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treating dopamine deficiencies

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uacvax

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Are there any novel treatments on the horizon for people with dopamine deficiencies, such as ADD? Stimulants no longer work for me and I feel fucking useless without that extra injection of energy and motivation.
 
^ dude i want more research done into possible dopamine deficancy casuing depression. but like right now ssri's have monopolized the market and until people stop taking them i doubt companies will put much effort into reseacrch on dopamine as it seems currently serotonin is working for them as a marketing gig.
 
mr.dopeman said:
^ dude i want more research done into possible dopamine deficancy casuing depression. but like right now ssri's have monopolized the market and until people stop taking them i doubt companies will put much effort into reseacrch on dopamine as it seems currently serotonin is working for them as a marketing gig.
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Nonsense. Take a look at whats in various pharmaco's pipeline for depression. Triple RIs are very big right now.
 
dunno why but for me tramadol seems to have an anti add effect on me. i'm still hyper but i can concentrate well. i use it as an antidepressant once in the morning every day 150mg per day.

works better than citalopram and rids me of paranoia and anger which were both giving me an ugly disposition

how about taking tyrosine supplents? (cheese is a great source of tyrosine)
 
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There are dopamine agonists on the market right now. I take Mirapex for RLS which is a dopamine agonist.

I definitely have noticed an improvement in mood since starting it. That could well be the result of getting better sleep though. However, I am currently doing a 7 day suboxone taper off hydromorphone and H and my mood isn't as bad as it usually gets when I do this.
 
Nicotine is best sensitizes the dopamine system, releases dopamine and acetylcholine. Its also an maoi. Im chewing nicotine gum right now. It can be bought in patches, gum, cigs, pipe tobbacco, snuffs and cigars

The more strong stimulants you use the less dopamine you will have. Some are ok just stay away from things like amphetamines and coke that release ridiculously large amounts of dopamine.

Dont take just one amino acid like tyrosine because it will cause a decrease in other neurotransmitters.

If you have add caffeine will only make it worse. Caffeine sensitivity and add are indistinguishable.

Some of these require a prescription (even these can be bought online), and some can be bought online.

Pramipexole

Ritalin

Ropinirole

bromocriptine

cabergoline

apomorphine

rotigotine

wellbutrin

pergolide

lisuride

apomorphine

Dihydrexidine

Dihydroergocryptine

Piribedil

Propylnorapomorphine

A-412,997

Quinpirole

Rotigotine

SKF 82958

Selegiline

Rasagiline

Budipine

bromocriptine mesylate

Ethylphenidate

MDPV

BZP can be bought very easily for very cheap online

MBZP

2C-B-BZP

Pemoline

Prolintane

Pyrovalerone

Sibutramine

Nomifensine maleate

Vanoxerine

and more
 
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I don't think that nicotine is an MAOI rather the beta-carbolines in tobacco are. Gum won't substitute for ruining your lungs, I'm afraid
 
the thing about caffeine and adhd is that it improves the attention capacity of the person but increases pretty much every other syptom. its a bitch but you have to concentrate at work and before tea i just could not.
 
From my research, here are ways to increase and maintain healthy dopamine levels:

Diet: high in protein (milk, beans, eggs, cheese, etc), and low in carbs except maybe fiber. sweet foods may release dopamine, but use honey, aspartame, or sucralose as sweeteners.
Amino acids - L-tyrosine, L-phenylalanine, L-arginine
Vitamins - C (no more than 5-10 grams), B6, folate, thiamine, and inositol
Minerals - Magnesium, Manganese
other - camillia sinensis (tea), COQ-10, Gingko biloba, SAMe,
Activities/excercises - Meditation, porn/sex/masturbation,
Therapies - Aromatherapy using awakening scents such as mint or jasmine.
Neurochemistry - higher levels of endorphins, acetylcholine, phenylethylamine, cortisol and orexin, and/or low levels of prolactin and GABA would support high dopamine levels. 5-HT2A stimulation (common target of many psychedelics) is know to cause dopamine release.
 
Deprynel, at low doses, has been researched recently, and for depression as well. I'm going to try it soon and see.

Uacvax, most peeps with ADD/ADHD don't NEED an injection of "extra" energy, lol! Stimulants usually calm down excess energy. Motivation, on the other hand, may generate extra energy or at least the will to use it!

As someone mentioned, tyrosine can help build dopamine stores, naturally.
 
As someone mentioned, tyrosine can help build dopamine stores, naturally.
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How exactly does it do that? It's destroyed by MAO pretty rapidly. Doses as low as 5mg may bring on a hypertensive crisis in those with MAO-A inhibited. Considering that, since those not on MAOIs are able to eat grams of it without a problem, I seriously doubt it's doing anything.
 
betsym said:
Deprynel, at low doses, has been researched recently, and for depression as well. I'm going to try it soon and see.

Uacvax, most peeps with ADD/ADHD don't NEED an injection of "extra" energy, lol! Stimulants usually calm down excess energy. Motivation, on the other hand, may generate extra energy or at least the will to use it!

As someone mentioned, tyrosine can help build dopamine stores, naturally.
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I think I'm on the opposite spectrum as you, an inattentive type here, I definitely need the energy. I can only describe my behavior as 'dopamine deficient' , my drive is just shitty.
 
Yes, ADD with the "H" missing IS missing the energy component. RDS-Reward Deficiency Syndrome involves low dopamine I do believe because it seems there isn't much that can activate the Reward System in the brain with dopamine levels less than optimal. If everything just seems "blah" and you don't seem to get any pleasure out of anything, maybe you should see if you have RDS.
 
LOL 'reward deficiency syndrome'

what will be invented next.

It's called depression.
 
I didn't invent the term and apparently docs and researchers consider it a SEPARATE thing..or they wouldn't have named it, lol...ya think? of course all those docs, scientists, and researchers could all just be a bunch of quacks...if so, I married one, LOL!!
 
pofacedhoe said:
dunno why but for me tramadol seems to have an anti add effect on me. i'm still hyper but i can concentrate well. i use it as an antidepressant once in the morning every day 150mg per day.

works better than citalopram and rids me of paranoia and anger which were both giving me an ugly disposition

how about taking tyrosine supplents? (cheese is a great source of tyrosine)
Click to expand...

Tramadol (Ultram) just gives me a mild opiate high along with the feeling of being plastic.

Citalopram (Celexa) was my first SSRI and it worked pretty well for a year.

I don't think tyrosine needs to be supplemented (unless you have a pretty shitty diet); you get tons of it already from various foods. I thought all tyrosine did was help make melanin, levadopa and thyroid-related chemicals anyway?
 
edarrin said:
There are dopamine agonists on the market right now. I take Mirapex for RLS which is a dopamine agonist.

I definitely have noticed an improvement in mood since starting it. That could well be the result of getting better sleep though. However, I am currently doing a 7 day suboxone taper off hydromorphone and H and my mood isn't as bad as it usually gets when I do this.
Click to expand...

I used to take mirapex too. I actually started taking it shortly before they advertised it as a fix for restless leg syndrome because I heard about its dopamine agonist properties - indeed, my insurance company made my doctor co-sign for it because the only people that were taking it at the time were Parkinson's sufferers. I have no idea how I talked my doc into that, but I did (I think I was telling him I was prescribed it previously for sleeping issues; it's very sedating at first). My sleep improved a lot while I was on it, and I wondered why it wasn't being used for RLS...probably because the drug companies didn't feel a need to advertise it as such until they realized they were halfway through their exclusive patent and needed to maximize profit from it. Never noticed anything from it other than the sleep, though; couldn't take it during the daytime due to the sedating properties and it didn't seem to smooth out the effects any drugs I was taking that used dopamine (i.e. cocaine).

The RLS returned as soon as I stopped using mirapex after a year. It's partly the reason I haven't taken SSRIs for a few months now; antidepressants make it ten times worse.
 
here by the way, hammilton, does every reply you make have to have that cheeky snobby tone?

You talk a lot of sense most of the time but ruin it by the way you say things
 
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