do you have any sources to back this up? i mentioned this to my doctor and he said that is not true. he said he's seen people prescribed up to 64mg's in order for the Subs to stop the W/D. according to your statement that would be causing an antagonistic effect instead of helping the W/D.
It varies for individuals. Not everyone can get relief from the same low dose of buprenorphine that I can.
Some people require higher amounts, some people require lower ones.
The idea is that not everyone needs a higher amount either.
If you don't NEED a higher amount, buprenorphine can antagonize itself at the mu-opioid receptor. There is evidence of this, hence why it is called a partial agonist/antagonist. If you talk to your doctor about this, he's likely to say that the partial agonist/antagonist means that the antagonism comes from naloxone, when we all know thoroughly well by now that naloxone is an, in essence, inert ingredient in suboxone. Buprenorphine is itself a partial agonist/antagonist due to the fact that it can both agonize and antagonize the receptor, though at the right dose it will just agonize it.
I wouldn't trust your buprenorphine doctor to know much about his "area of expertise", because by far and large, most buprenorphine doctors don't know anything about what they're talking about.
Most people who post "I talked to my bupe doctor and here's what he told me..." contradict in what they say following these words so much that anyone can clearly see that only rarely do buprenorphine doctors know what they're talking about.
And yes, there is antecdotal evidence to suggest what I am talking about is true. There was someone who saved up his N8's from a take away clinic (probably down under...but who knows...you Aussies are crazy
) and ended up taking something like > 11 8mg pills (over 88mg), and the buprenorphine most certainly was antagonizing him. He was agitated, and came into the clinic demanding more, and upon being given two more, he asked for more, upon time they decided to further investigate the situation.
If someone knows the story I'm talking about, feel free to post the story, I can't seem to find it.
Righteous post bro. Man did I ever learn my lesson.
As far as bupe antagonising itself at higher doses that would be case dependent. If someone needs 2000mg legitimately than no the bupe won't antagonize itself. The idea is that once a person goes beyond a certain dose the bupe could antagonize itself. Saying someone has needed 64mg doesn't prove or disprove anything. Without reading this entire thread from 3 months ago I'm pretty sure that idea was presented as an abstract. Meaning it hasn't been proven or disproved yet.
I think it's pretty much been proven (short of pictures of the neurotransmitters in action). I've seen it when people take too much buprenorphine; they get really itchy, they get tired, they get irritable, they're agitated, they're angry/upset, and not in a good mood.
