If cocaine blocks reuptake of dopamine..

[Barrett66]

I find it interesting when stimulant users act like opioids are something terrible.
Sure they're addictive & you don't want a dependence on something if you have no constant access to it. That part is understandable, but opioids are less toxic & destructive on your body & brain than stimulants.

Not to mention cocaine is cardiotoxic.
And amphetamine is neurotoxic.

Yet it's the opioids (some of the least toxic drugs there is) that always get the bad rep in the drug world.

I've asked several meth dealers over the past several years if they fucked with heroin & they acted like I asked them if they enjoy killing people.
Like okay, you're literally using/selling a drug that's neurotoxic & turns people into hypersexual sleep deprived zombies, but heroin is a step too far? lol Yeah right. You can usually tell if some one's educated on pharmacology/drugs or not when they act like meth is okay but heroin is some how worse for you? lol

we can thank the Sackler family for this absurd "Opiate Crisis" bullshit. seems like every movie or TV series I see now has some sort of element pushing an agenda against opiates and it's fucking ridiculous. I take them responsibly for chronic back pain and only low dose hydrocodone but I never abuse them or anything else, it pisses me off when they make such a big deal about it but then you watch movies like euphoria and they're doing Coke and acid and all kinds of other shit like Molly and MDMA math you name it and that doesn't become a crisis as far as the government's concerned. They should be looking at the fentanyl as the biggest crisis in the US right now maybe even the world but not just standard opiates like Percocet or hydrocodone etc etc. It truly pisses me off lol

 

[GaumarolBostich]

Methylphenidate (Ritalin) is actually nearly twice as potent as Cocaine at DAT (ED-50) effective dose to inhibit 50% of dopamine transporters DAT which is required to experience euphoric effects

So you are suggesting that Ritalin is an excellent alternative to Cocaine without the cardiovascular threats? What about the serotonergic effects?

Could be a nice mix to 4-MMC then when taken cautiously.

 

[Hexenstahl]

we can thank the Sackler family for this absurd "Opiate Crisis" bullshit. seems like every movie or TV series I see now has some sort of element pushing an agenda against opiates and it's fucking ridiculous. I take them responsibly for chronic back pain and only low dose hydrocodone but I never abuse them or anything else, it pisses me off when they make such a big deal about it but then you watch movies like euphoria and they're doing Coke and acid and all kinds of other shit like Molly and MDMA math you name it and that doesn't become a crisis as far as the government's concerned. They should be looking at the fentanyl as the biggest crisis in the US right now maybe even the world but not just standard opiates like Percocet or hydrocodone etc etc. It truly pisses me off lol

I'm the last one to defend plutocrats, but honestly the Sackler family didn't do anything the other pharmaceutical companies weren't already doing. The Sacklers were just picked as the face of the so called opioid crisis because every good propaganda campaign needs a symbol people can project their feelings on, as the father of the PR-Industry, Edward Bernays, once correctly stated.
As far as the the opioid "crisis" is concerned: it doesn't exist. We have an (intentional) overdose crisis, but no opioid crisis. People should look to the 19th century when drug laws didn't exist at all and every drug was freely available and take a look at the state of society back then. No [insert drug] crisis to be seen. Sure, some people became addicted to heroin, cocaine, opium, etc. but society functioned because these people weren't criminalized. They could pursue careers, have families and just lead overall normal lives despite their addiction, which proves that drugs, no matter how addictive, are NOT the problem. Prohibition with all its effects however IS a problem. Now try to make the stupid sheeple understand that and we'd live in a much better world.
But it has always been easier for the stupid human species to look for an easy scapegoat than to critically reflect on ones opinions. People just like to be herded like the idiotic animals they are.

- Mundus vult decipi, ergo decipiatur -

 

[GaumarolBostich]

I agree with many things you wrote @Hexenstahl but I like to throw in that drug supression is resulting from a fear to loose control which is part of human nature. So drug laws are invented from people who have no or little experience in psychedelic substances except Alcohol of course for people who have the same experience level. What unites them is the fear to loose control for themselves and their beloved. A fear that is not ungrounded in my understanding because there is a certain percentage that slip into addiction in many ways. I don't know what social status a opium user had in the unrestricted times but it is certainly aligned with functioning socially and societywise (work, family etc.).

My personal view is that our brain is built to hunger for rewards, if you focus on single methods to satisfy it (drugs, sex, gambling, sports) and use shortcuts you step on a slippery slope. If you are able to spread your rewards and manage to enjoy long lasting rewards and satisfaction then you do not loose control.