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Ketamine as SSRI?

Jamshyd

Jamshyd

Bluelight Crew
Joined
Aug 26, 2003
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Not on a train, sadly.
Recently it was pointed out that Ketamine may be a risk of Serotonin Syndrome.

Now, I don't fully buy this, because I know that all my friends and myself almost never take ecstast without taking regular bumps of K throughout.

Here is the actual study:

Ketamine inhibits serotonin uptake in vivo.

Martin LL, Bouchal RL, Smith DJ.

Anesthetic (120 and 160 mg/kg. i.p.) and subanesthetic (80 mg/kg) doses of ketamine HCl were found to prevent completely the depletion of whole brain serotonin (5-HT) by p-chloramphetamine (PCA). Furthermore, ketamine HCl (160 mg/kg) completely blocked the depletion of 5-HT by PCA in every individual brain region studied (Midbrain-thalamus, hypothalamus, striatum, hippocampus and cortex). Administration of ketamine alone had no effect on brain 5-HT levels. Nialamide (a monoamine oxidase (MAO) inhibitor) and fluoxetine (a selective 5-HT uptake inhibitor) also prevented the depletion of 5-HT by PCA. However, of these three agents, only nialamide prevented the depletion of 5-HT by reserpine. These results suggest that ketamine blocks PCA-induced 5-HT depletion by inhibiting 5-HT uptake and not by inhibiting MAO. Ketamine only weakly affected either [3H]5-HT or [3H]spiroperidol binding to 5-HT1 and 5-HT2 receptors respectively even at concentrations as high as 1 mM. These data support the contention that the primary direct effect of ketamine on serotonergic systems is the blockade of 5-HT uptake and that blockade of 5-HT uptake may mediate some of the behavioral effects of ketamine, such as analgesia.

http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=6460944&dopt=Abstract
Click to expand...

It does seem that Ketamine's SSRI action is rather context-bound (sorry to use literary terms in pharmacology :p). And if I dare say, the effect is a protective one? ;).
 
you ketamine lover, you!
I think I know you...and you don't know who I am....but if you are the same Jamshyd that once blogged about waking up to lawnmowers...and called me Loki....and once touched my breast....you should know who I am...

If you are extremely confused...well I only know one Jamshyd who would be a MOD on a drug forum and boasting about ketamine....if this is not you my loving friend in the west end of our city than I am sorry....I have you confused...but it would be way too much of a coincidence not to say anything....so....if this is you im speaking of...I LOVE YOU AND MISS YOU!
p.s. what are you doing on BlueLight???
( and im sure you're going to ask me the same thing)
 
interesting.. *bump*
What interaction will K have with Lexapro
 
i can't be sure... but i think i took some when on citalopram and i'm alive... but don't take my word for it at all... that might have been when i stopped taking it.

done it on dosulepin (a TCA) and i've been fine. did knock me out fairly well tho... and keepin your member full mast on ket is near impossible :D
 
monstanoodle said:
keepin your member full mast on ket is near impossible
Click to expand...


The thought of being familiar with a world containing the concept of a 'member' on ketamine, would equal a k experience with zero worth, IME.
 
SSRIs and MDMA don't cause serotonin syndrome. The SSRIs cancel the MDMA out.

If Ketamine is an SSRI, though, combining it with other SSRIs could easily be dangerous.
 
It seems that many people are missing the part of the research that suggests that whatever SSRI action that Ketamine has, is situational and indirect at best. It is definitely not SSRI in the typical sense.
 
fastandbulbous said:
SSRI effects (learning not to spiral down into a depressed mindset)
Click to expand...
this is interesting. could you develop on the psychological effects of SSRI (I am myself on citalopram, and like it)?
 
Look at the binding affinities for Prozac. The term "selective" was quasi-ironic from the get-go. It's only recently that highly selective agents have risen to the fore. Your larger point stands, though.

ebola
 
Well, we were leaving TCAs behind, which were even messier. Selective sounded good.

It's funny though, and I read this point in a book once, about how when TCAs were big, it was their broad action that was touted. then SSRIs came in, and their singular action was touted. Then the SNRIs came, and their dual action was the selling point. now the TRIs are in clinical trials and they'll be touted for their broad action again.

It's quite funny, actually.
 
I've noticed, and probaby most of you naughty ravers out there have too ;) , that doing k during/on the comdown is not only extremely pleasurable, but seems to leave me feeling better then a rolled out night without it.

Thanks for posting this Jammy! :D
 
It really adds an extra dimension to the MDMA. Make that 10 dimensions :D
 
El Cubano Poco said:
I've noticed, and probaby most of you naughty ravers out there have too ;) , that doing k during/on the comdown is not only extremely pleasurable, but seems to leave me feeling better then a rolled out night without it.

Thanks for posting this Jammy! :D
Click to expand...



Possibly due to the SSRI (yes I'll go back to using that! =D) activity at the end of the MDMA experience. The one time I took ketamine at the end of an MDMA experience, the depression that usually follows was much reduced, almost to the point of making me consider using MDMA again (I said almost!)
 
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