science discovery in this channel of learning about the human brain and what kicks consciously noticeable affects into effect.... I before thought just the arylcyclohexylamine class of drugs had this skeletal structure promise, well if we can get a phenyltropane (or maybe a piperidine) to get nmda antagonism in the mix it's ahead of the arylcyclohexylamine class for fitting the universal molecule effect ability of reinforcing all (generally considered) euphoriant type receptors. (that, and gabaergic possibly missing as well in that mix.)
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yum!
 
Not surprising that RTI-371 has cannabinoid activity, it's not really far removed from JWH-307.

Gives more evidence that the pentagonal ring in these can be just about anything.
 
Hammilton said:
Not surprising that RTI-371 has cannabinoid activity, it's not really far removed from JWH-307.

Gives more evidence that the pentagonal ring in these can be just about anything.
Click to expand...

Yes indeed.

Would any know what the most approximate / intermediate general base structure between phenyltropanes & arylcyclohexylamines would be? I am interested in knowing of any structure that someone could argue being an intermediate of those two types, just because of how universally they seem to be able to reach out to the main kinds of site activations that form substances for nearly all manner of recreational use/abuse. Any structure that could be argued as an approximate "middle road" of these two generalities (phenyltropane & arylcyclohexylamine)?
 
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