Opiates, SSRIs and Serotonin Syndrome

[Kava-Kava]

Swim took 100mg tramadol and is taking low doses of zoloft (Sertraline), the effects are pleasurable and worrying at the same time, i searched for any contraindications after the tramadol was taken. It appears that SSRIs affect opiates and tramadol among other drugs. Is this true and what are the effects?

 

[permastoned]

You will be fine, they both are SSRIs but combining two SSRIs generally won't cause serotonin syndrome, it can, but its very rare. Usually it needs to be two serotonergic drugs with separate mechanisms of action.

 

[Kava-Kava]

Last night i felt happy, for the first time in a while so i took 100mg tramadol today as well as my regular Sertraline. I feel good. I read they are both substrates of CYP2D6.

I phoned a friend and asked whether it was a good idea to take the tramadol again today, he said it was stupid on both counts of last night and today. Does Tramadols bioavailability increase with repeated doses?

 

[permastoned]

It is not dangerous acutely but it can be dangerous in that you might get addicted to tramadol. Like any other opioid, it is addictive, plus on top of that its an SNRI so it is addictive in two ways. The happiness is most likely just opioidergic effects. Have you ever taken an opioid before? Like codeine, morphine, heroin etc.?

 

[Kava-Kava]

Im a recovering heroin addict, i was on bupe then done but now im off it all. I have been severely depressed for months and the zoloft is starting to help.

 

[permastoned]

That's a good thing to hear. If you have been addicted to opioids before its unlikely that 100 mg of tramadol would be causing any great opioidergic affects so you may be on to a winning combination of drugs to take daily.

 

[pofacedhoe]

Swim took 100mg tramadol and is taking low doses of zoloft (Sertraline), the effects are pleasurable and worrying at the same time, i searched for any contraindications after the tramadol was taken. It appears that SSRIs affect opiates and tramadol among other drugs. Is this true and what are the effects?

tramadol is not an ssri, it has effects on serotonin

 

[Hammilton]

and the sky isn't green, it's blue, but no one said anything about that either.

Yeah, for some reason anything that inhibits 5HT reuptake is an SSRI to most people.

 

[permastoned]

sorry, it is not an ssri but it IS an SRI, its the drug companies' faults that anything that is an SRI makes me say SSRI just because thats the acronym they have given those drugs