Dysphoric Drugs

[rangrz]

interferon sounds fairly dysphoric.

 

[SWIM1809]

From my experience, chlorpromazine is extremely dysphoric.

 

['medicine cabinet']

Trazadone, seraquel and on the top of the list, a large injection of promethazine.

 

[Lady Codone]

Opiate antagonists cause the opposite effect of opiates: dysphoria, depression, and a feeling of hopelessness. Also toxic or dysphoric are the following:

Sinicuichi
Mescal beans
DPTP
Cestrum
BZ/Ditran
PMA
Henbane/Datura/Mandrake

I find Benadryl (diphenhydramine) to be EXTREMELY dysphoric, leaving me in a fatigued depression for days after taking even one pill. Alcohol almost always makes me feel crappy regardless of the type or how much I drink. I get a feeling of a "swollen brain" and get very irritated/angry. Probably an allergic reaction, as I'm allergic to brewer's yeast. Everybody has their own opinions on what's dysphoric vs. euphoric vs. useless.

 

[Tchort]

Im still puzzled. Why wouldn't the brain increase endogenous opioid production if there is an antagonist taking it's place? Shouldnt the brain fight for a balance? Even if it's almost impossible I'd think the brain would still try to counteract the antagonists.

"When antagonist therapy is withdrawn after several months, the person is very sensitive to opioid agonists." Is this basically what the OP is asking about?
If this is true then would the person after quitting antagonist therapy receive much greater effects from his own endogenous opioids?
For example if said person goes running after all antagonists have left his body, would he actually get high on his own opioids? Basically producing an ultra "runners high".

Sorry for all the questions. Your the best Tchort

I'm really not sure. On the one hand, the medical establishment says that long term abuse and addiction/dependancy on exogenous opioids (i.e. external opioids, Heroin, Oxycodone, etc) damages the bodies internal endogenous opioid system (receptors, peptides, enkephalin, endorphin, etc)

Some members of the medical establishment propose that antagonist therapy with Naltrexone for several months or longer somehow 'repairs' or 'speeds up' the bodies natural repair of its endogenous (internal) opioid system.

However, to me this doesn't seem correct. The body has its own series of balances regarding the endogenous opioid system (example: Endorphin vs Dynorphin). It seems to me that both exogenous Agonists (Heroin, Oxycodone) and Antagonists (Naltrexone, Nalmefene), if continued for long periods of time, would both do damage to the natural opioid system.

In both cases, the bodies natural opiates cannot properly function due to being outcompeted by either agonists or antagonists, and with agonists, the withdrawal syndrome really sends the body into hell overall, and in the case of the antagonists, after you stop using them the natural opiate system seems 'raw' and highly succeptible to overdose.

If their claims about antagonists being good for the opiate system were true, you would think that post-Vivitrol or post-ReVia patients would be feeling better than ever, as we do know that endorphin and other natural opiates are responsible for a whole range of responses in the human body (like runners high). But the opposite seems to be true. Patient reports during and for awhile after antagonist therapy seem to suggest that the opiate system of the body is injured worse than during agonist addiction and abuse. Depression, anxiety, PAWS, and a number of other symptoms seem more severe in antagonist patients than in agonist dependants who undergo cold turkey withdrawal. If antagonists really did repair, or help repair the opiate system of the body, why is there such a horrible reaction to them during and well after therapy? Why doesn't the endogenous opioid system perform at least as well as it did pre-addiction?

Unfortunately, the scientific and medical communities do not know very much about the bodies natural opiate system. It wasn't until very recently that they even believed there were opioid receptors.

My guess is that antagonists do as much if not more damage to the opioid system than agonists than the science and medical professionals currently believe. But thats nothing more than a guess.

 

[Tsukasa]

Opiate antagonists cause the opposite effect of opiates: dysphoria, depression, and a feeling of hopelessness. Also toxic or dysphoric are the following:

Sinicuichi
Mescal beans
DPTP
Cestrum
BZ/Ditran
PMA
Henbane/Datura/Mandrake

I find Benadryl (diphenhydramine) to be EXTREMELY dysphoric, leaving me in a fatigued depression for days after taking even one pill. Alcohol almost always makes me feel crappy regardless of the type or how much I drink. I get a feeling of a "swollen brain" and get very irritated/angry. Probably an allergic reaction, as I'm allergic to brewer's yeast. Everybody has their own opinions on what's dysphoric vs. euphoric vs. useless.

I don't find sinicuichi to be dysphoric. I got some pretty nice weed-like trippy euphoria after smoking a home-made sinicuichi resin extract. Most erowid reports for it are positive.