Research Project Ideas

[Matt the Raver]

Another thing is what's the timescale? Are we talking 3-6 months?

Also, I know this isn't an exciting way of looking at things, but the most important thing for a project is how well you get on with you supervisor? Then what techniques are you going to be using?

The theoretical background comes third. Simply because on a day to day basis, you need to be more concerned with gaining competence in the techniques you're using before you can theorise about what your data means or what would be cool to look at.

 

[IGNVS]

do some case studies on the effects of psychedellics on savants (probably unlikely that you could do something like that but it sure would be intresting to know, imagine all the stuff you could learn)

 

[almost-]

I would love to study psychoactive effects of sigma-agonists, kappa-agonists, and mGLU-agonists and antagonists.

Your Favorites
Cat. No. Product Name & Pharmacological Action
0924 (+)-MK 801 maleate
Non-competitive NMDA antagonist, acts ion channel site
1251 SDZ 220-040
Potent, competitive NMDA antagonist
0379 SKF 97541
Extremely potent GABAB agonist
0469 Nitrocaramiphen hydrochloride
Muscarinic antagonist, M1 > M2
0482 4-DAMP
Muscarinic M3 antagonist
1105 AF-DX 116
Selective M2 antagonist
1425 (S)-(+)-Dimethindene maleate
M2-selective antagonist
0351 1-Acetyl-4-methylpiperazine hydrochloride
Nicotinic agonist
0421 GBR 12909 dihydrochloride
Selective DA uptake inhibitor. Also s ligand
0702 BTCP maleate
Potent dopamine uptake inhibitor
0495 (±)-U-50488 hydrochloride
Standard selective k agonist
0699 BRL 52537 hydrochloride
Potent and selective k agonist
0778 ICI 199,441 hydrochloride
Potent k agonist
1419 Naloxone benzoylhydrazone k3 agonist. Antagonist at m, d, k1 and ORL1
0620 4-PPBP maleate
Specific s ligand, NMDA antagonist
1483 GR 89696 fumarate
Subtype-selective k opioid agonist
1497 Rimcazole dihydrochloride
s2 antagonist. Also DAT inhibitor
1801 WAY 161503 hydrochloride
Potent, selective 5-HT2C agonist
1854 Ro 60-0175 fumarate
Potent, selective 5-HT2C agonist
0589 PRE-084 hydrochloride
Highly selective s1 agonist
2173 WAY 629 hydrochloride Selective 5-HT2C agonist
2201 PNU 22394 hydrochloride 5-HT2C agonist and 5-HT2A/2B partial agonist
2134 Salvinorin A Highly potent and selective k-opioid agonist
2453 LY 379268 Highly selective group II mGlu agonist
2456 Co 101244 hydrochloride Highly selective NR2B antagonist

http://www.tocris.com

 

[francophile]

Ia there anyone who's tried this 2201 PNU 22394 compound? Sounds quite promising, and pretty easily obtainable....

 

[Hammilton]

Since it's almost certainly going to be considered an analogue, I don't see many being too interested.

I would love to see binding data on 1-(benzo[d][1,3]dioxol-5-yl)propan-1-amine


^ You're three years late to be suggesting.

Still, anyone with a little money can have things screened.

 

[LabRatNW]

Ia there anyone who's tried this 2201 PNU 22394 compound? Sounds quite promising, and pretty easily obtainable....

I'd worry about binding by the 'terminal' nitrogen. The 7-membered ring may create some steric hinderence... But it would be worth testing on the 5-HT class receptors, as far as psychedelia is concerned, the alkylated indolic nitrogen may also mute some of that, as Shulgin showed that its not a terribly effective site for producing effects in tryptamines. Lengthening the chain may make it effects similar to the JWH compounds.

 

[Hammilton]

jesus, it's already been tested. It's a 5HT2a partial agonist.

Running theme tonight: READ

Potent 5-HT2C agonist and partial 5-HT2A/5-HT2B agonist. Non-selective between 5-HT2 receptor subtypes (Ki values are 18, 18 and 66 nM for human recombinant 5-HT2C, 5-HT2A and 5-HT2B receptors respectively). Reduces food intake in rats following subcutaneous administration and displays anorexigenic effects in humans.