Phenethylamines Vaping/smoking mescaline

[red22]

I've only smoked cactus.. It does work but like Shroomopotomus said it feels like a waste.

It's also very different from oral in terms of energy(or lack thereof), and there are visuals as in you see more clearly and the fov shifts slightly, but no CEVs and none of those amazing mescaline colors.

ShiroiTora, 02/18/25, https://www.shroomery.org/forums/showflat.php/Number/29129999#29129999

Elaboration:

It comes on much faster and feels like a less aggressive form of DMT(only thing I can compare it with) minus the colour depth and things moving.

Like my boi Terence has described DMT, "It immediately feels as if all the air has been sucked out of the room", and this extends into the audio realm with an unforced but noticeable silence filling the usually busy space. Calm clarity without the sense of angst that DMT provides(ok maybe some angst, but definitely a lot less than with deems).

Like previously mentioned the colors are washed out compared to DMT and even oral mescaline itself, but the rest of the visual effects persist; I can see further more clearly with a wider fov(mescaline is the only thing that affects fov strongly for me). The high doesn't feel as strong or full spectrum as with oral ROA and only lasts about 5 hours, with no effects on nausea or depths of thought, kinda feels like 2C-B in that way. Dosage is a bit more than expected, for the amount I smoked I could have had a nice buzz for a solid 8 hours orally. I mean I don't regret it but oral is a much better experience imo..

02/19/25, https://www.shroomery.org/forums/showflat.php/Number/29131090#29131090


DOC, a mescaline relative:

anyone else tried to vap it off foil or glass yet?

I vap'd an unknown amount of crystal between 2-4 mg(scale wasnt accurate to 1mg)

take a blast while i slowly heat and visuals come on instantly with a rush of euphoria

almost makes you wanna fiend for it cuz the rush is so nice and i felt after effects for the next 6 hours but im also very sensitive to stimulants because of my opiate/benzo/ketamine abuse in the past

thevines2, 01/10/12, https://www.bluelight.org/community/threads/the-big-dandy-doc-thread-part-2.599030/post-10237907


Reports of people vaping and smoking psilocybin and psilocin

 

[red22]

Peyote can in fact be ground up into a powder and mixed with tobacco/weed and you can definitely smoke it

agent.h.music, 2025-09-05, Instagram

 

[red22]

"cactus is gentle and I think it's better. you only need some water and you get good to sprinkle. You can sandwich like DMT too. I pear with other herbs and CBD."

free fred, 2025-10-13, https://www.shroomery.org/forums/showflat.php/Number/29372496/


"I’ve heard of people smoking the skins, mostly from peyote."

Soloist, 2025-10-15, https://www.shroomery.org/forums/showflat.php/Number/29373727#29373727

 

[Didgital]

Ive been toying w idea of whipping up some 2c-b and or mescaline vapes. Apparently 2c-B vape carts are a thing. I would guess that a mescaline vape does work, however, i wpuld expect it to taste terrible, potentially be corrosive to mucous membranes, and impotent enough that several tokes would be required.

One would have to convert to the freebase of course.

Certainly not a priority tho.

 

[red22]

But Josie Kinz ages ago posted about how vaping 2C-B is something everyone should try at least once.

 

[xdrc]

Ive been toying w idea of whipping up some 2c-b and or mescaline vapes. Apparently 2c-B vape carts are a thing. I would guess that a mescaline vape does work, however, i wpuld expect it to taste terrible, potentially be corrosive to mucous membranes, and impotent enough that several tokes would be required.

One would have to convert to the freebase of course.

Certainly not a priority tho.

I've heard of people vaping 2C-x hydrochlorides in PG/VG and a friend currently is dabbling with vaping a-PVP benzoate, which makes me want to try 2C-D benzoate vaping.

 

[Didgital]

I've heard of people vaping 2C-x hydrochlorides in PG/VG and a friend currently is dabbling with vaping a-PVP benzoate, which makes me want to try 2C-D benzoate vaping.

2C vapes are a thing, I've not tried personally. Am told it's pretty instant and lasts a few hours which doeesss sound appealing i must say.

 

[idle_curiosity]

Purely anecdotal, but I found vaped freebase 2C-B to be noticeably different than oral, more stoning/dopey in feeling. Its sibling, 2C-B-Fly, freebased and vaped was a disappointment and I didn't find it worked well nasally either (in salt form - wasn't wildly painful, but not very effective). However, 2C-E, 25E-Nboh and DOC all worked well for me via the freebase, vaped route; I'd even go as far as saying they're better that way, especially DOC which I didn't enjoy orally at all.

 

[xdrc]

2C vapes are a thing, I've not tried personally. Am told it's pretty instant and lasts a few hours which doeesss sound appealing i must say.

Yeah, an acquintance claimed around 12 mg 2C-B HCl vaped on foil on top of say 30 mg 2C-B HCl oral (or something around that dose) was similar in visual intensity to DMT but retained the friendly character of 2C-B. He tried to encourage me to do it multiple times. Personally I'd prefer vaping a salt with low chance of pyrolysis, I think the benzoates may be good candidates provided they dissolve well enough. I think 2C-D benzoate would be a good candidate meeting the criterium of low chance of pyrolysis while perhaps being soluble enough. Personally I find DMT freebase a bit harsh on my lungs so I'm not too eager to vape PEA fb.

 

[red22]

Can someone try vaping LSD?

 

[Didgital]

Yeah, an acquintance claimed around 12 mg 2C-B HCl vaped on foil on top of say 30 mg 2C-B HCl oral (or something around that dose) was similar in visual intensity to DMT but retained the friendly character of 2C-B. He tried to encourage me to do it multiple times. Personally I'd prefer vaping a salt with low chance of pyrolysis, I think the benzoates may be good candidates provided they dissolve well enough. I think 2C-D benzoate would be a good candidate meeting the criterium of low chance of pyrolysis while perhaps being soluble enough. Personally I find DMT freebase a bit harsh on my lungs so I'm not too eager to vape PEA fb.

It wouldnt be difficult to make the fb but it will most certainly be an oil. I think vaping the salts prolly not a good idea

 

[General alcazar]

I’ve tried vaping 2cs in an oil burner with no effect (or at least minimal compared to oral). Personally, for instant effects, IV is the best. IM is so painful that it detracts from the experience. However, it is much stronger, and dose should be scaled down to 20%. I haven’t tried to dissolve in PEG. I wonder if an oil burner is too hot and degrades the product. I also haven’t tried to convert to freebase. Guess something to assaying in the future.

 

[xdrc]

It wouldnt be difficult to make the fb but it will most certainly be an oil. I think vaping the salts prolly not a good idea

There is no problem with handling the oil especially dissolved in PG/VG though. However please note that problems with pyrolysis from bad salt choices aside, vaping amine salts is not uncommon and can actually help against throat irritation from the alkaline pH, see nicotine salt vaping. The salts get carried over in the boiling/atomised PG/VG.

 

[General alcazar]

Oral for 2c-x’s feel like plenty. Coming up on 2Cs from any parenteral route is, quite frankly, alarming. The only ones I’ve tried it with are 2CC and 2CD. I wouldn’t go there with any of the others. I expect that doing so would be hazardous. Maybe PEG vaporization delivers the product more slowly, but I doubt it. I suppose a question to ask while on topic, is if is it’s worth converting to a free base first?

 

[xdrc]

TEK: Smoking Mescaline(-Benzoate)

[Originally thread started as a theoretical question, but now with all the data provided I replaced the original text. You can read it at Post #3, so the discussion along this thread was based around that text, not this current one] So here is a TEK that can be used to convert Mescaline...

forum.dmt-nexus.me

 

[Didgital]

There is no problem with handling the oil especially dissolved in PG/VG though. However please note that problems with pyrolysis from bad salt choices aside, vaping amine salts is not uncommon and can actually help against throat irritation from the alkaline pH, see nicotine salt vaping. The salts get carried over in the boiling/atomised PG/VG.

I only mentioned it because the oil is def a bit more difficult to handle physically. If I was gonna do such a thing and didn't have access to a rotoevaporater, I would dissolve the salt in water, bring to ph 12 and stick in freezer. The oil will likely stick to sides of container. Pour off/decant water through coffee filter, and scrape the oil, dissolve in pg. Titrate dosage. I've no idea what concentration is ideal. With such potent materials (especially the freebase) I would expect mechanical losses during this process.

 

[Allylbenzene]

I've heard of people vaping 2C-x hydrochlorides...

The 3,4,5-TMeO format of PEA seems to be handled in a rather unique way meaning that vaping it likely isn't a very effective nor efficient ROA. The phenylethanol might be more suitable actually due to volatility, and this format ensures the aldehyde prerequisite step can occur.

 

[xdrc]

The 3,4,5-TMeO format of PEA seems to be handled in a rather unique way meaning that vaping it likely isn't a very effective nor efficient ROA. The phenylethanol might be more suitable actually due to volatility, and this format ensures the aldehyde prerequisite step can occur.

Carefully (!) take mescaline with a MAO B inhibitor and drop your strange aldehyde theory.

 

[Allylbenzene]

...mescaline...drop your strange aldehyde theory.

You seem to have some sort of bias or prejudice 'against' the notion that perhaps current consensual understanding of mescaline pharmacokinetics is inaccurate. Usually people assume a consensual truth is absolute – until they don't. The more close-minded people tend to have great difficulty perceiving new ideas.

...take mescaline with a MAO B inhibitor

Why would I do that? Mescaline isn't particularly an MAOB substrate. More-so it's a substrate for SSAO. Even though the 2nd paper cited is dated 2009, I only learned about the relevance of SSAO (for mescaline) a few years later in 2011 but it's normal for things like this to be overlooked by most people.

The [SSAO] enzyme catalyzes the oxidative deamination of primary aliphatic and aromatic amines, such as tyramine, dopamine and 5-HT, with substrate specificity partly overlapping that of the MAOs (source)

https://doi.org/10.1351/pac200173091393

 

[idle_curiosity]

TEK: Smoking Mescaline(-Benzoate)

[Originally thread started as a theoretical question, but now with all the data provided I replaced the original text. You can read it at Post #3, so the discussion along this thread was based around that text, not this current one] So here is a TEK that can be used to convert Mescaline...

forum.dmt-nexus.me

I'd argue that vaping freebases is more safely and efficiently achieved by using a steam distillation approach. Making sure there's another lower boiling vapour carrier phase in the mix greatly reduces the likelihood of thermal degradation while increasing vapour production and transport. In practical terms this can be as simple as mixing the freebase with a moist substrate (damp tea leaves will do). Using an electronic temperature controlled weed vape reduces the chances of pyrolysis to almost zero. Other carrier phases like glycols work similarly.