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The Large and Nifty Not-quite-advanced Drug Chemistry, Pharmacology and More Thread

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bean93 said:
I'm kind of new to Bluelight so hello every one! Wasn't sure whether to post in here but here it goes;
Could you theoretically use methionine in the methylation process to change phenethylamine to methylphenethylamine (which i believe to be amphetamine?) or would you need another reagent such as iodomethyl, and also how would one go about doing this?
I've been doing a lot of research on the internet about it and can't really find much about it other than a mention in PIHKAL, it just seems strange no-one has experimented with this.
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the short answer is no. Methylating phenethylamine gives N-methyl phenethylamine, amphetamine is alpha methyl phenethylamine a completely different creature.
there is a longer answer but there is a no synthesis discussion policy on BL.
 
This sounds like a round-about synth question. I'll send this to Advanced DD... if they allow it you'll get better responses there as those guys are really on the ball with this kinda stuff
 
You can simply purchase 99% acetone. It's pretty hygroscopic so it's generally hard to get it above 99.5%.
 
If one were to inhibit her MAOB, would we expect the following analogy to hold in terms of effects:

amphetamine is to methamphetamine as phenethylamine is to n-methyl-phenethylamine?

And wouldn't a straight-forward methylating agent, as 'bean93' suggested, also yield n,n-di-methyl-phenethylamine, etc.?

ebola
 
oops I'm used to posting on another forum I'll be sure to read up on posting rules. Well thanks for the short answer pretty much all I needed. I take it N-methyl phenethylamine is unactive as theres not alot of material on it's research. Could anyone point me in the direction of a good biochem/pharmacology post they have read (Y)
 
After synthesis of JWH-018, what would a pure product look like? I've heard white is the purest, but a few vendors I've talked to have claimed to have the purest product around even if brown. For example, i just got this reply from a vendor: "Its not white. and white dose not mean pure.
things like that have been chemcialy made that way. to look clean and often result in a weaker product. which can be cut with anything under the sun without visualy knowing. lots of white bulking powers etc.
i got lab results that the jwh is 99.999 Assay even though its a brownish colour. "
 
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ZzZzZ said:
99.999 Assay even though its a brownish colour. "
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thats bullshit for a start. 10 ppm total impurities, dont make me laugh.

A general point practically no organic chemicals except for special purposes like electronics are that pure.
 
And no HPLC assay gives you 99.999% like results.But for sure,I can show you HPLC's showing a 100.000% pure Product ...

Altough you CAN color a product with ppm's of certain impurities.
 
Yeah, when you start going below 98.5% purity you start getting a little yellow. I had stuff that was 96% pure that was pure yellow.

The only brown brown stuff I've seen was later found to be between 75 and 78% pure. If you have brown stuff, it's probably between the 70s and 80s percent purity. I've never seen JWH-018 that was in the 80-90% purity, though I'm sure someone here has.
 
Though colour isn't necessarily always an indicator of piss-poor product... I had degraded 4-AcO-DET that went to a brown colour (assumably the n-acetylated version of 4-AcO-DET) but didn't encounter any major loss of the main product.
 
Right, absolutely, but in the case of JWH-018, pretty much all of the brown stuff around will be <90% pure. It's possible that it could be higher, but it's rather unlikely. The byproducts of 018 synth seem to be pretty strongly yellow. I don't know what the brown shit is.

I know someone somewhere had commented on this, after doing extraction on the brown shit that was being passed around, but I don't remember what he said it turned out to be.

And the vendor is partially right, it would be possible for someone to cut the product so that it turned out to be white, but you'd end up with severely degraded product, in a way that ought to be obvious.

the claims that it's being "chemically turned white" - well, that's sort of true, but it's just basic extraction. This is what the no sources! - nuke people were claiming when we were having our issues with them, and I believe that our issues cost them a lot of business, as they eventually changed labs and now have white product.

Most of these people are idiots and don't know better themselves. I think they're probably buying the nonsense that their chinese labs are telling them. It's obvious that these places have no problems faking the results.
 
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It has a mild affinity for the serotonin transporter. I don't believe it has any strong affinity for any of the serotonin receptors.
 
Allright thank you, one more question.

What 5HT receptors decrease response to MDMA when antagonised? And are there any 5HT receptor agonists that decrease response to MDMA?

Thank you.
 
Dexedrine into Freebase Dextroamphetamine

I'd like to start off by saying I read the rules and didn't think this question was against them, if so, I am sorry.


My question is, has anyone extracted the dextroamphetamine dextroamphetamine sulfate from Dexedrine tablets and then turned it into freebase dextroamphetamine? Does anyone happen to have a tek explaining the process? Any help would be greatly appreciated.
 
I think the problem is that amphetamine is supposedly an oily ammonia like liquid when freebase so it would take some careful process to get it out. If you're trying to smoke it, you can maybe get away with amphetamine carbonate or bicarbonate which should decompose under heat to CO2, H2O, and freebase amphetamine.
 
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