• N&PD Moderators: Skorpio

Sperm is Antidepressant?

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The natural products industry could make a killing out of this. "Facial cream that soothes and rejuvenates, leaving your complexion tender and your mood happier - NATURAL INGREDIENTS ONLY"
 
The natural products industry could make a killing out of this. "Facial cream that soothes and rejuvenates, leaving your complexion tender and your mood happier - NATURAL INGREDIENTS ONLY"

How are they gonna make any money off that when I am giving it out for free?
 
Women who have unprotected sex may be happier, but I don't think that means semen is an antidepressant.
 
God this thread is constantly getting better.

now insufflating semen has been suggested.

I don't think this would be something likely to be approved- as I recall, anything involving human tissue secretions is automatically under FDA control.
 
Lets not let this thread die just yet. Here's a bit more wood for the fire:

Med Hypotheses. 1986 Jun;20(2):221-31.
The intravaginal absorption of male generated hormones and their possible effect on female behaviour.
Ney PG.

In this paper I hypothesize that a woman through her vagina absorbs sufficient quantities of the prostaglandins from her partner's semen, to affect her mood. The vagina appears to have an active transport mechanism which readily absorbs the hormones found in seminal plasma. The seminal secretions include estrogens, F.S.H., LH, testosterone, and at least 13 prostaglandins. Prostaglandins have a modulating effect on neurotransmitters. Evening Primrose Oil (E.P.O., Efamol) may improve depressed mood by facilitating the production of prostaglandins. I have described a depressed, child abusing mother who was possibly getting insufficient exogenous prostaglandins post-partum to maintain her pre-partum mood state because she was avoiding intercourse with her husband. When her mood improved on E.P.O., she began enjoying her husband and her child. If these observations and deductions are correct, regular amounts of seminal plasma may be important in maintaining a woman's affective health and E.P.O. may be useful in treating depressed abusing mothers.

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Active transport?!? That's actually pretty cool. A little more on the magical biochemical entity that is the female vagina (and you thought it was just there for teasing... you all should know by now that nature makes optimal use of everything):

Drug Metab Rev. 1983;14(2):137-68.
Absorption from the vagina.
Benziger DP, Edelson J.

PIP: Methods and results are reviewed of research on the permeability of the vagina to a wide variety of compounds including steroids, prostaglandins (PGs), antimicrobials, proteins, antigens, and hormones, nonoxynol-9, methadone, and inorganic compounds. Although the literature indicates that the vagina is capable of absorbing a wide variety of organic and inorganic compounds, quantitative data on the extent of absorption are often lacking. Most steroids were readily absorbed and their bioavailability after intravaginal instillation was greater than after oral administration because of a reduced first-pass effect. Natural and synthetic PGs were absorbed; the extent of absorption ranged from 10-43% of the dose. Penicillin and sulfanilamide exhibited extremely variable absorption from the vagina. In most women neither econazole, miconazole, nor clotrimazole were effectively absorbed. In 1943 it was demonstrated that proteins could be absorbed from the vagina. Data on human absorption of nonoxynol-9 are indirect but are consistent with absorption. Methadone, povidone-iodine, and potassium permanganate have also been shown to be absorbed through the vagina. The stage of the reproductive cycle may alter the extent of vaginal absorption, but this has been clearly demonstrated for only 1 substance in the rat.

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J Control Release. 2005 Mar 21;103(2):301-13.
The vagina as a route for systemic drug delivery.
Hussain A, Ahsan F.

Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University, Health Sciences Center, 1300 Coulter Drive, Amarillo, TX 79106, USA.

Exhaustive efforts have been made toward the administration of drugs, via alternative routes, that are poorly absorbed after the oral administration. The vagina as a route of drug delivery has been known since ancient times. In recent years, the vaginal route has been rediscovered as a potential route for systemic delivery of peptides and other therapeutically important macromolecules. However, successful delivery of drugs through the vagina remains a challenge, primarily due to the poor absorption across the vaginal epithelium. The rate and extent of drug absorption after intravaginal administration may vary depending on formulation factors, vaginal physiology, age of the patient and menstrual cycle. Suppositories, creams, gels, tablets and vaginal rings are commonly used vaginal drug delivery systems. The purpose of this communication is to provide the reader with a summary of advances made in the field of vaginal drug delivery. This report, therefore, summarizes various vaginal drug delivery systems with an introduction to vaginal physiology and factors affecting drug absorption from the vaginal route.

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