I don't disagree, that's what I would say to someone, but like I mentioned, its genetic.
One of my first drug experiences was taking diazepam as a teenager and I had mania and anxiety. Well before I used a lot of drugs or drank.
And the only drug that ever exacerbated the effect was alcohol.
The closest thing I can compare the feeling to is acute alcohol withdrawal, but that's also a poor comparison.
Also, I get the same effect from taking magnesium glycinate. Glycine plays a crucial role in the brain as an agonist of glutamate. Yet for the vast majority of people it has a calming and hypnotic effect. That's also contradictory lol.
For whatever reason, my CNS, under certain but specific conditions, releases glutamate instead of inhibiting it.
I think there is enough here to support my hypothesis that the main mechanism is glutamate overactivation.
Yet in the end nobody knows how or even why it happens. Brains are strange.
Oh I almost forgot to mention that dissociatives including DXM, as well as the medication Acamprosate helps a lot when this happens. Acamprosate normalizes overactive NDMA receptors.