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Selegiline and PEA [and hopefully others]

mitragyna

mitragyna

Bluelighter
Joined
Dec 7, 2006
Messages
242
Lately, I've been looking for the next best thing to D-Amphetamine (I'll be running out of my Amp supply soon). I'm wondering if you guys could help with some ideas for legal alternatives. I'm hoping these agents will give enough energy/motivation to help the withdrawl. Basically, I'm looking for anything to keep my Dopamine levels from hitting rock bottom once I stop the amps. The anxiety should be under control, since I have Lyrica and Gabitril in my supply.

I'm on 12 mg of Selegiline daily, so I thought of the idea of ordering some PEA to take with it. Do you all think that this may be my best option after cessation? Maybe just even raising my dose of Selegiline to 20 mg or so may help...?

Thanks a lot!
 
Adrafinil, Modafinil, Vyvanse, MDPV, Ephedrine, Mephedrone..
 
Except, the majority of those would be really, really, dangerous to take with seligiline.
 
Can one develop a tolerance to PEA?

One more question: Is it really possible to develop a tolerance to PEA? I've heard many conflicting opinions, especially here at Bluelight (many folks have said they developed a tolerance). This following abstract says that PEA is not tolerance forming:
Sustained antidepressant
effect of PEA replacement
by
Sabelli H; Fink P; Fawcett J; Tom C
Rush University and the Center for
Creative Development, Chicago, Illinois, USA.
J Neuropsychiatry Clin Neurosci, 1996 Spr, 8:2, 168-71


ABSTRACT

Phenylethylamine (PEA), an endogenous neuroamine, increases attention and activity in animals and has been shown to relieve depression in 60% of depressed patients. It has been proposed that PEA deficit may be the cause of a common form of depressive illness. Fourteen patients with major depressive episodes that responded to PEA treatment (10-60 mg orally per day, with 10 mg/day selegiline to prevent rapid PEA destruction) were reexamined 20 to 50 weeks later. The antidepressant response had been maintained in 12 patients. Effective dosage did not change with time. There were no apparent side effects. PEA produces sustained relief of depression in a significant number of patients, including some unresponsive to the standard treatments. PEA improves mood as rapidly as amphetamine but does not produce tolerance.
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The original link may be found here.
 
mitragyna said:
Lately, I've been looking for the next best thing to D-Amphetamine (I'll be running out of my Amp supply soon). I'm wondering if you guys could help with some ideas for legal alternatives. I'm hoping these agents will give enough energy/motivation to help the withdrawl. Basically, I'm looking for anything to keep my Dopamine levels from hitting rock bottom once I stop the amps. The anxiety should be under control, since I have Lyrica and Gabitril in my supply.

I'm on 12 mg of Selegiline daily, so I thought of the idea of ordering some PEA to take with it. Do you all think that this may be my best option after cessation? Maybe just even raising my dose of Selegiline to 20 mg or so may help...?

Thanks a lot!
Click to expand...

So you're using dexamphetamine daily and seligiline (12mg) daily as well? That's incredibly bad for you... especially every time you use amphetamine. I'd say you have no chance in hell of having PEA work with selegiline considering you've been combining amphetamine and selegiline. And upping your selegiline is another really bad idea. Seriously, you're combining MAOIs with stimulants, I don't know what you're doing..
Also, you'd get more replies in OD. ADD is more for advanced Qs
 
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I also take amp (adderall XR) and would like to be able to have days off of it so that I can lower tolerance (I don't use it to get high) and was wondering if PEA would have have any effects if combined with amp.

If i were to take an MAOB drug I don't think i'd combine it with the amp, however I don't really have much access to any MAOB drugs anyway. Would Kava make a difference when using PEA? atleast something more noticeable than nothing?
 
selegiline and adderall is not as efficient as selegiline and ritalin. this is because selegiline prevents transporters from being inverted, or so i thought, and one of adderall's big benefits is inverting DA transporters. ritalin and selegiline is a combination i've heard of as being better. particularly the daytrana patch.

combining selegiline and PEA is more psychedelic than selegiline and purely dopaminergic stimulants. it's cooler but to me it became a little weird.

the other stimulants you mentioned arent nearly as good as selegiline. you've basically already found the holy grail of safe stimulants. congrats though!


upping your dose will eventually cause you to get serotonin and norepinephrine effects, which would probably feel nice, but at some point beyond 10-15mg, the relative increase in dopamine becomes less pronounced because -- 1. you reach the ceiling for mao-b inhibition and 2. you start counterbalancing with 5HT and NE. that said, i am looking to up my selegiline dose to 20mg from my current 10, next time i see my doctor. just because i feel like it would be a better antidepressant.
 
djsim said:
So you're using dexamphetamine daily and seligiline (12mg) daily as well? That's incredibly bad for you... especially every time you use amphetamine. I'd say you have no chance in hell of having PEA work with selegiline considering you've been combining amphetamine and selegiline. And upping your selegiline is another really bad idea. Seriously, you're combining MAOIs with stimulants, I don't know what you're doing..
Also, you'd get more replies in OD. ADD is more for advanced Qs
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As a matter of fact, combining Selegiline and dexamphetamine can actually be better for your health than just using dexamphetamine alone. That is, if you keep your dose of the dex very low. Most, if not all neurotoxicity can be prevented from the use of Selegiline along the the dexamphetamine.

So if you would, please elaborate on "that's incredibly bad for you".

P.S. My PEA just arrived and I took my first dose a few hours ago. It worked wonderfully for a couple hours. I will probably take a lower dose though next time, as my blood pressure seems to have risen a bit...much more than it ever did with any amphetamine.
 
I've found selegiline to be a very effective *blunter* of the effects of amphetamines. I don't know of any negative side-effects of the combo from personal experience.

I second Mitragyna's note about the health thing, based on a paper I read about it being effective at reducing d-amp's ability to induce hypertension.
 
mitragyna said:
As a matter of fact, combining Selegiline and dexamphetamine can actually be better for your health than just using dexamphetamine alone. That is, if you keep your dose of the dex very low. Most, if not all neurotoxicity can be prevented from the use of Selegiline along the the dexamphetamine
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Um, great, but you're not using very low doses of dexamphet, so I fail to see how that is relevant. I'm talking about you running selegiline with dexamphetamine, not other hypothetical situations.

So if you would, please elaborate on "that's incredibly bad for you".
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MAOI and sympathomimetic combinations have always been contraindicated, so I fail to see how saying this combination is bad for your health could be news to anyone.

And I'd think upping your dose to 24mg of selegiline would pretty much ensure loss of specificity for MAOI-B, leading to some pretty nasty side effects.
 
If he's not having hypertensive crises, then it's not incredibly bad, is allowing for lower doses than would otherwise be needed and providing the neuroprotective benefits of the selegiline.

It's quite obviously not incredibly bad for him. Used irresponsibly, obviously MAOI+Amps is a really bad idea, however, the risk is immediate not a long term thing, so saying it's incredibly bad is incredibly wrong.
 
I'm very interested in adding Selegiline to my dailys. I take adderall or vyvanse in pretty high dosages... Like at least 40-60mgs dexamp or 70-100 mg vyvanse daily. I want to lower my dosages with selegiline... but because its an MAO-B (I?) inhibitor, im worried about whether I will be able to do DMT or shrooms or things like that if they pop up....
 
selegiline and adderall is not as efficient as selegiline and ritalin. this is because selegiline prevents transporters from being inverted
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However, Doses of selegiline tend to be pretty low (in the range of 5-10 mg / day during induction, lower / less frequent once inhibition of MAO-B has been established, since the inhibitor is irreversible), so we would expect inhibition of transporter inversion to be low (and nigh nonexistent on days when no selegiline was taken).

I dunno: while I found selegiline to potentiate methylphenidate to a greater degree than it does amphetamine, I qualitatively preferred the combo with amphetamine, and found continued potentiation, not attenuation of effects.

So I wrote an FAQ on this issue, but while under the influence of PEA or amphetamine, so sorry about the wordiness. :P

The short take home is that you need to be really fucking careful.

ebola
 
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