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Selegiline + Wellbutrin

^ That doesn't make your dick any bigger than mine 8)

Seriously, taking a full dose of amphetamine with a total-inhibitory dose of selegiline makes as much sense as downing a bottle of vodka before IVing Heroin.

--

Smyth: No, I have taken Selegiline before, forgot my maximum dose but definitely never gone above 10mg.

MAOIs are not a joke. I really don't understand how people play with them like toys.
 
^ Only the levorotatory forms which are pretty much centrally inactive (crap)

I wasn't dick sizing. Actually I was pointing it how hopeless my situation is that my dopamine/norepi receptors are that down regulated. Unfortunately I am one of a kind.. genetically fornulated to be a junkie. I take it for adhd and the effects completely disappate by the third day.

I have a naturally high opioid tolerance. Drank a 200 ml bottle of dihydrocodeine(Rikodeine) whilst opiate naive and ogt an excruciatingly depressing lack of effects (not just eupgoria, all the others too).

Woe is me. Dno how I'm gonna get through med school.
 
bring this thread back on topic or it disappears.

that means sensible discussion rather than Kewl posts about how much drugz you can take coz ur a man.
 
In the article I was just reading in fact, it says that depressed individuals are likely to need high doses of selegiline because it is not until you start inhibiting the A isoform of the MAO enzyme that 5-HT and noradrenaline metabolism can be obstructed.

For this reason, since rasagiline is even more selective for MAOI-B that selegiline, it is difficult to contemplate that rasagiline could be used for the treatment depression.
 
^sigh... I don't think of myself as manly at all. I'm bisexual and wear very non 'manly' clothing.

I guess my suggestion with amp or amp+seleg, take it for a few days then stop for 2 days.

In addition take magnesium or memantine(expensive). Magnesium should be the chelated form.
 
jamshyd said:
That doesn't make your dick any bigger than mine

Seriously, taking a full dose of amphetamine with a total-inhibitory dose of selegiline makes as much sense as downing a bottle of vodka before IVing Heroin.
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A full dose? More like 7 full doses. ;) Really. What the hell?

Only the levorotatory forms [are metabolites of l-selegiline] which are pretty much centrally inactive (crap)
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And given the dose range of selegiline, these are tiny amounts. Well, maybe not if you take 30 mg (jeezzzus). You'll test positive for amps if taking drug-tests though.
 
In the article I was just reading in fact, it says that depressed individuals are likely to need high doses of selegiline because it is not until you start inhibiting the A isoform of the MAO enzyme that 5-HT and noradrenaline metabolism can be obstructed.

For this reason, since rasagiline is even more selective for MAOI-B that selegiline, it is difficult to contemplate that rasagiline could be used for the treatment depression.
Click to expand...

Why do you assume that 5ht and NE systems underlie depression but not DA? The main piece of evidence supporting the 5ht theory of depression is the efficacy of SSRIs. SSRIs appear marginally effective in studies with active placebos. This is weak-ass evidence. :)
 
ebola? said:
Why do you assume that 5ht and NE systems underlie depression but not DA? The main piece of evidence supporting the 5ht theory of depression is the efficacy of SSRIs. SSRIs appear marginally effective in studies with active placebos. This is weak-ass evidence. :)
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How can a placebo be considered "active" ?

http://dictionary.reference.com/browse/placebo

I'll get the quote from the paper I was reading later. Maybe the author also had a reference im not sure.
 
Smyth said:
How can a placebo be considered "active" ?

http://dictionary.reference.com/browse/placebo

I'll get the quote from the paper I was reading later. Maybe the author also had a reference im not sure.
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It would help if you typed in "active placebo" instead of "placebo". That is how online dictionaries work :|

generally an active placebo is another drug that produces some effects on systems different to the target system, usually peripheral effects. for example nicotinamide is an active placebo.
 
PetersKeys said:
Only in the Old Testament. The New Testament God starts to be more forgiving and loving :)

I think he meant 300mg and not 3000mg. 3000mg would almost definately be seizure zone for wellbutrin.

If it was 3000mg, wow. I myself can't even handle 300mg, lol.
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1. i was prescribed 300 mg,
2. i didn't do a direct ingestion of 300 mg, i took 10 300 mg pills that are TIME RELEASE and lasted 72 hours, it would be as if i sniffed like 300 mg, sorry for not making that clear
3. i saw an experience report on erowid that said 3000 mg was a GOOD DOSE. now this obviously is in the same case scenario as me with time release capsules and not direct ingestion. i was vomiting though cuz the coding on the generic bupropion is nasty as fuck
 
Bupropion is expensive even generic.

I can barely see how you could afford to gulp that much down since it should have lasted you at least 1 week.
 
i didn't do a direct ingestion of 300 mg, i took 10 300 mg pills that are TIME RELEASE and lasted 72 hours, it would be as if i sniffed like 300 mg, sorry for not making that clear
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The math doesn't work out like this.

ebola
 
true that,,.. if he is indeed correct that the pills are 72 hour time release, which I find to be highly unlikely. if that were the case, then yes, he would have onlyl absorbed 42 mg or so per hour.

Rather, I think it would be likely that they were 12 hour time release (any more would not make sense for sleeping!), which just happened to have subjective effects that LASTED 72 hours. This would give an absorption of roughly 250mg every hour. Still defintely not the same as snorting 300mg.

When you absorb the drug in such a slow way like this, your body is constantly adapting to it, causing a tachyphylaxis, hence the reason why you had a terriblly long boring trip.
 
Sorry to put this here but has anyone taken Seroquel with selegiline? I am taking 2.5 deprenyl and due to inability to sleep, want to take 100 seroquel with. Anyone aware of negative sides?
 
permastoned said:
^ that will be fine... it will mostly counteract the effects of the seleg. But bewarned seroquel can have bitchy side effects on it's own, Akathisia is fucking horrible
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I have taken seroquel for a while for sleep issues and with the added deprenyl, feeling better but sleeping less. I am amazed that I have been able to go from 3mg xanax ed to 1mg ed while being on Deprenyl. It has been 3 days now.

Thanks
 
jcee said:
I have taken seroquel for a while for sleep issues and with the added deprenyl, feeling better but sleeping less. I am amazed that I have been able to go from 3mg xanax ed to 1mg ed while being on Deprenyl. It has been 3 days now.

Thanks
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hey jcee, that is great news that you were able to cut ur xanax dose by such a large proportion due to the selegiline. Try to establish good routines and habits now while you can, because the effect of the selegiline will EVENTUALLY wear off, and u will need to rely upon those habits that u have established during its period of efficacy.
 
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