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  • BDD Moderators: Keif’ Richards | negrogesic

Dysphoric Drugs

dulcie harris

dulcie harris

Bluelighter
Joined
Mar 1, 2009
Messages
65
Location
New Jersey
Are there any drugs that cause a strong sense of dysphoria?
If so, would withdrawl from such a drug cause euphoric effects?
 
lol what?

One thing that pops in my mind is the drugs of delerium. aka. Datura, nightshade, diphenhydramine..etc.

and no youll still feel like shit afterwards

But if your taking about bad trips blossoming into a eye opening revelation..That goes to mushrooms for me
 
Kappa Agonists (Salvinorin A, Butorphanol, Pentazocine etc.) and some Sigma Agonists cause dysphoria.
I doubt that you'd experience euphoria from withdrawal though.
There's no doubt more receptor [ant]agonists that cause such an effect.
Mystery Brew- Ah yes, I forgot about the Deliriants :)
 
monstanoodle got it. Kappa agonists are some of the most common offenders.

Cyclazocine seems to serve no other purpose than dysphoria.
 
Psychedelics CAN be distinctly dysphoric, they aren't neccessarily so but they all have the potential to be. I don't think withdrawal would ever be euphoric no matter what the offending substance(s) were LMAO.
 
Maybe in the last few days of withdrawal, possibly. Purely due to the "thank fuck for that!" effect =D
 
Antipsychotics (Risperdal, Seroquel, Haldol, etc) can cause dysphoria. Taking them regularly is expensive and dangerous though (they are linked to diabetes and a Parkinson's like syndrome called, I think, Tarkinative Diskenisia, both of which are permanent), and the withdrawal is more likely to cause a lot of anxiety and maybe psychosis than euphoria.
 
Anyone would consider piperzines one? Im not sure what it acts on. But some people like it
 
I'd say they're more Anxiogenic, Piperazines. They act as Serotonin, Noradrenaline and Dopamine reuptake transporters (the last two less so than Serotonin).
But if someone becomes anxious on them this could lead to dysphoria.
I'm one of the fortunate ones who really enjoyed the experience :)
 
Definately kappa agonists like salvorin or pentazocine.

anti-psychotics are probably the worst, especially chlorpromazine.

Anti-cholinergics like atropine, scopolamine, and hyoscamine

Opiate antagonists make you feel horrible.

Phenytoin is pretty bad too i bet.
 
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Any kind of cold/allergy medicine makes me extremely depressed. I'd rather suffer the symtoms than take any of that crap. That's just me, though, and I'm kind of an odd duck!
 
DXM seems to have a comedown thats more like a high.

The trip itself can be dysphoric or euphoric but the next day I always feel refreshed and stimulated. Very nice.
 
But say somebody took say... naloxone, for a few months. Since that would block endorphin activity, would the brain then try to compensate with upregulation? So that tolerance, and withdrawal, would develop in the form of abnormally high endorphin activity?
 
I'm pretty sure naloxone is passed out of your system very quickly, therefore you would have to constantly be injecting yourself with a chemical that makes you feel agony, for the sole purpose of feeling relieved when you stop. It's also probably priced similar to just taking opiates.

If you want some endorphin rushes without opiates going for a long run is probably the way to go, it's surprising how effective this can be. For me some heavy activity can be equivalent to snorting 5-10mg of oxycodone, and if you get hooked then you'll just become really healthy (still working on this part).
 
dulcie harris said:
ohh no i'm not looking to get a buzz with this method lol.
i just mean hypothetically would this happen?
Click to expand...

I assume you mean Naltrexone, as Naloxone, as mentioned, is very short acting. People who take Naltrexone (a strong opioid antagonist that can block opioids up to 3 days after a single oral dose) report unpleasant side effects during the time they are on it (especially people who have received a Vivitrol extended release injection that lasts 30+ days, or the Naltrexone subcutaneous depot pellet injection that lasts 90+ days).

Stop using naltrexone oral and call your doctor at once if you have any of these serious side effects:

blurred vision or eye problems;
fast heartbeat;
mood changes, hallucinations (seeing or hearing things), confusion, thoughts of hurting yourself;
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
ear pain, ringing in your ears;
skin rash or itching; or
wheezing, difficulty breathing.
Less serious side effects may include:

feeling anxious, nervous, restless, or irritable;
feeling light-headed, fainting;
increased thirst;
muscle or joint aches;
weakness or tiredness;
sleep problems (insomnia); or
decreased sex drive, impotence, or difficulty having an orgasm.
This is not a complete list of side effects and others may occur. Tell your doctor about any side effect that seems unusual or that is especially bothersome.
Click to expand...

http://health.yahoo.com/addiction-medications/naltrexone-oral/healthwise--d01406a1.html

It doesn't matter which antagonist is taken everyday (Nalorphine, Naloxone, Naltrexone, Nalmefene), the brain does not increase endogenous opioid peptide/endorphin/enkephalin production: as long as the antagonist is attached and outcompeting for the receptors, there is no way for the endogenous opioids to do their thing. A lot of side effects are derived from this inability for the natural opioid system to function properly (and it is attached to a host of body functions and emotions).

When antagonist therapy is withdrawn after several months, the person is very sensitive to opioid agonists. Fatal overdoses following antagonist therapy are fairly common.
 
Tchort said:
It doesn't matter which antagonist is taken everyday (Nalorphine, Naloxone, Naltrexone, Nalmefene), the brain does not increase endogenous opioid peptide/endorphin/enkephalin production: as long as the antagonist is attached and outcompeting for the receptors, there is no way for the endogenous opioids to do their thing. A lot of side effects are derived from this inability for the natural opioid system to function properly (and it is attached to a host of body functions and emotions).

When antagonist therapy is withdrawn after several months, the person is very sensitive to opioid agonists. Fatal overdoses following antagonist therapy are fairly common.
Click to expand...

Im still puzzled. Why wouldn't the brain increase endogenous opioid production if there is an antagonist taking it's place? Shouldnt the brain fight for a balance? Even if it's almost impossible I'd think the brain would still try to counteract the antagonists.

"When antagonist therapy is withdrawn after several months, the person is very sensitive to opioid agonists." Is this basically what the OP is asking about?
If this is true then would the person after quitting antagonist therapy receive much greater effects from his own endogenous opioids?
For example if said person goes running after all antagonists have left his body, would he actually get high on his own opioids? Basically producing an ultra "runners high".

Sorry for all the questions. Your the best Tchort
 
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