I've said this a hundred times, but I guess I'll say it once more: BA % NUMBERS MEAN NOTHING.
Choosing the best ROA depends on a plethora of factors, including the amount of powder being insufflated (the biggest factor), your individual metabolism, and personal preference.
Published BA numbers are complete nonsense, and anyone who blindly buys into them needs to go to college and take a few statistics classes. For starters, snorting 10mg of powder is HUGELY different that snorting 100mg of powder. If you snort 10mg, likely all 10mg will be absorbed intranasally. But if you snort 100mg, about 90% will be absorbed by your lungs and GI, as your sinuses pack fairly quickly with powder.
And just a few figures from my own measurements:
- An OC80 weighs 270mg
- An adderall 10mg IR weighs 240mg
- An adderall 30mg XR weighs 235mg
So basically, if you snort a whole pill of any pharm, it's going to be a MOUNTAIN of powder, and almost none of it will be absorbed intranasally. Most of it ends up in your stomach. So that alone shows how the great "Oral vs. Nasal BA absorption" statistical figures are bullshit.
The second important factor is based on an individual's specific hepatic function. Perhaps they have high 3Ax function which creates noroxycodone and low 2D6 function which creates oxymorphone. Or vice versa. What I'm getting at is maybe the 1st pass metabolism is a good thing, because it produces higher levels of oxymorphone. Conversely, it could create other less desirable metabolites. So you can snort or eat your drug, depending on if the 1st pass metabolism is a beneficial or detrimental phenomenon.
Lastly, different MOAs are a matter of preference. Some people have needle fetishes, some have smoking fetishes, snorting fetishes, plugging, etc. etc. That makes a HUGE difference on the pleasure induced by consuming drugs. Just look at the "crack epidemic" of the '80s; people started turning the water soluble, highly absorbent cocaine HCL into a non-absorbent freebase, SIMPLY because the act of smoking is so much more enjoyable. The onset is slightly quicker, and the smoking aspect is enjoyable, therefore we had an explosion of people smoking crack, despite the fact that it is FAR less efficient than snorting cocaine (as much of the crack is destroyed by heat during the smoking process).
And one more thing, published BA percentages are based solely on measured blood serum levels after long time intervals, which ignores the fact that snorting produces much higher levels much sooner vs. oral consumption.
CLIFFS:
1. Bioavailability numbers mean nothing
2. Figure out for yourself what your own body prefers
3. Snorting bypasses the 1st pass metabolic response
4. Snorting creates a higher high for a shorter duration. No surprise there
5. When you snort oxy, MOST of it goes into your stomach anyway, so it's almost the same as eating it. It's just that you've also got some in your sinuses that will kick in sooner.
Empiricism >>>>>>>> random published bullshit