N&PD Moderators: Skorpio
Oxytocin agonists
Doctor Abalaba
Bluelighter
I have a sneaking suspicion one of these would be quite interesting and am having some trouble finding articles on my university's databases. However, I know some articles are out there. Any ideas or help would be great.
hamhurricane
Bluelighter
i would be curious as well, there were several reports out of people snorting/IVing oxytocin proper and getting no/small effect but who knows about its (other) agonists. I have tried desmopressin a few times and i found the effects to be uninteresting, i think these things often get over-hyped.
egor
Bluelighter
Try pubmed if you have not already
Riemann Zeta
Bluelighter
I've also tried desmopressin before and found the same amount of hype, but no worthwhile memory potentiation.
But that's really more of a vasopressin agonist rather than an oxytocin receptor agonist. There are non-peptide oxytocin agonists, check out: Pitt, et al (2004). Non-peptide oxytocin agonists. Bioorg Med Chem Letters. 14: 4585-4589. Obviously, you are never going to find a compound like this commercially available on either normal or grey markets--it would have to be custom synthed.
If you don't mind its pro-oxidant toxic metabolites, MDMA induces the release of oxytocin. Obviously, one should use it as sparingly as possible and take things like acetyl-l-carnitine, alpha-lipoic acid and/or other antioxidants along with it.
El Cubano Poco
Bluelighter
DMT also releases Oxytocin, as well a vasopressin, HGH, and other chemicals me forgets:D
MurphyClox
Bluelighter
A recent review on the topic is this one:
"Nonpeptide oxytocin agonists"
Ashworth
Drugs of the Future 2006, 31(4), p.345
Maybe somebody can get it for you...
- Murphy
MurphyClox
Bluelighter
This pic is from the Bioorg Med Chem Letters-article that Riemann Zeta cited:
Now you got at least an idea about some structures. None of them is commercially available. The ref is again:
Bioorg Med Chem Letters 2004, 14, p.4585
Further reading on oxytocin agonists can be found here:
Drugs of the Future 2002, 27, p.248
J Med Chem 2002, 45, p.3805
Should be easily accessible with an uni-account...
Peace! Murphy
Hammilton
Bluelighter
I dunno about the number, but I don't really get the point.
Pitocin isn't recreational at all...
f13nd
Bluelighter
In the lab I do brain microtomes and behavior analysis for, they inject pregnant rats with pitocin and they give birth to autistic pups. Pitocin causes production of oxytocin...and I don't think its really euphoric. We read studies of people given intranasal sprays of oxytocin and it was shown to increase the likelihood of trusting a stranger, but that really was it...
f13nd
Bluelighter
Oh and I remember my professor saying that alcohols effect on vasopressin can cause oxytocin activity
Jabberwocky
Frumious Bandersnatch
I snorted some oxytocin one time and all it made me do was become somewhat depressed (physically not mentally) and my eyes teared up and I laid down and after about a half hour it was gone.
I noticed nothing therapuetic or whatever in it.
iirc the dose was about 7mg
Limpet_Chicken
Bluelighter
Out of curiosity, how does an autie rat act?
Shame it doesn't work on humans
from what i've read on the internet it sounds like pitocin is a brand name for oxytocin but i could be wrong. As it is a peptide and can't cross the BBB i don't think that injected pitocin would have any effect on mood at all. i am a bit doubtful on how effective bypassing the BBB by nasal administration really is. maybe a real synthetic oxytocin agonist would have more profound psychoactive effects...
anyone up for custom synth and bioassay?
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Hammilton
Bluelighter
Pitocin causes the production of Oxytocin? Really? Does water make water too? Pitocin = Oxytocin just as Dexedrine = d-amphetamine.
Jabberwocky
Frumious Bandersnatch
You don't need a custom synthesis to get ahold of oxytocin. It is active via insufflation.
10mg cost me about 75$ from a biochem supplier (pricey but it was a one-time thing).
Opiates increase vasopressin levels, don't they?
Is that why you were interested in increasing oxytocin levels? Because of the thinking that it might mediate the euphoria associated with opiates and MDMA?
I've had interest in both vasopression and oxytocin for some time now myself, but because of the promise of improved memory and libido, both of which are shot.
All the substances which I've ingested in the hopes of improved libido have backfired, either diminishing libido, or affecting libido in no way but causing significant adverse effects. I am getting desperate here. Unexpectedly, amazingly, and paradoxically, Quetiapine fumarate is the only substance I have used that has improved my libido and it's of course a dopamine antagonist. (I guess it achieves this effect through dopamine receptor up-regulation?) The side-effects are intolerable, though, so I stopped taking it.
/Has anyone ever tried Bremelanotide (PT-141)? http://www.researchpeptides.com/PT-141-Bremelanotide-10mg/Detailed-product-flyer.php
It's supposed to be able to dramatically increase libido and quality of erections. Caution should be taken, though, as it can cause hypertensive crisis.
Oops. I should have been more specific. Mu-opioid receptor agonists stimulate the release of vasopressin, right?
By the way, how did the sophora prostrata affect you psychologically? Did it make you feel depressed? Did it cause you to hallucinate?
