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How toxic is Mephedrone?

closedeyevision said:
to go back to topic- mephedrone can = methemoglobinemia, anyone?
this haapens with some of the substituted amphetamines and a lot of the anecdotes of people turning blue etc sound a lot like it.

indeed here in scotland, two people were hospitalised with the condition after comsuming what they said was cocaine. A warning went out suggesting a contaminated batch of C, could it be they were hoofing mephedrone instead?
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It's too difficult to say. It could have been so many different things for gods sake.
 
closedeyevision said:
to go back to topic- mephedrone can = methemoglobinemia, anyone?
this haapens with some of the substituted amphetamines and a lot of the anecdotes of people turning blue etc sound a lot like it.
Click to expand...

What substituted amphetamines cause methemoglovinemia? I've never heard of this happening.
 
I doubt anyone read my post made earlier but i have a large addendum/
REVISION
I admit to getting it completely wrong.
Cinnarizine's only theraputic use is as an anti-emetic: one sharing the d-2 antagonism common among neuroleptics, and have since found one or two cases of extra-pyramidal symptoms in short-term use.

And Niacinamide which I also mentioned is useless as ot doesn't produce vasorelaxantion/dilaton or blood pressure lowering that its parent drug niacin does.

Propranolol is also contraindicated in cns stimulant use. As in asthmatics taking ephedrine. Here's a lazy and lazily referencered section on the subject from (erowid http://www.erowid.org/pharms/betablockers/)

The alpha-adrenergic receptors control vasoconstriction while beta-adrenergic receptors control vasodilation. If a beta-selective chemical blocks the beta-adrenoreceptors while leaving the alpha-receptors unaffected and a stimulant is taken that would normally act on both alpha- and beta-receptors, there is the potential to cause a dangerous imbalance.

What did work actually was Viagra. I had some painful tightness and high blood pressure in my arm/wrist from nerve damage there. It definitely brought blood pressure in the arm and in general back down to normal, returning feeling etc. and no probs with hypertension or constriction were experienced.

I do worry though that my sinuses (sinii?) will forgive me for all the experimental re-landscaping work (a la thiepvalle ridge) done on them. STINGER
 
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closedeyevision said:
to go back to topic- mephedrone can = methemoglobinemia, anyone?
this haapens with some of the substituted amphetamines and a lot of the anecdotes of people turning blue etc sound a lot like it.

indeed here in scotland, two people were hospitalised with the condition after comsuming what they said was cocaine. A warning went out suggesting a contaminated batch of C, could it be they were hoofing mephedrone instead?
Click to expand...

mephedrone has been known to cause a tanned darker skin look and excessive use can leave me short of breath and dizzy...
 
My friend died from taking what may have been a recreational dose of mephedrone or bk-mdma last week and his body was found on the wednesday. Sorry, I don't want to talk about it - I thought I'd just contribute my two cents. I was thinking of suing the company that made it but that's just me wanting someone to blame, which is wrong.
 
Artificial Emotion said:
My friend died from taking what may have been a recreational dose of mephedrone or bk-mdma last week and his body was found on the wednesday. Sorry, I don't want to talk about it - I thought I'd just contribute my two cents. I was thinking of suing the company that made it but that's just me wanting someone to blame, which is wrong.
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I'm so sorry to hear this.
PM me if you want to talk.

Please people, either be super careful of leave mephedrone alone until we understand it some more.
 
Artificial Emotion said:
My friend died from taking what may have been a recreational dose of mephedrone or bk-mdma last week and his body was found on the wednesday. Sorry, I don't want to talk about it - I thought I'd just contribute my two cents. I was thinking of suing the company that made it but that's just me wanting someone to blame, which is wrong.
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I'm sorry to hear about your loss, and I'm sure all who read your post are. Your conclusion about the contemplation of going to blame someone is wise. But if after the acute phase you realized that some positive action amongst all the grief is possible, you would hopefully be inclined to release more information. Thinking of it, withdrawing information on the vendor, closer details on the "recreational" dosage, and even speculation on what level 4-MMC or bk-mdma was the cause of death, is likely to be a major factor in contributing towards further harm caused by these substances. Usage and discussion about them is frenzying, and your information could very well save further lives. Death from plain mephedrone or methylone usage is (unfortunately) big and sad news, from which thousands of people could (fortunately) benefit. I wish you strength.
 
Whenever I take this drug I can't help myself from picking the stubble out of my chin constantly. Is this considered to be stereotyped behavior commonly associated with psychostimulants?
 
If I recall right, excessive grooming is an effect on stimulants on rats...
 
Sparky1986 said:
Artificial Emotion, I'm very sorry for your loss. It looks like mephedrone is a chemical where harm reduction MUST be practised, regardless of speculated toxicity.
_

I happen to know of a (popular) legal high product in the UK which contains mephedrone, it also has a herb called "hoodia" in it which I believe is a weak MAOI. Would anyone know why?

From what I've read combining stimulants/SERT releasers or modulators and MAOIs could be harmful (does anyone have any good citations for this?). Is it possible the "hoodia" is present to reduce vasoconstriction or other body-load effects?

_
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I am not aware of hoodia being a MAOI, hoodia is a toxic weight loss supplement which contains a complex neurosteroid looking thing called P57 which screws with the hypothalamus and other areas of the brain that sense hunger. unfortunately as several pharma companies discovered it also shows hepatotoxicity and the appetite suppressant activity cannot be separated from this toxicity. the herb itself is prohibited for sale as appetite supressing supplements by the EU.
 
Artificial Emotion said:
Whenever I take this drug I can't help myself from picking the stubble out of my chin constantly. Is this considered to be stereotyped behavior commonly associated with psychostimulants?
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I know plucking at hair has been commonly seen with people who abuse ritalin (and I am pretty sure adderall as well,) but these are stimulants that are meant to make people focus. I don't know about this in regards to mephedrone though, and it might be hard to find anything on it because it's so new.
 
I do it normally when people aren't looking. How do I get rid of this bizarre habit? I can't stop myself. Stimulants make me to it CONSTANTLY, even when people aren't looking. I also eat the stubble. I know this sounds rediculous but I assure you I'm being honest. At least I don't pick my nose and eat it.
 
Artificial Emotion said:
I do it normally when people aren't looking. How do I get rid of this bizarre habit? I can't stop myself. Stimulants make me to it CONSTANTLY, even when people aren't looking. I also eat the stubble. I know this sounds rediculous but I assure you I'm being honest. At least I don't pick my nose and eat it.
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This is grooming behaviour - like a previous poster said, it can be observed to increase in rats exposed to stimulants as well.

In people, it often manifests itself as a "nervous" trait - the girl who spins her hair constantly, nail biting, picking scabs (hello meth heads), etc. All will increase under the influence of stimulants.

I'm sure it's annoying - but it doesn't mean you're insane. Easiest way to "cure" this type of habit is classical conditioning. A clear nail polish that tastes bad is used for children who bite nails excessively, for instance.

I don't know what you should do - hire someone to fire an air horn every time you do it? Sorry.
 
Artificial Emotion,
This is actually a symptom of impulse control disorder and it's called trichotilloma which is the uncontrollable urge to pull out ones body hair, and very often eat it. 25% of the people who do this also suffer from obsessive compulsive disorder. Just out of curiosity, do you ever do this when not under the influence?
If not then it's probably just a result of your excess focus, energy or even your increased anxiety. Lineartransform made a good suggestion with the classical conditioning. The best suggestion I could make as far as that would be to make sure you are freshly shaved before dosing up... or decrease you stimulant use, which is sort of a sucky option.
 
shoolameet said:
Artificial Emotion,
This is actually a symptom of impulse control disorder and it's called trichotilloma which is the uncontrollable urge to pull out ones body hair, and very often eat it. 25% of the people who do this also suffer from obsessive compulsive disorder. Just out of curiosity, do you ever do this when not under the influence?
If not then it's probably just a result of your excess focus, energy or even your increased anxiety. Lineartransform made a good suggestion with the classical conditioning. The best suggestion I could make as far as that would be to make sure you are freshly shaved before dosing up... or decrease you stimulant use, which is sort of a sucky option.
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Wow. According to my psychiatrist I actually have a number of traits of OCD (but not quite the full blown disorder)! How fascinating! I do do this when not under the influence and do it uncontrollably when I'm nervous. I do it so often it's second nature and quite often am not actually aware that I'm doing it. The nail polish idea is pretty cool.

I read somewhere that people who bite their nails live considerably shorter life spans and can suffer from cognitive defecits through ingesting toxins present under dirty fingernails.

After my friend's death I have been put off ingesting psychoactive drugs that do not have a long history of use by man, where the long-term side effects are unknown. Although mephedrone is probably not that harmful t's just too risky IMO.
 
Artificial Emotion said:
Wow. According to my psychiatrist I actually have a number of traits of OCD (but not quite the full blown disorder)! How fascinating! I do do this when not under the influence and do it uncontrollably when I'm nervous. I do it so often it's second nature and quite often am not actually aware that I'm doing it. The nail polish idea is pretty cool.

I read somewhere that people who bite their nails live considerably shorter life spans and can suffer from cognitive defecits through ingesting toxins present under dirty fingernails.

After my friend's death I have been put off ingesting psychoactive drugs that do not have a long history of use by man, where the long-term side effects are unknown. Although mephedrone is probably not that harmful t's just too risky IMO.
Click to expand...

the ocd tendencies tend to be found in those with low serotonin levels, and serotonin is important for control of dopamine based impulses towards rewards in the now so that we can behave in a way to acheive long term goals. serotonin is important for long term strategies, one of my friends used to say that anxiety and impulsivity are the same thing...???
 
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