I took a high dose of 2C-E just this last weekend, and I was definitely impressed, actually, blown away would be a more descriptive term. I have a rather hard head, probably from a decade of abusing hard drugs, as well as long term psychiatric medication, and only got a low level response from 25 mg, so I doubled the dose after an hour.
I immediately began to feel like I should have just waited a bit longer, and at one point started to feel like it was going to be to much for my poor fried brain to handle, but I managed to talk myself through the rough parts and was richly rewarded.
For the first hour of my peak, I had intense visuals of Mayan/Incan/Aztec type iconography. I lay in my bed, starting at the ceiling, watching a dragon writhing across the ceiling, smoke spewing out of its nostrils. Then, a corner of my room began to be inhabited by a whirlwind of lights and smoke, an entity inside trying to make contact. At first I felt a foreboding presence, but then realized that the reason it gave me this negative emotion was because I was trying to fight the psychedelic "process". With that knowledge in mind, I felt freed to just enjoy the experience and see what I could learn.
I am mostly interested in psychedelics at this point in my life as a psychotherapeutic tool, and I found 2C-E to be extremely useful in this regard. It definitely did not produce any of the euphoric or empathogenic responses in me that psilocybin or psilacetin did, which was neither good nor bad, it just was. This was the first phenethylamine hallucinogen I have ever taken, and I was not disappointed. It was for sure a different head space than any of the tryptamines I have taken, but again, that is not good nor bad, just different.
As others have stated, this is not "beginners" material, nor is it something to be taken overly lightly as it is a very powerful substance, but it is one I am glad to have experienced, and one that I will still more in the future. I just hope that it remains non-scheduled in my home country (Canada) in the future, although I have heard rumblings about scheduling many of the RC's