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Recreational Potential of MAOIs

Hammilton

Hammilton

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Sep 2, 2008
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I'm wondering if anyone here is familiar with research looking at the recreational potential of MAOIs. Particularly, I'm thinking of (-)-Deprenyl, Phenelzine and Tranylcypromine, the various PEA and Amphetamine analogues.

I'm aware of a few real studies on (+)-deprenyl, which seems to be equal to amphetamine, but gives no abuse potential for (-)-deprenyl, and a few case studies on Tranylcypromine, but nothing properly done.

this seems to suggest minor abuse potential for (-)-deprenyl.
http://www.sciencedirect.com/scienc...serid=10&md5=6b232debe72775996d926d99592c36be
 
I don't know that "moclobemide + DMT" is really what I mean. I'm looking for research, and on that subject, I see little or nothing.
 
Just to note: Moclobemide is one I'm specifically not interested in. I'm intereste in the DARI effects of the PEA derived MAOIs.
 
^^^ I've taken a 100 mg dose of tranylcypromine. It was sedating in a feverish weird way with some hallucinogen-esque body feelings and sensations. My mind was definitely in a very different space, but I wouldn't say I enjoyed it in any way. It was neutral, perhaps slightly negative. I dunno. I took it or a week or so, I think, at 10-20 mg and never really noticed it. Certainly didn't make me any happier.
 
Interesting, but not quite what I'm looking for. The case reports I find make it seem stimulating. Shulgin barely touched tranylcypromine derivatives; I think only one?
 
^^^ That's why I tried it. Case reports listed it as being about 1/10th as potent as dextroamphetamine as a stimulant. It was nothing like dextroamphetamine *at all*. Not stimulating, just weird.
 
Again, that's exactly what I don't care about.

Yes, AFAIK, that's the only tranylcypromine analogue tested.
 
edit: apology accepted, good excuse, I admit. I can't stand the taste that stuff leaves in my mouth though; God forbid you actually have it on your tongue, it never seems to go away. I always wondered if the taste it produces is from the molecules getting to taste buds through the blood stream. I bet it's something humans can taste in the ppm range. I know we can smell things that low, but never saw anything about tasting. Anyway, now we're really off topic.

Mellow, you should stick to smoking methadone...
 
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Okay buttface, here's what I got for you:

One:
J. Tuomisto1, 3 and D. F. Smith2
Effects of tranylcypromine enantiomers on monoamine uptake and release and imipramine binding
http://www.springerlink.com/content/x5p3019g2l370461/

Two:
AS Villégier, S Lotfipour, SC McQuown "Tranylcypromine enhancement of nicotine self-administration" in Neurpharmacology 2007
It enhances nicotine consumption in rats by like 6-9 times.

Oh, and... it releases NE:
JOSEPH J. SCHILDKRAUT M.D.1 "Tranylcypromine: Effects on Norepinephrine Metabolism in Rat Brain " Am J Psychiatry, January 1970


If you want any of these articles I think I can grab 'em. And you can go suck an egg if this isn't what you're interested in. ;)
 
those first two are exactly what I'm looking for, especially that first one. It seems a little worrying that it might increase nicotine (I assuming it makes it more enjoyable?) that much, that's gotta be getting close to seriously dangerous doses.
 
A lot of people have made little guesses as to how it works, mechanistically, re: the nicotine. So if you do a Google Scholar search around "tranylcypromine nicotine" you'll see a lot of speculations and the original article. I may have access to it, so send me a message if you want 'em, 'kay?
 
Has anybody tried moclobemide who actually liked it?

Just the fact it is even on the market must mean it has passed a crap load of clinical trials.

I'm interested in trying new things out and this was somewhere down on the list of options.
 
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