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Methysergide- Use with CAUTION

B

B-Side

Greenlighter
Joined
Aug 6, 2008
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25
Me and the missus have 10 tablets of Methysergide, each at 1mg. Unortunately I dont beleive this is a suitable amount for tripping, which would start at about 16 mg per person?

So we're probs just gonna use them with MDxx (Preferablyxx=MA, but eh) of some sorts.

Will report on how it goes.

Just wondering, would methysergide be pluggable? Cause then, we might be coming close to LSD trip standard levels...

Ta.
 
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So we're probs just gonna use them with MDxx.
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Not a good idea--the interaction effects of methysergide and MDMA are in no way known and might be unpleasant. Methysergide does have affinity for the 5-HT2A receptor, but it has such a low efficacy as an agonist (less than 10% of the effect of 5-HT) that it is unlikely to elicit the same type of effects as LSD or other more active ergoloids. Some people might get effects, other people definitely won't. The fact that methysergide has affinity for all sorts of other receptors might cause a lot of side effects.
 
Is there any actual report on methysergide on the internet? Or has anyone heard or read a report somewhere and could share it?

If 4mg is equipotent to 25mcg of LSD I wonder why it doesn't seem to be popular anywhere. It wouldn't be very hard for me to buy some here, it's not a heavily controlled substance.

To the original poster I would rather suggest mixing it with weed, as it certainly potentiates low doses of LSD a lot.. MDMA will probably be overpowering, if not dangerous as already mentioned.
 
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I wouldn't mess with this stuff. Especially after taking 3mg sublingual Hydergine today and nearly passing out, sweating bullets, vision whiting out, and then just chilling with a heart rate of around 50bpm all day. I know its not the same thing but sounds close enough to me.
 
^^ Really? I've never had any particularly troubling side effects with hydergine, even at doses of up to 22.5 mg in a day. Individual sensitivity in response is an amazing phenomenon.
 
How strange that this makes you trip and people don't really do it. Must have some bad effects...

Then again people still do Dramamine. lol
 
Okay, sorry bout the late reply!

I am I(medium tolerance to most things), the missus is k (extreme lightweight)

t+0.00-.30 : I: half a bottle of baileys/ half a botle of schnapps over 30
k: 2 cruisers (that gets her pretty tipsy)

t+ 2..00-2.30: Few cocktails, 2 each.

t+3.30-4.00: me,k and a friend buy a 700ml bottle of baileys. i'd say I had half, k had a quarter and the other quarter went to the friend(only drinking)

* WARNING: QUITE POSSIBLY THE WORST COMBINATION EVER, DO NOT TRY*

t+5.30: KFC. disgusting. SO bad. fatty,greasy chicken,popcorn chicken, and chips and BLEUGHRRHRHGUHOQKLNFA Disgusting.

t+6.15: I, and k both had 5- 1mg tablets of methysergide ( also very stupid of us. prescription + alcohol. Stupid. But then again, is that bad considering LSD was used to help treat alcoholics?(or something like that))
then proceed on a train trip homewards, where k throws up about4-5 times, and I'm alright as long as I dont look at her. K reports she did she a few little chiunk s of what looked like tablets.

t+8.30: after a train and car ride home( we werent driving) we get home and go to bed. We were extremely sleepy, K fell asleep in the car, or napped./ wasnt deep just like.. you know what I mean. Very Light sleep.

We lie in bed for ages, contemplating sex, but decide it would end up rolling around in spew.

t+9.30we lie there for about an hour. Awake as anything. Mind is working so fast it wqould be impossible to sleep. BUt there is a little body load.

t.+10.00another half hour passes, and things slowly start moving. just the usual. it looks like the rooms moving(breathing) a bit. some patterns moving in the carpet, not a whole lot. STill wide awake. No crazy thought processes yet.t+13.00. I start trying to trip k out. That is how I normally spend most of my trip, trying to trip people out but in the process making me belive myself aswell. The next 4 hours is spent ccontemplating, feeling things (i.e: each other:P) and me making weird conversation about crazy theories.(as per usual, its just more beleiveable to others now)

t.17.00. starting to really feel more like acid now. where you close your eyes, then open then and you womnder where the fuck you are. I really start rambling crazy now.

t+18.30: we each take a 5mg valium tablet and pass ut for about 6 hours in the most blissful sleep ever with some odd dreams. Couldnt remember a thing about them ceopt they was weird.

In conclusion. Having only 5 tablets each, or 25 ug of LSd, it does resemble acid, and with a higher quantity, it would rather much be like acid, except that it takes alot longer to kick in, but It still does drag on.
I think if taken earlier in the day, without kfc and alcohol it would be rather enjoyable, as It keeps you ALOT more mentally alert and I think it would be less bodyload than normal acid



As for why people dont use it as much. normal acid is probably easier to get than this. this is a prescription for igraines caused form mesntrual pains. SO, only women can get it, and its prescription only. Go figure.


Done.
 
I believe that any psychedelic activity this compound might possess would have to be due to the metabolite methylergometrine (N-[(hydroxymethyl)-propyl]-lysergamide), as the parent compound methysergide is a 1-methyl-ergoloid and those are usually such low-efficacy 5-HT2A partial agonists that they can be considered to be antagonists for all practical purposes.

Methylergometrine, on the other hand, has to be similar to ergometrine in action and ergometrine is a full-blooded active psychedelic ergoloid (and quite an enjoyable one, I might add...although it still doesn't match LSD's almost complete lack of peripheral side effects).
 
morninggloryseed said:
Sansert is not just prescribed for headaches associated with menstrual pain. BS.
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Sansert? Who said this was sansert. I cant remember what it was, but its not sansert, otherwise I would have recognised the name straight away.

Do we have sansert in australia?
 
Riemann Zeta said:
I believe that any psychedelic activity this compound might possess would have to be due to the metabolite methylergometrine (N-[(hydroxymethyl)-propyl]-lysergamide), as the parent compound methysergide is a 1-methyl-ergoloid and those are usually such low-efficacy 5-HT2A partial agonists that they can be considered to be antagonists for all practical purposes.

Methylergometrine, on the other hand, has to be similar to ergometrine in action and ergometrine is a full-blooded active psychedelic ergoloid (and quite an enjoyable one, I might add...although it still doesn't match LSD's almost complete lack of peripheral side effects).
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agreed.

Wiley Science Journal said:
Analysis of canine plasma by high-performance liquid chromatography showed that after both oral and intravenous administration of METHYSERGIDE large amounts of METHYLERGOMETRINE appeared in the plasma. Whereas only low and transient levels of METHYSERGIDE could be detected. It is suggested that one of the first steps in metabolism of METHYSERGIDE is demethylation at position 1 of the indole, leading to the formation of METHYLERGOMETRINE, which may be a main active principle of the therapeutic effectiveness of METHYSERGIDE in the interval treatment of migraine headache.
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Methylergometrine is more commonly known by the name "methylergonovine"

TiHKAL has some light to shed on this molecule;

TiHKAL said:
Ergonovine is a naturally occurring, water-soluble ergot alkaloid, found in both ergot preparations and in many species of morning glory seeds, and there are several reports of LSD-like action at oral levels of between two and ten milligrams. It has an important use in obstetrics, again as an oxytocic, at about a tenth of this dose. This pharmacological potential must be respected in psychopharmacological trials. The one-carbon homologue (the butanolamide rather than the propanolamide) is called methergine or methylergonovine. It is a synthetic ally and is orally effective as an oxytocic at a dosage of 200 micrograms. It also has an LSD-like action at ten times this level.
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WARNING - Methylsergide is known to be a cause of cardiac fribrosis due to it's affinity for the 5HT2b receptor and as such is only licenced for hospital inpatient treatment in the UK.

In other words: Don't, find something else safer to trip with and leave methylsergide for treating what it's prescribed for
 
fastandbulbous said:
WARNING - Methylsergide is known to be a cause of cardiac fribrosis due to it's affinity for the 5HT2b receptor and as such is only licenced for hospital inpatient treatment in the UK.

In other words: Don't, find something else safer to trip with and leave methylsergide for treating what it's prescribed for
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This only happens with long term usage.... it does not happen even using it twice a month. Same thing with fenfluramine or any 5ht2b receptor agonist
 
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