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Who has heard of phenyltropanes?

H

Horrux

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Aug 26, 2009
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Cocaine analogues, sometimes 5x more potent, equally short-lasting...

Maybe one of them is a lot less addictive?

They don't seem to be exactly illegal either...
 
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Google 3-pseudotropyl-4-fluorobenzoate and you should be able to find all the info you need from there. Pubmed has a lot of info on them as well...
 
Based on my limited understanding of the science, a chemical analogue (so logically... a similar mechanism of action) can't really be more potent but at the same time less addicting. They're both inextricably tied to the effects on the user.

Although, I wouldn't really consider *real* cocaine all that addicting anyways
 
Based on my limited understanding of the science, a chemical analogue (so logically... a similar mechanism of action) can't really be more potent but at the same time less addicting. They're both inextricably tied to the effects on the user.
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yeah, extremely limited I guess. Potency and efficacy are not the same thing. Buprenorphine may be much more potent than morphine (and also a close analogue) but it has much lower efficacy (to the point of being a partial agonist) and is much less addicting.
 
Hammilton said:
yeah, extremely limited I guess. Potency and efficacy are not the same thing. Buprenorphine may be much more potent than morphine (and also a close analogue) but it has much lower efficacy (to the point of being a partial agonist) and is much less addicting.
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True, and I'm fully aware of that... I was just addressing it as if the OP assumed "potency" was something recreationally relevant.
 
Oh yes, I know how it looks like. Thank you anyways for your effort!

There's hardly any data to be found, not even speaking of bioassays. Would be an incredibly interesting read, in particular considering the ease of preparation.

- Murphy
 
An update:
Oh look, I found at least some hints in a NIDA Research Monography. See vol. 81 from 1988. around page 520.
NIH 10479: ortho-MeO
NIH 10480: ortho-OH
NIH 10481: no substituents at the Ph

Maybe this helps with further searching.

- Murphy
 
This thread (and this post in particular), speak of a phenyltropane that is an "amphetaminergic DA releaser" in addition to being a DA reuptake inhibitor. (It is Exo-2-phenyl-7-azabicyclo[2.2.1]heptane).... interesting if opioid activity, the potent binding reuptake inhibitor that is way moreso than normal amphetamines innate to tropane stimulants generally, and the DA releasing activity of amphetamine like substances could all be fit on one molecule. I suppose if any molecule could do it, that would be a phenyltropane.

RTI-371 (another phenyltropane) also appears to be a cannabinoid in addition to a DARI, so we have THC/Marijuana-like activity too. WF-11 (yet another phenyltropane) apparently down-regulates the dopamine precursor rather than up-regulates it as cocaine does (so that depression grows with a history consistent use, more cocaine is needed to achieve effects, etc; apparently with WF-11 the opposite is the case). etc. etc. A very interesting and in my opinion promising series/class of chemicals.
 
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Forgive me if this is a sophomoric question, but how do you fuse cumene's isopropyl group to the 2 and 5 positions of pyrrolidine?
 
negrogesic said:
What makes these compounds promising? Radiolabelled version for mapping the DAT? ADHD meds?
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there are a handful of stupidly addictive euphoric hedonistic compounds in this group.

Neurosearch are running with a few phenyltropanes for weight loss, ADHD depression and similar.
 
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