N&PD Moderators: Skorpio
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Smyth2
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3-(1H-indol-3-yl)-N,N-dimethylcyclobutan-1-amine
pubchem.ncbi.nlm.nih.gov
Leads to this triptan:
4991W93
(4S)-4-[[3-[3-(Dimethylamino)cyclobutyl]-1H-indol-5-yl]methyl]-1,3-oxazolidin-2-one
[171549-56-7]
Jandu KS, Barrett V, Brockwell M, Cambridge D, Farrant DR, Foster C, Giles H, Glen RC, Hill AP, Hobbs H, Honey A, Martin GR, Salmon J, Smith D, Woollard P, Selwood DL. Discovery of 4-[3-(trans-3-dimethylaminocyclobutyl)-1H-indol-5-ylmethyl]-(4S)-oxazolidin-2-one (4991W93), a 5HT(1B/1D) receptor partial agonist and a potent inhibitor of electrically induced plasma extravasation. J Med Chem. 2001 Mar 1;44(5):681-93. doi: 10.1021/jm000956k. PMID: 11262079.
Robert Charles Glen, et al. WO1995020588 (to Wellcome Foundation Ltd, SmithKline Beecham Corp).atara
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Rectify
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EROSAPHINE
1-methyl-2-(3,4-methylenedioxyphenyl)-ethyl)-3-carbomethoxy-4-(N,N-dihydroxyphenyl)aminopiperidine
This One Might Actually Help Me Gain Some Royalties.
To Quote The Sugarhill Gang, This One Is My “Devastating Masterpiece” Of The Entactogenic Synthetic Small Molecule Opioids.atara
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Haha, I was going for a short acting NDRI with an easy synth
Yup, That Pretty Much Sums It Up.
Smyth2
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Gálvez G, González-Gutiérrez JP, Hödar-Salazar M, Sotomayor-Zárate R, Quintanilla ME, Quilaqueo ME, Rivera-Meza M, Iturriaga-Vásquez P. UFR2709, an Antagonist of Nicotinic Acetylcholine Receptors, Delays the Acquisition and Reduces Long-Term Ethanol Intake in Alcohol-Preferring UChB Bibulous Rats. Biomedicines. 2022 Jun 22;10(7):1482. doi: 10.3390/biomedicines10071482. PMID: 35884787; PMCID: PMC9312520.