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  • BDD Moderators: Keif’ Richards

Taking soma rectally? Along with rectal oxycodone?

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O

oxyhydro

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Hi guys,

I just got a new script for Roxi 30's and recently discovered that the Soma I've had sitting in my medicine cabinet for a year is great for potentiaiting opiates! I had gotten the Soma because I was grinding my teeth at night but only had taken a few pills so I still have 27 left, they are 350mg.

The posts I've been reading about Soma all say that a relativity low oral dose of Soma should be taken about the same time as you r dose of opiates. I was wondering that since I usually take my oxycodone rectally, if I could crush a Soma up and shoot it all at once (up my butt). I think this should work because most drugs that are orally bio available have an even better bio-availability in the rectum (oxycodone for example) but I would like some feedback from someone who has tried this or knows of someone who has tried this.

Also should I lower my usual dose of Oxy? I Usually take 1 and a half roxi's so 45mg oxy total, was thinking of taking 2 soma (700mg) and 1 roxi (30mg) for the first time.
 
Soma is a prodrug IIRC, so that means that it needs to be converted into something else in your liver (meprobamate, maybe?) in order to be effective...so plugging it wouldn't work. Your calculations for the roxi sound about correct, but you'd have to take the soma orally.
 
wiggi said:
^ Agreed. OP, post a link showing where the BA of oxycodone is higher when used rectally instead of orally.
Click to expand...

Here is a link: http://www.opioids.com/opiates/index.html look under sub topic B titled "Tips for ingestion", they claim the bioavailbility is at least 10% higher. Also bookmark the page because it has a ton of useful information.

I've done some more research and found that many other sites that seem more legit than the link I posted claim the bioavailability to be the same as oral, however rectally is still superior IMO because the Oxycodone hits you faster when you take it rectally, and you can have a full stomach. It also is good if oxycodone upsets your stomach when taken orally because that wont happen if it doesn't go into your stomach.

If anyone can find another site that claims the rectal bioavailbility of oxycodone is higher than the oral, please post the link!
 
If your plugging the oxy and eating the soma, I'd start with 30mg oxy and 350mg soma and eat/plug more as needed. Especially since your not experienced with plugging oxy - may hit you harder than you expect. Mixing soma with the oxy also makes the experience way more sedating and lethargic.
 
Sorry to resurrect a dead thread, but this is what comes up if you search for plugging Soma. I don't have any Soma to try this with, but I suspect that you can plug it just as you can plug codeine -- that is, yes, it needs to be metabolized by the liver, but once it enters the bloodstream it'll get to the liver regardless. In my limited understanding carisoprodol and codeine are very much alike in this respect, and codeine definitely works. It definitely seems like a worthy experiment next time I get my hands on some Soma; even if it doesn't increase bioavailability to take it rectally, you at least get past the need for an empty stomach, and hopefully the highly irregular rate of absorption and onset that many users experience.
 
^ this is my understanding as well. It's mentioned in forums here and there, actually on BL in a few places and it does work with codeine, tramadol, maybe other prodrugs (I can't speak to those as I don't have experience with plugging any other prodrugs)

I, too, apologize for reviving this dormant thread but, as said above this is the only thread that comes up in a search so no use starting a new one me thinks..
 
okay - i'd LOVE a definitive answer to the plug/swallow Soma question. i've read reasonable arguments on both ends (no pun intended! lol!) -- my personal experience, shockingly, is that orally is more effective, though this doesn't make sense to me. the argument that it needs to pass through the liver to turn into meprobamate, and that plugging will still require it to do so, makes sense, but i'm wondering... is there something like "first pass metabolism" that, maybe plugging bypasses, and could that explain why orally works better?? this question is baffling me!! help!!

;^)
 
Everything absorbed by your stomach and most of your GI tract (excluding your rectum) is transported via your bloodstream directly to the liver. You are plumbed so the blood supply from your GI tract heads to the liver via the portal vein and passes through the liver before heading to your heart and rejoining the rest of your circulation. Usually blood leaving organs doesn't travel via the liver in this way - it just returns directly to the heart.

This special plumbing (known as the portal system) ensures that any nutrients or drugs head to the liver first where they can be metabolised, before entering your general circulation. This is called "first-pass metabolism".

Once anything reaches your heart it is pumped around the body and dispersed into the general circulation. It will encounter the liver at some point, but in a much less timely fashion.

The blood supply from your rectum does not behave in the way the blood supply from the rest of your GI tract does - it just heads directly to the heart and ignores the liver. In time, anything absorbed from the rectum will reach your liver - in the same way that in the above example, the nutrients/drugs will re-encounter your liver at some point - but they do not have the direct, immediate route there, therefore they are not said to undergo "first pass metabolism".

So - Soma taken rectally will eventually encounter your liver, but it will take a lot longer than if you ate it and it had a direct route there.

Does that make sense? :)
 
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^^^Yes it does :)

I don't see the point of plugging oxy; it has a great or BA, and rectal is no higher. Actually, I've heard many people say that oxycodone is one of the least effective drugs via the rectal route, though I don't know of any facts that support this, and the BA for both is listed 60-87%. I am sure some people with a haphazard digestive system might benefit from rectal, but otherwise, there is no reason for it.

As for as Soma is concerned, Effie is right; it will encounter the liver EVENTUALLY, but it will take a while, and only a little will be metabolized at a time.Ultimately, a much smaller portion of the soma will be converted into meprobromate(?) giving substantially less effect. BUT what no one here has mentioned is that Soma isn't full a pro-drug because it DOES HAVE full effects on it's own. In fact, the dosing for Soma and it's parent drug is exactly the same; this is because it's metabolite is only responsible for half of it's effects; the other half is the effects of Carisoprodol itself. Thus, eliminating first pass metabolism will most likely make the effects less intense, but the main difference is that carisprodol itself will me active in larger doses. This means that the drug might only be slightly less potent overall, it's just that the effects will be of carisoprodol itself, which will almost completely change the effects.

That said, meprobromate is pretty much 100% responsible for the recreational effects of Soma, however I suspect both drugs contribute to opoid potentiation. Overall, it is up to you to try BOTH methods at least twice to see what works best for you. However, keep in mind that Soma has a very high oral BA, and so, like oxycodone, there is no way rectal BA is any higher than oral, and most likely it is less effective, maybe even substantially less effective. So I would just stick to oral, but, in all fairness, the only times I have tried rectal the effects we're either non-existent(oxymorphone for example, didn't even reieve DT's, and it's almost 20x the potency of oxy!) or just less effective than any comparable route. So again, if you like rectal administration, AND you are just looking to potentiate your oxy dose, it is up to you to try both ways and see what works. But if you want any ENJOYABLE effects from the Soma itself, you must go oral.

(forgive the long post, but I think this covers all the bases with Soma metabolism and the respective effects of Carisoprodol/meprobromate for any future readers)
 
^ agree with all this :)

I think everything has been covered now, and as this was an old thread resurrected to have one point clarified, I'm going to close it now.

If anyone has any queries please feel free to shoot me a pm :)
 
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