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mephedrone long term negative effects progress reports

B

Boojum

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Jun 16, 2007
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Ok I figure people who have had bad reactions to mephedrone can post their symtpoms here as well as progress like if you are getting better over time or whatever. Like after three months maybe you are fully back to normal. Please don't clutter this thread with things that are not you talking about your bad reaction to mephedrone, or updating on the progress of your body/effects/symtpoms/whatever since you got the bad effects.

I just posted my mephedrone experience in the, how toxic is mephedrone thread. Anyways, here is a quick run down (I am not including acute effects, please don't either)

Initial Bad Effects:

Foot discoloration (was postural dependent, happened where I had my foot pressed up against something), was bright red acutely and then turned to a deep bronze brown.

Foot swelling and engorged veins on the side of feet

Fingers were purple / dark at the knuckles, hands white as paper, tips of fingers after last joint bright red.

Oozing sores on foot opposite foot of the one with discoloration

Heart pains and light headedness, this was most noticed as an acute effect and went away fairly quickly

Purple knees

Progress report after 5 weeks:

The foot discoloration went from the dark bronze brown color and slowly faded away to a more normal color, about two shades or so different from the normal foot with a bit of a pinkish-purple-red hue to it but it is def much better. A little numb but I can still feel it.

Foot swelling greatly reduced but the veins that were engorged are still bigger and more prominent than they were.

Fingers and hands are much closer to normal color, get occasional pains in my fingers now (and feet) but its really nothing too bad and only lasts a split second at a time. Still a bit darker color in the knuckles, and a bit pinker at the tips of the fingers, but for the most part my hands actually look normal again. The knuckles the skin on them seems a wee bit more loose perhaps or this could be in my head.

All sores have healed including the most prominent one on my foot, but it left behind a perfectly round slightly indented pink scar. It is about as big as the round part on one of those tacks with the colored plastic press in part on it.

Have not really gotten heart pains since they initially went away. Occasionally I will get one very breifly but htis hardly ever happens, and I am pretty sure it happeneed before the mephedrone anyways so I am not that worried about it. I do get light headed more now though, and find myself having to take a deep breath / yawn on more occasions than I used to.

knees are pretty solidly normal colors now except for when I take a shower, in which case they turn extremely bright red or purple.

One thing I noticed is that I started getting a lot of infections after my mephedrone experience and they stayed with me for like a month before they went away. Still keeping my eye on this, praying to god I did not ruin my immune system for the rest of my life, but atm I have no signs of infection.
 
edit: Also I will update this thread with my current mephedrone related situation every month till I am back to normal or dead or stabalized for a long ass time I suppose.
 
Fingers were purple / dark at the knuckles, hands white as paper, tips of fingers after last joint bright red.
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Stop taking stims right now, you're going to have a heart attack. Purple is a solid indicator that not enough oxygen is getting to your limbs and probably organs.
 
I think you may be allergic bro cause I IV'ed that stuff for weeks at a time when I was also doing alot of Meth and the 4-MMC felt much cleaner on my body then the meth did so not sure what is up with you but its good to know these things thanks!!!
 
d-Dexter-25 said:
I think you may be allergic bro cause I IV'ed that stuff for weeks at a time when I was also doing alot of Meth and the 4-MMC felt much cleaner on my body then the meth did so not sure what is up with you but its good to know these things thanks!!!
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Allergic is def a possibility I thought of, but I think it is more likely some bio-chemistry related thing. Perhaps me and the multiple others who got similar effects lack a proper enzyme or something. I think this is more likely due to the frequency of these effects and their strange nature.

Anyways my dose pattern was 50 mg every half hour or so, 12 hours a day, for three days. That is all I ever used it for was over three days. The first negative effects (sore on foot, knees, etc) was at around hour 11 or 12 of the first day (whyyyy the fuck did I think I could keep using it!!!) which makes me also think it was not an allergy and leads me to think it is due to a metabolite with a build up in my body. I imagine that mephedrone metabolizes quickly into something else that sticks around for many hours or days. So 50 mg the first time didn't cause problems, but led to X amount of metabolite. Then each dose after that led to the metabolite being present in X * amount of doses which eventually lead to toxic symptoms. Perhaps some people can handle the metabolite, and others are lacking an enzyme to deal with it, or can not remove it from the body fast enough. I mean if 50 mg does nothing bad to me, and then 50 mg a half hour later does nothing bad to me for 9 half hour repeats, it makes little sense that at hour 11 I am suddenly going to have an allergic reaction, or sudden onset of symptoms directly related to mephedrone. I am not a scientist, this is all just guess work, but I am betting on this being the cause (a small but significant subset of the population lacking the proper biochemistry to quickly remove some toxic mephedrone metabolite. This would lead to people only getting negative effects if they use a large dose and are hit with a large amount of the metabolite at once before their body can process it, or if they use smaller doses with a large amount of frequency and their body can't adequately remove the metabolite in a timely fashion, leading to build up of the metabolite to toxic levels over time).

Another thing that leads me to think this is that in many (but not all) of the cases of serious negative symptoms, the symptoms arose AFTER the high was already done with. This leads me to think even more so that it is a metabolite causing the issues and not mephedrone directly.

I just want to also take a second to reassure people who may be experiencing similar side effects, that at least in my case they seem to be slowly subsiding over time and get a tiny bit less every day, If I make as much 'progress' over the next 5 weeks as I made over the past 5 weeks I think I will be close to normal (ie: close to how I would be if I never used mephedrone). And I am really hoping for this. I would really appreciate anyone else who got the pruple knees etc.. if you would post your progress here too as I am very interested in it, especially if you got the onset of symptoms two months ago or longer, so I can see what to hopefully expect for myself. Am hoping you continued to get better. My biggest worry right now is that I caused some permanent damage to myself, the extent of which I will not realize for many more months or years or something. I knew this was a risk I was taking when I tried a research drug, and I accept I was stupid as fuck with it. but I am hoping people can research this drug, or people with negative effects such as the purple knees, can post their stories and share their progress, to help put everyones mind at ease (or, in the worst case scenario, find out that we actually did cause ourselves some serious problems, but at least find out what the problems are so we don't need to live in uncertainty).

I also whole heartedly suggest people stay as far away from this drug as possible. You make your own choices in life and have the right to use what ever you want. But don't say no one ever warned you if you come down with these symptoms. The high of mephedrone is fun, but it isn't even worth the *chance* that this will happen to you. If it does happen to you, you will have nothing but regrets about using it. I do not think mephedrone is a safe drug for anyone, and I really wish people would stop marketing it so intensely (in some cases even spreading false information on it, which I see a lot doing) with so little actual REAL information on it.
 
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I wouldn't go that far, but I'd definately treat it with a similar level of caution as something like MDMA and keep it as a once a month, no more than half a gram kind of thing.
 
^It seems to be a lot physically more dangerous then MDMA.

Anyway, F&B's refusal to take it has largely prompted my own desicison..
 
Seems that drone affects people very differently. I've taken anywhere from 200 to 750mg in a night over a few hours and have only managed the basic stimulant effects. But i have read of people, on a normal dose, turning blue and having chest problems. Although it does seem that these drastic negative side effects tend to happen more in those that greatly abuse this drug, be it by using too much at once, or too frequent. I think this is a good thread though, may enlighten people.
 
To the OP and all others experiencing toxic effects from mephedrone - my heart goes out to you and hope that you recover fully and good on you for documenting it. People choosing not to touch it - smart choice.

I like mephedrone but I certainly treat it with care. This is more of a general statement but all of these RC's prepared in anonymous laboratories in unregulated countries carry the risk of unwanted and dangerous impurities. This is less of an issue for the 2C-I's etc. because the doses are so much lower. The reports of mephedrone being "yellowish" and having an "odor" are very scary to me and indicate careless manufacturing! I know we are not supposed to talk about drug synthesis but I've prepared myself >99.9% pure mephedrone and didn't notice any adverse-effects aside from the normal body load assoicated with most amphetamine/ beta-ketone type compounds. People treat MDMA with caution and they should do the same with mephedrone and some of these 3-4 day binges of more than 5 grams that people are going on are ridiculous and dangerous.

The mephedrone problem and others to come in the future are directly a result of the crackdown on MDMA - it causes people to look for alternatives which can end up being much more dangerous. It would be great it we could have some true toxicology studies on mephedrone instead of anecdotal reports. My 2 cents.

PS: One potential major impurity in mephedrone is 3-methylmethcathinone, even up to 10%
 
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swilow said:
^It seems to be a lot physically more dangerous then MDMA.

Anyway, F&B's refusal to take it has largely prompted my own desicison..
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Not that it means anything,I took (only 2-3 times though) and felt safe with bk-PMMA but I never persued Mephedrone.Just intuition and I'm usually not too shy to take some risks.It appears that it takes at least one or two methoxi groups to "sterilize" a 4-Methylamphetamine (and I'm still not 100% ok on DOM to be honest).How is agranulocytosis be found out?
 
I think I've only seen one report of long-lasting side effects from a single normal less than 300mg dose. Perhaps one of the deaths were from a single normal dose too?

However, every other report seems to be after having redosed and taken a combined dosage of 500mg or 1000mg or more.
 
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and I'm still not 100% ok on DOM to be honest
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Considering the dose of DOM for effect is in the single figures of milligrams as opposed to hundreds of milligrams for 4-MMC, I somehow think that DOM will be devoid of any such side effects unless taken at massive (stupid) doses - the sort of dopse where the psychiastric effects will be the paramount concern
 
I really don't think this drug is safe. Not sure why it was ever chosen to be produced. I'm sure the person who discovered this and mass marketed it is out there on the internet since that's where it's mostly available, so tell us some day.
 
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