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Aphrodisiacs of the Future

Any stimulant compound is aphrodisiac whereas any depressant tends to have the opposite effect.

Dont try and hammer me with exceptions, but I regard the above claim as a valid generalization.

I also read in a paper by Ennio Esposito that the 5HT2C agonist mCPP produces penile erections in rats.
 
Another question not really relevant to "the future" but anyway..

I have not personally tried NaBr although I have read alot about it suppressing sex drive.

Maybe there are other simple "salts" that have physiological effects, I dont know.

That is my question is what do people know about this?
 
Smyth said:
Another question not really relevant to "the future" but anyway..

I have not personally tried NaBr although I have read alot about it suppressing sex drive.

Maybe there are other simple "salts" that have physiological effects, I dont know.

That is my question is what do people know about this?
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it is bromide anion, the cation is irrelevant, and it works by a very general depressant mechanism although the bromide in army tea thing appears to be a myth.
wouldn't suggest taking bromides as there are a whole pile of adverse effects.
 
Artificial Emotion said:
Why is GHB and related compounds an aphrodisiac?
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Well, principally GHB is an agonist of the GHB receptor and, secondarily, an agonist of the GABAB receptor. The former receptor stimulates the release of various monoamines upon activation and the latter inhibits their release. In other words, GHB at lower doses is a CNS stimulant and at higher doses is a CNS depressant.

A more interesting question is why Alcohol can act as an aphrodisiac.
 
Ason Unique said:
If you ask me Cannabis is a pretty good aphrodisiac by itself, I always get really horny if I just start to think about anything sexual. I find that if you do it during your high it kinda kills it though, so I do it when its about to wear off, but the aphrodisiac effect remains.
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For sure dude. Cannabis is an Aphrodisiac and the only one i tried that actually makes you horny and want to have sex or whack off :|
 
Artificial Emotion said:
Why is GHB and related compounds an aphrodisiac?
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It is rumored to be popular on the gay scene like amylnitrate is because it helps loosen up the sphincter prior to fisting.

I also saw on the news that crystal meth is an extremely popular gay drug in London nightlife although it wasnt clear what the reason for this was.

I think because it is appetite suppressant it reduces the likelyhood of having to much shit in your intestines.
 
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shibireru said:
Well, principally GHB is an agonist of the GHB receptor and, secondarily, an agonist of the GABAB receptor. The former receptor stimulates the release of various monoamines upon activation and the latter inhibits their release. In other words, GHB at lower doses is a CNS stimulant and at higher doses is a CNS depressant.

A more interesting question is why Alcohol can act as an aphrodisiac.
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I suppose anything that causes disinhibition can act as a mental aphrodisiac, because humans are fucked up creatures that use complex societal structures to repress sexual behaviour witness bonobos as a contrast.
ghb has a dual mode of action here, it cranks up the extracellular dopamine levels whilst also causing disinhibition, though dopamine alone a la MDPV (methylenedioxypervertamine) is rather effective.
 
Smyth said:
I also saw on the news that crystal meth is an extremely popular gay drug in London nightlife although it wasnt clear what the reason for this was.

I think because it is appetite suppressant it reduces the likelyhood of having to much shit in your intestines.
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^ in contrast to the amount of shit you spout in your posts
 
Yeah, it's well known.

Thought to largely explain the recreational effects of GHB since other GABAB ligands aren't really.
 
Have yohimbine derivatives been explored for this type of action yet?
 
Three years ago Wyeth came out with a patent for a bunch of prosexual piperazines that were serotonergic in nature (5HT1A antagonists). Strangely it appears it was being developed to treat the antisexual side-effects of fluoxetine. They do seem to induce a small advantage as compared to placebo.
 

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Dopamine D2 receptor agonists (and to some extent D1 agonists) prevent prolactin elevation for males and females post-orgasm and enable multi-orgasmic behaviour. Sumanirole, a D2-specific agonist, was being developed by Pfizer but was dropped after human trials because it failed to be any more efficacious than current compounds for Parkinson's disease or restless leg syndrome. That it made it into human trials probably indicated that the rat toxicology looked good. A cost effective and biosynthetically interesting synthesis had appeared in literature in 2002.
 
EN21 said:
I just wondered why nobody mentioned the phenylpiperazine filbanserin. http://en.wikipedia.org/wiki/Flibanserin
From a structurally point of view, this could be a beginning for new compounds.
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Yes, these have high potential as well. I am pretty sure the prosexual activity is related to their ability to act as 5HT1A agonists and 5HT2A antagonists. US Patent 6,521,623 from Boehringer Ingelheim Pharma KG describes analogues of Flibanserin in detail. In particular one stands out, which is included in this post. The metabolic stability of the amide/ester may not be good, particularly orally.

Judging from the SAR data I'd guess the following analogues are also active and similar to the parent compound flibanserin:
1-[2-[4-(3-ethyl phenyl) piperazin-1-yl] ethyl] benzimidazol-[1H]-2-one
1-[2-[4-(3-methyl phenyl) piperazin-1-yl] ethyl] benzimidazol-[1H]-2-one
1-[2-[4-(2,3-dimethyl phenyl) piperazin-1-yl] ethyl] benzimidazol-[1H]-2-one

Going from the reports of this stuff from the clinical trials it's probably pretty recreational.
 

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I found this discussion very interesting. My girlfriend who is Thai told me a few years ago about an experience she had with an old boyfriend who injected a liquid anally. She started becoming very sexually aroused in 10 or 20 minutes, including considerably increased spontaneous vaginal lubrication. She had a resulting intense sexual drive for several hours (long outlasting her old boyfriend's stamina). She didn't know what it was, and I had often speculated, given the ubiquity of drugs in Thailand, that perhaps it was crystal meth. I haven't heard of an aphrodisiac like this and was wondering if there might be other ideas what this could have been.
 
Smyth said:
It is rumored to be popular on the gay scene like amylnitrate is because it helps loosen up the sphincter prior to fisting.

I also saw on the news that crystal meth is an extremely popular gay drug in London nightlife although it wasnt clear what the reason for this was.

I think because it is appetite suppressant it reduces the likelyhood of having to much shit in your intestines.
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Apparently ketamine is used for the same purpose, to facilitate gay but-fucking.
 
traveler3871 said:
I found this discussion very interesting. My girlfriend who is Thai told me a few years ago about an experience she had with an old boyfriend who injected a liquid anally. She started becoming very sexually aroused in 10 or 20 minutes, including considerably increased spontaneous vaginal lubrication. She had a resulting intense sexual drive for several hours (long outlasting her old boyfriend's stamina). She didn't know what it was, and I had often speculated, given the ubiquity of drugs in Thailand, that perhaps it was crystal meth. I haven't heard of an aphrodisiac like this and was wondering if there might be other ideas what this could have been.
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Methamphetamine tends to make ladies crazy dry, or at least that's been my limited experience.

So anyway, these 5HT1A partially agonizing compounds like flibanserin appear to only exert their effects after administration for 3-6 weeks, apparently, but that's what they said about SSRIs and then after a review of the data said 1-2 weeks was plenty. I'm not sure how they work -- 5HT2A activity is generally robust and will return to baseline after chronic administration of antagonists, but 5HT1A agonist cause some kind of long term desensitization.
 
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