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How to diminish phenobarbital half-life

cilous

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Aug 5, 2009
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Hey everybody

Since I have benzo immunity and Zolpidem do shit for me I've been perscribed pheno for my severe insomnia.Well I've really dig it haha , but the half life freaked me out.Is there anyway you guys can figure out to decrease pheno half life ? 100hours is way too long.Thanks
 
I should warn you that this thread is in all likelihood going to be deleted or moved very shortly.

The first idea tha..... wait... actually, the first thing I want to say is stop bullshitting us. Even though for most people phenobarbital is complete shit and has almost zero recreational potential, I still have a number of reasons to believe that you are using it for recreation and for little else (not the least of which being that you said, "Well I've really dig it haha"). No one here cares a whit really what you use or why, generally speaking, but the advice you're going to receive changes depending what the purpose is of your use of phenobarbital. If you're just using to get high, my advice would be to stop this very instant and smack yourself for being such a dumbass until you learn not to develop an agonizing and even potentially lethal withdrawal syndrome for the use of something so shitty as phenobarbital (if smacking yourself with your hand is not suitably painful, you may substitute with a hammer or some other implement of carpentry or what have you.) If you're indeed taking it for insomnia, then I'd suggest either that you look harder for an alternative hypnotic drug, because you obviously haven't looked hard enough; that you take less of the phenobarbital (this is a good idea regardless); or that you take rifampicin since that is, according to Wikipedia at least, a CYP2C19 inducer and should speed up the metabolism of the drug some, although not necessarily appreciably.

I am not liable for any health problems that result from the long-term use of rifampicin - nor short-term for that matter.
 
sorry if it is in the wrong part of the forum.I'll delete it future.Benzos really don't work at me (neither then-long lasting or hypnotics.I tried valium xanax klonopins lexotan (lorazepam ) dormonid and rohypnol.Also tried zolpiden seroquel zyprexa I.M phenergan plus exercise acupunture no caffeine all the shit..So it is.I'm aware of the dangerous.But Since each time I skeep a night (some times even 48hr) I fry precious neurons that could have been spended having fun I'd really like to have some sleep.I'll try your sugestion thanks.The only thing that really put me out are opiates.
 
Well, I'd like to help you with your sleep because I can easily sympathize, but if you've really tried all that and nothing else has worked then... phenobarbital it is. Just in case, I'll give you a list of all soporific/hypnotic drugs/supplements available that I can think of off the top of my head (excepting benzodiazepines, barbiturates, quinazolinones, z-drugs, unattainable GABAergics (etomidate, propofol), and alcohol):

Carisoprodol
Meprobamate
Mirtazapine
Trazodone
Cyproheptadine and Amitriptyline and other classical tricyclic antidepressants
Paroxetine
Lamotrigine (Not really recommended)
Phenibut (Relatively short, but truly horrific withdrawal syndrome if used long enough.)
Baclofen (ditto)
Muscimol (Shoddy, ungainly efforts based on cursory research to promote the conversion of the ibotenic acid in Amanita Muscaria mushrooms into muscimol could lead to excitotoxicity which is something someone in your position really doesn't need. GABAergics don't really seem to work that well with you, anyways, but I thought I'd include for the sake of completeness.)
Diphenhydramine and dimenhydrinate (neither of these comes with any recommendation at all, but they will facilitate sleep, albeit non-recuperative, troubled sleep from hell)
Agomelatine
Tasimelteon
Ramelteon
Melatonin
Taurine
Magnesium (without calcium)
Pregabalin
Carbamazepine
Topiramate

Edit: Beta and alpha blockers are pretty soporific, although they won't necessarily (and probably won't) enhance sleep quality. These are not to be used with any other central nervous system depressant, by the way (for that matter don't mix them with anything, if you don't know what you're doing). Clonidine and guanfacine are better choices than selective(-ish) adrenergic receptor antagonists. I recall that when I first used clonidine it made me very sleepy.


I found after a good deal of experimentation that the combination of pregabalin and mirtazapine really knocks me out. Unfortunately, the combination has a very funky synergy and I always feel awful and depersonalized the day after using it. Mirtazapine in one study - although I do not know by whom it was funded - was said to "normalize sleep patterns" supposedly (semi-)permanently increasing length of time spent in deep stages of sleep when used over a period of a couple weeks in patients with insomnia. I don't have the study on hand and don't know where to find it at the moment. My current sleep regimen is 3 mg of melatonin (start with one; people typically find lower doses more effective than higher), taurine, magnesium, 150 mg of pregabalin and possibly a small amount of lorazepam. I don't feel that well-rested but at least I'm not going crazy from sleep deprivation.

Divalproex, I've read, decreases the activity of GABA transaminase, increasing levels of GABA. Pregabalin on the other hand - and this is not particularly credible information - upregulates translation of glutamate decarboxylase, again increasing GABA levels. I don't really recommend that you try combining them (I don't know of any specific negative interactions but my intuition tells me that there could be a great deal of them). I don't really even recommend that you take divalproex alone, but it's something to try if you run out of options, I guess, or something...

And be on the look-out for Almorexant; it could take a while, but there's little doubt that that will prove efficacious in treating your insomnia.

By the bye, if you're worried about "frying neurons" phenobarbital is not really for you. I mean, it's better that insomnia, but GABAergics antagonize long-term potentiation, the foundation of memory and learning, and that's just as good (bad) as "frying neurons". They also suppress transcription/translation of growth factors since they depress brain activity. Increased brain activity is associated with the opposite, increased expression of growth factors such as BDNF. (Of course, if the brain is too active, you have excitotoxicity.)
 
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I should warn you that this thread is in all likelihood going to be deleted or moved very shortly.

The first idea tha..... wait... actually, the first thing I want to say is stop bullshitting us. Even though for most people phenobarbital is complete shit and has almost zero recreational potential, I still have a number of reasons to believe that you are using it for recreation and for little else (not the least of which being that you said, "Well I've really dig it haha"). No one here cares a whit really what you use or why, generally speaking, but the advice you're going to receive changes depending what the purpose is of your use of phenobarbital.

I'm not much of a bluelighter but I disagree with you, I found phenobarbital to be quite effective. Interestingly, I found that Corvalol pills suck and had very little effect, however the tincture with the powerful smell (real popular in Russia) is extremely effective. Just a tiny bit of it induced a very sleepy feeling even to the next day I was drowsy (felt kind of good). Only bad thing I noticed is that after about a week of doing it I had to go on a trip, and I remember trying to fall asleep in a hotel was completely irritating and I had a very bad headache. Xanax I've also tried numerous times and it's very different, I wouldn't even say it is more recreational. It makes you fall asleep but it lacks that very foggy almost nod like quality that makes phenobarbital fun.

The OP did have some sense, I've found many times that I was extremely drowsy the earlier part of the next day after using corvalol tincture the day before I would be very drowsy, not unpleasurable but I remember being completely drowsy/foggy it feels really great trust me although I would see why you would want the effect to go away if you have something important. I think if you keep using phenobarbital, your body will adjust so the effects will go away quicker by the next morning.
 
Diazepam decreases blood levels of phenobarb, and vice-versa.

Are you joking? It's a pretty irresponsible joke if so. That combination is the most dangerous I have ever taken. While technically your statement might be correct, in practice doubling up on both of those is stupid.

Effects, from personal experience, may include forgetting you have taken either, and taking more. Waking up places with no recollection of the previous 24 hours etc. etc. Bad, bad idea - whatever about taking phenobarbital on it's own.
 
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