How toxic is Mephedrone?

[kaskelot]

Does anyone think that taking some tylenol before downing some drone would help to diminish some of its vasoconstrictive properties? Or would this just be a horrible idea?

Why would Tylenol have effect on vasoconstriction?

 

[Buddy122]

Idk, that's kinda what I was asking.

 

[bpayne]

Raw garlic will go down well with the ladies in night clubs 8). Mind you, will probably be drowned out by the reek of sweaty meph, fags and vodka (the staple diet of the young, male, ill educated meph user )[

meph users have a diet of faggots? why they gotta be homos?

 

[stom10]

Raw garlic will go down well with the ladies in night clubs 8). Mind you, will probably be drowned out by the reek of sweaty meph, fags and vodka (the staple diet of the young, male, ill educated meph user )[

meph users have a diet of faggots? why they gotta be homos?

Fags meaning cigarettes.

 

[Genasirus]

Cheers to all who posted validated, considered opinion in this thread. An associate offered me an "awesome new designer thing, like mdma but super clean with no comedown; cokestacy".

Having spent 18-23ish in the party scene and being away from it for 3+ years, Bluelight was the first place I headed and having previously avoided RC like the plague, vasoconstriction aint my bag.

Vecktor: Your contributions stand out greatly, thank you.

 

[pofacedhoe]

Raw garlic will go down well with the ladies in night clubs 8). Mind you, will probably be drowned out by the reek of sweaty meph, fags and vodka (the staple diet of the young, male, ill educated meph user )[

meph users have a diet of faggots? why they gotta be homos?

lol! when i use meph i would like a diet of faggots, mmm tasty men

 

[fastandbulbous]

According to this: http://www.thebody.com/content/art25445.html methamphetamine (and probably methcathinone) suppresses the immune system. Mephedrone is pretty close to meth, and I think a lot of drugs do this, so that's probably why you got sick. I'm sure someone with more pharmacology knowledge than me will comment soon. Don't stress about it though, sounds like you're getting better and will probably get out of this with only a harsh warning from your body.

Off the top of my head, I'd reckon that the immunosuppressing activity of various stimulants has something to do with the action of corticosteroids (cortisol being the natural version released by the body), which are one of the main culprits for the effects of stress on the body
(gastric ulcers, reflux oesophogitis, more likely to develop infections etc).


One thing that does stand out like a sore thumb in this thread though is the lengths some users (read: people with a psychological dependance) are prepared to go to to justify that mephedrone isn't that dangerous a drug, when the accumulating evidence is that it's probably one of the nastiest drugs of abuse doing the rounds at the minute. Sorry to use this cliched saying, but denial isn't just a river in Africa...


Finally...

I personally wouldn't touch this stuff with fastandbulbous's metaphorical shitty stick

Why settle for a metaphorical shitty stick when you can be the owner of the real thing, lovingly crafted by fastandbulbous and now available for orders for Xmas 2009. Guarenteed to keep all dodgy drugs, mephedrone included, at arms length!



First 50 orders also come with a fetching "meph=death" lapel badge

 

[Boojum]

hey FnB or Vecktor I would appreciate it if you guys could take a guess at what people who use meph have to look forward to as far as negative effects in the future. Especailly those who got the purple knees and such. Do you think it could have caused dermatomyositis ? It seems to closely match many of the negative effects. Do you think that after getting the pruple knees and such and being for the most part ok for a month and a half that I still have to worry about any serious future consequences after using 4 grams over three days? Much appreciation for a reply =).

it is funny you mention corticosteroids, as those are used in the treatment of dermatomyotisis, which happens to cause purple knees that come and go and a variety of other symptoms I have had since my experience with mepheedrone. I am a bit worried mephedrone can be added to the already fairly extensive list of drugs that can trigger this autoimmune order. I might get a blood test for it, if I have it I will let yall know. Sure hope I don't, even though from my research with modern medicine people who get it have an 80% chance of living 5 years and if they make it five years a high chance of it going into remission and then living symptom free for decades. So I would prefer that over like, mephedrone raping my immune system and me getting synthetic meph aids. But of course I hope it did nothing.

God I feel like a fucking comin book hero.... After a fateful mishap with a mysterious research chemical, the man known only as Boojum took to the streets, blinding evil does with his bright purple knees.

 

[euvit]

is that you from uk420.com? boojum

 

[dread]

Why settle for a metaphorical shitty stick when you can be the owner of the real thing, lovingly crafted by fastandbulbous and now available for orders for Xmas 2009. Guarenteed to keep all dodgy drugs, mephedrone included, at arms length!

Hey fnb, wanna outsource the production of the shit for those shitty sticks? I can produce huge amounts of shit every day!

 

[phatass]

No idea but i'm still alive!

 

[boptillyoudrop]

Hi guys. I did Mephedrone for the fourth time today with a cumulative dosage of around 600mg (somehow...) over around 6 hours from 2am to 8am this morning. I am still confused as to how I finished the gram off since I only remember taking a 100mg bomb and a couple of lines. This morning, at around 8am, maybe earlier, I started to notice my knees turning slightly purple. I had read about that teenager who overdosed and went blue in the face. Naturally, I start worrying a lot. It became worse and worse until my knees were completely blue and my feet were going really pale. It also happened to my arms, quite severely. I started getting confused and tired. I had developed two red rashes one on my shoulder and one on my thigh. I remember watching the blue spread across my arms until i was covering the majority of the "outsides" of my arms. I kept breathing really deeply to try and slow my heart down and get more oxygen to my body. My hands were really blotchy with red and purple. My limbs had lost temperature and were pretty numb and as I looked in the mirror my ears my pale and slightly tinted blue along with my face. I looked closely and my lips were becoming blue as well. I tried to get the energy to phone an ambulance at this point as I thought that was the end of me. However, Very VERY luckily the side effects peaked and started to subside. I lay in bed breathing deeply for around 2 more hours until my limbs were nearly the correct color. Even now, 12 hours since the first dose (and the majority) and 6 since the final dose of around 50mg, my limbs do not feel right, especially my knees. If I cross my legs now my knees start going blue.

This is the scariest experience I have ever had with drugs and it has put me off RCs for life that's for sure. I am confused as to why the problems started when the effects had pretty much gone, around the time I started coming down.

I have taken equivalent doses before and had no side effects what so ever. Does anyone know WHAT THE HELL happened to me? I'm scared that I have caused permanent damage to my cardiovascular system. I also still have poor motor skills and very slow cognition which hasn't changed since I was high.

I am left now with tachycardia, unwanted stimulation, anxiousness, depression, confusion, forgetfulness, half dead limbs, apathy and confirmation (for me at least) that Mephedrone is not worth the risk and it has serious toxic effects on the body.

and you didnt go to the hospital and get checked over- why? why? why if this happened to you and it was the scariest thing ever -feeling better or not you would go asap!!!!!

 

[fastandbulbous]

I am confused as to why the problems started when the effects had pretty much gone, around the time I started coming down.

Well the concensus seems to be that 4-MMC has a dodgy metabolite, which would account for the above (a bit like if you overdo ket, you don't get the bladder pain immediately after taking it; it generally requires a couple of hours as the toxicity is caused by a metabolite, norketamine)

hey FnB or Vecktor I would appreciate it if you guys could take a guess at what people who use meph have to look forward to as far as negative effects in the future.

That's the thing, no-one knows as 4-MMC has no real history of use in man - all of the consumption of it seems to have occurred during the last couple of years. I'm against p[rohibition, but when a drug starts to be associated with potentially really serious diseases, someone has to step in and save people from themselves as despite the incidence of really bad side effects coming to the fore, people are still taking stupid amounts in a short period of time.

This isn't in the same league as MPTP (the contaminant that caused heroin addicts in N California to develop the worst cases of Parkinson's disease after one dose), but it is starting to look like in years to come there'll be documentaries, like the ones about MPTP (BBC - Horizon - The case of the frozen addicts) detailing the long term negative consequences of 4-MMC (& possibly related compounds).

In light of the accumulating negative reports about 4-MMC, I'd reckon the smart people would avoid it like the plague as there are much safer compounds out there, even if they are illegal

 

[MurphyClox]

In light of the accumulating negative reports about 4-MMC, I'd reckon the smart people would avoid it like the plague as there are much safer compounds out there, even if they are illegal

Exactly!

Everybody else feel free to go ahead and drop your next dose. Plz take photos if some of your limbs start dying right away. Some graphical depiction of what can happen with this compound will hopefully persuade the majority of users that it is just crap.

Low price and legality are definitively arguments with lesser importance, compared to your health.

- Murphy

 

[Sparky1986]

I've used mephedrone on perhaps 7 or 8 occasions. I've never gone above a 200mg (oral) dose, nor have I redosed in 24hrs. Apart from a fair increase in heart rate & bp, I haven't noticed any significant side-effects. I must've first tried the compound around 12 weeks ago.

Responsible use (which includes not using it at all) is a major factor in reducing these horrific side effects from a scarily popular compound.

 

[Esoterik]

To put things in perspective, could anyone draw any comparisons to other well known drugs? I know a lot of what is going on here is educated speculation, but how toxic would you say mephedrone is compared to MDMA for example? Or any other stimulants?

 

[vecktor]

To put things in perspective, could anyone draw any comparisons to other well known drugs? I know a lot of what is going on here is educated speculation, but how toxic would you say mephedrone is compared to MDMA for example? Or any other stimulants?

as toxic/harmful as ephedrine with probably the same long term problems (vasoconstriction causing lack of oxygen to the heart damaging heart muscle)

much more toxic and harmful than MDMA

 

[Esoterik]

as toxic/harmful as ephedrine with probably the same long term problems (vasoconstriction causing lack of oxygen to the heart damaging heart muscle)

much more toxic and harmful than MDMA

Isn't ephedrine quite a common legal supplement? I know it's not a guarentee of relative safety, but surely if ephedrine was that harmful there would be a fair few incidents of adverse health effects making it illegal, or at least much less common? Is there something that could be taken to supplement mephdrone to counter the vasoconstriction?

 

[fastandbulbous]

but surely if ephedrine was that harmful there would be a fair few incidents of adverse health effects making it illegal, or at least much less common?

That's why the use of ephedra was banned in suppliments in the US & EU

 

[Cornishman]

I wish I had read this thread yesterday.
I had my first encounter with this stuff last night - my brain feels a bit strange today, but luckily I escaped the purple limb syndrome!

I'm now genuinely worried about my friends who're taking this stuff.
I actually had more turn up at my door this morning (seems they gave me a double order by mistake).

I'll be throwing it down the toilet after reading this thread!

Shame on the RC vendors for preying on the uneducated general public.