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Transdermal psychs

dorothyperkins

dorothyperkins

Bluelighter
Joined
Oct 18, 2007
Messages
426
Anyone tried?

I spread 200 ug of 25B-NBOMe (2x100ug, about 45 min apart) on my forearm and all I got was an itchy arm, and slight rash :D

Not really sure how else to dose the stuff, without injecting.
 
Apparently inactive orally, but active sublingually. I just don't fancy weighing out 0.5mg, even with a 0.1mg scale, and liquid measurement probably means half an hour with a mouth full of saliva...
 
very interesting chemical, i suppose you could put some on a blotter & hold that under your tongue... also from what i've read i didn't think it was active below 400-500mcg, so you might have not used enough. Haven't heard anything about rectal administration.
 
I recall Nick Sand saying he made a DMSO solution with what would be a large amount of LSD orally and rubbed it all over himself and it did not intoxicate him in the least. So, er, maybe if someone has a good education in polymers and could make something a la a nicotine patch, it may work, but DMSO may not be the best solution here.
 
^ think i recall reading that as well. I'm not sure of the methods used for things like fentanyl, but if i remember correctly some of the isomers of fentanyl have a dose range similar to 25B-NBOMe, however I'm unaware if they've ever been put into a transdermal system. Also, I think heat can drastically effect the rate of absorption with most transdermal systems.... just stuff to think about
 
DMSO dissolves polymers, peptides, & other things, maybe it didn't go through the skin membrane because the DMSO dissolved the stuff he was trying to get across before it could transfer?
Does anyone know exactly how DMSO works as a drug carrier? And if it works as a drug carrier for morphine, which it is supposed to, then how does it get the morphine across the skin membrane before it dissolves it?
 
DMSO will pull most chemicals, including steroids into the blood stream, you have to make sure the chemical is dissolved really well in excess liquid. I don't think there is any research on this kind of stuff specifically directed at psyches

from memory DMT is not active if used in a transdermal application
 
jari said:
Does anyone know exactly how DMSO works as a drug carrier?
Click to expand...
I tried to figure this out years ago and ended up frustrated. I just tried again and found this.

http://cat.inist.fr/?aModele=afficheN&cpsidt=19035759

Despite the vast number of experimental studies, the molecular basis of its action on lipid membranes is still obscure. A recent simulation study employing coarse-grained models has suggested that DMSO induces pores in the membrane (Notman, R.; Noro, M.; O'Malley, B.; Anwar, J. J. Am. Chem. Soc. 2006, 128, 13982-13983). We report here the molecular mechanism for DMSO's interaction with phospholipid membranes ascertained from atomic-scale molecular dynamics simulations. DMSO is observed to exhibit three distinct modes of action, each over a different concentration range. At low concentrations, DMSO induces membrane thinning and increases fluidity of the membrane's hydrophobic core. At higher concentrations, DMSO induces transient water pores into the membrane. At still higher concentrations, individual lipid molecules are desorbed from the membrane followed by disintegration of the bilayer structure. The study provides further evidence that a key aspect of DMSO's mechanism of action is pore formation, which explains the significant enhancement in permeability of membranes to hydrophilic molecules by DMSO as well as DMSO's cryoprotectant activity.
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Also, dissolving drugs in DMSO doesn't typically stop them from working. (I've read the most effective concentrations are in the 70 - 90 percent area.) If I was going to use DMSO I'd skip transdermal and use it to speed and enhance sublingual or rectal absorption (may not be a comfortable experience though).
 
jamaica0535 said:
plug it?
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Maybe 8o I know, it's probably not that bad... :\

I heard the Nick Sand LSD story too, thought this was different enough that it would maybe work. Still tempted to try freebased 2CB, though I doubt it would make a difference weather it's a salt or not. The pic of a fentanyl patch on wiki (http://en.wikipedia.org/wiki/File:Fentanyl_Transdermal_System_50_mcg_Patch.jpg) says it contains 5 mg fentanyl, I guess this doesn't necessarily mean it's not a salt though.

psood0nym said:
Also, dissolving drugs in DMSO doesn't typically stop them from working.
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How would it stop them from working!? And it kinda burns if you put it in your mouth, similar to alcohol IIRC, which means a mouthful of saliva within seconds!

Anymajordude, blotter's not a bad idea. I'd expect an effect from 200ug, 300ug of DOB (orally) had a definite effect.
 
^That was a response to jari, the person whose post I quoted part of above, who asked: "maybe it didn't go through the skin membrane because the DMSO dissolved the stuff he was trying to get across before it could transfer?" I think jari thought the DMSO reacted with the drug and chemically changed it.

Because the amount of drug you're trying to absorb is so little, very little DMSO would be needed. If I was going to try it sublingually and was worried about saliva, I'd pull the back out of an insulin syringe, drop the 200ug to the bottom of the syringe dry, put the plunger in (lightly squishing the crystals between the plunger and needle, then draw in a small amount of DMSO solution (like 5 units). Dripping such a minuscule amount between your lower lip and gums would isolate the solution from saliva and swallowing. That or man up and just squirt it up your butt already!
 
psood0nym said:
^That was a response to jari, the person whose post I quoted part of above, who asked: "maybe it didn't go through the skin membrane because the DMSO dissolved the stuff he was trying to get across before it could transfer?" I think jari thought the DMSO reacted with the drug and chemically changed it.

Because the amount of drug you're trying to absorb is so little, very little DMSO would be needed. If I was going to try it sublingually and was worried about saliva, I'd pull the back out of an insulin syringe, drop the 200ug to the bottom of the syringe dry, put the plunger in (lightly squishing the crystals between the plunger and needle, then draw in a small amount of DMSO solution (like 5 units). Dripping such a minuscule amount between your lower lip and gums would isolate the solution from saliva and swallowing. That or man up and just squirt it up your butt already!
Click to expand...

Thanks for your answer dude :) You have shed some light on the subject but I am still confused. Since DMSO is supposed to penetrate the skin's membranes and be capable of rapidly taking other drugs along with it, I thought it would work as a transdermal method and eliminate the need for such ROA as needles, plugging, etc.
That was the main point of the drug, to work as a different ROA, but since someone said that it didn't work (in one situation) I thought maybe it was because DMSO dissolves peptides,etc.& therefore interfered with the drug. It was acid, and since DMSO is a solvent, it could have altered the chemical makeup of the acid. (?)

Since you have pointed out that the DMSO would only dissolve the drug at a very high DMSO to substance (drug) ratio, then I would think it would work as it's supposed to, and carry the drug with it across the skin membrane, where it absorbs very quickly (and I would think eliminating the need for other ROA).
I am wondering if morphine can be carried transdermally with DMSO if I was to put it on the skin over the area that hurts (my leg).
I am having trouble getting any data on this, DMSO is used for all kinds of things all over the world, but the fucked up greedy ass USA-FDA-Pharma companies haven't found a way to make billions, so they shelved it.
Does anyone have any experience with this, or know anyone who has? Much Thanks :)
 
I have some DMSO that is 70% DMSO and 30% aloe vera, and I have been applying it directly on my skin over the painful area, and it has gotten WORSE! Maybe it is because the quote above about DMSO at low concentrations, or maybe because it is supposed to be great for arthritis, and I have neuropathy. I have ordered some 90% DMSO and still waiting for it. Naturally I am curious whether it can be used transdermally with other substances.
 
jari said:
It was acid, and since DMSO is a solvent, it could have altered the chemical makeup of the acid. (?)
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Nope, DMSO is fairly inert, and not likely to react with (alter chemically) any drug I can think of.

Since you have pointed out that the DMSO would only dissolve the drug at a very high DMSO to substance (drug) ratio,
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Most drugs are probably very soluble in DMSO, so you don't need very high ratios of DMSO to drug, relatively speaking. I'm not sure what you mean by the next bit though.

I have some DMSO that is 70% DMSO and 30% aloe vera,
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Really? Is that safe!? Crude plant extracts aren't something I'd want to be putting directly in my bloodstream!

I'm sure it works for some things, at least, somebody posted something about people using it to take steroids without injecting, so I was thinking to ask in OD instead. Think I'll just take psood0nyms advice and squirt it up my ass though. =D
 
dorothyperkins said:
Nope, DMSO is fairly inert, and not likely to react with (alter chemically) any drug I can think of.



Most drugs are probably very soluble in DMSO, so you don't need very high ratios of DMSO to drug, relatively speaking. I'm not sure what you mean by the next bit though.



Really? Is that safe!? Crude plant extracts aren't something I'd want to be putting directly in my bloodstream!

I'm sure it works for some things, at least, somebody posted something about people using it to take steroids without injecting, so I was thinking to ask in OD instead. Think I'll just take psood0nyms advice and squirt it up my ass though. =D
Click to expand...

The aloe vera preparation.... I don't think that the 70% DMSO is "strong" enough to carry anything into the bloodstream-including the aloe vera.
 
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