Here is a good chunk of information that I previously posted in a smaller thread but that I believe belongs here, appropriately in the OpanaER - Mega Thread -

I believe it will be a good (harm reduction) reference to the following topics covered :
(1) make sure your snorting technique is good, so you don't waste anything, (2) try the high-fat meal ordeal, and/or (3) use some sort of CYP450 inhibitor. Of all those, #1 is definitely the most important. Hopefully somebody with a lot of tried and tested experience can chime in with something more specific for you.
(1.1) I have had oxymorphone daily for quite some time in the form of OpanaER and OpanaIR tablets, OpanaER is much superior in my opinion especially for insuffulating for the simple reason OpanaIR tablets are only made in 5mg and 10mg pills, and they are bigger, about 1.5x as much powder as any OpanaER tablet, which go up to 40mg...So when you have a nice high dosage OpanaER Tablet that's the way to go. Say you have a 40mg OpanaER tablet for instance, your snorting ~6x less powder even if you had the highest OpanaIR tablets available (10mg) and ~12x less if you have the 5mg OpanaIR tabs

So when acquiring oxymorphone for insuffulation, OpanaER is the way to go if you get the half of the upper portion of the dosages available, which is the majority.
(1.2)When insuffulating OpanaER, since it is a time release pill it does gel to an extent, but not very badly, its actually something I really enjoy as well as many other Opana users I know and have talked to here on BL.
The reason is this: When you insuffulate OpanaER as opposed to Oxycontin, it has the ability to gels slightly which allows it to stay up in your nasal membranes for a very long time (it can stay up in your noses for hours if you desire (i have), you can control how long you would like to hold you dose up in your nose for the most part, and then swallow it down when you feel like it) and gives it a GREAT chance to absorb, it makes for a very strong and lengthy high, as opposed to Oxycontin dripping down your throat constantly
Don't get me wrong I like my Oxycontin, but after having Opana available it's no contest in my opinion, the fine powder that the Opana tablet creates sticks in the nasal membranes so perfectly, it makes for a far superior high than any Oxycontin high
(1.3 When preparing your OpanaER tablet for insuffulation, DO NOT wipe it off with water, or put it in your mouth like Oxycontin to remove the coating. This makes the pill gel slightly most of the time and your powder is all wet as a result. The powder in Opana is less dence then in an Oxycontin, so that's a factor.
(1.4)To remove the outer film of your OpanaER tablet simply grab a nice handy sharp knife, a nice razor blade, or even scissors have worked pretty damn good for me in a pinch

Then you just grab your OpanaER tablet that now has have its film coating carefully shaved off

I think everyone knows what to do after that:D
(2) A fatty meal a half hour before you dose, or even with your dose when I don't want to wait is always great, whether I'm taking it in the ER form for pain, or IR for insuffalation. I almost always try to eat some kind of food (preferably with a portion of healthy fat

) , it helps everytime and has been documented to raise the BA up to 50%
(3) I don't know much about CYP450 inhibitors yet unfortunately and don't have access to sourced information on the subject yet,
do you by chance happen to have a chart available JC? and/or possibly know of any common ones?
Have fun, be safe, if you have any other questions I'll be around as always
-TheMatador