Towards the end of a binge it can take more than that to get me in a hole though.
I don't think I've ever required more than ~175mg to hole out even at my heaviest tolerance during my heaviest binge, but then a couple weeks later I slipped into a hole off ~75mg. Idk why my tolerance resets so hard, I suspect that noopept and memantine usage may relate but I've got genuinely no clue tbh.
I suppose you could argue it's a difficult drug to dose compulsively because you just end up forgetting what you're doing
That's a good point hahaha, I also experience intense tachyphylaxis from ketamine where the doses over the course of a day become progressively weaker and weaker, similarly to what happens with cannabis or nicotine for most people where the first hit of the day will typically hit the hardest. Ketamine and cannabis occupy very similar places in my life, honestly. People look at me weird when I say it, but THC, nitrous, salvia, memantine, and arylcyclohexylamines (ketamine, PCP and friends) all occupy the same space for me. They are all dissociative drugs that induce an altered state that allows me to affect some degree of change over my own mind.
Hadn't even heard until MXE until after it was banned. Where's the clandestine market for that anyway? Sure seems to be enough demand for it even years after it was globally scheduled.
You should always consider any arylcyclohexylamine with a 2-keto substituted cyclohexane as being significantly harder to make,
especially in clandestine settings. I've known of people to accomplish this in clandestine contexts but the yields are garbage and it's a messy, dangerous process overall when compared to making simpler arylcyclohexylamines which most people would classify as being PCP analogs as opposed to ketamine analogs. There are three routes I'm familiar with which could lead to MXE, all three of which involve some tricky precursors to acquire, but they're the same precursors you'd need for 3-MeO-PCP and 3-MeO-2'-Oxo-PCP (aka MXPCP) which people still make from time to time, so I know people are acquiring these things somewhere. You could view MXE as 3-MeO-2'-Oxo-PCE as opposed to the PCP homolog which would be MXPCP, just swapping out an ethyl group for a piperidine pretty much. The demand for it might seem high, but I really doubt it would be worth the pain in the ass of producing MXE when you could instead just make 3-MeO-PCP which requires less mass for a full dose.
OT: Today's been a serious polypharmacy clusterfuck. I had established this combination of very specific doses of memantine, methamphetamine, bupropion, caffeine, and MGM-15 that induced consistent states of productivity and mood stability which I'd never even come close to. Today I emulated the same thing but with 600mcg of intranasal buspirone, and it was pretty eh. Didn't really help things, kind of sidetracked me a little bit. As the five-drug-clusterfuck began to wear off, I hit the etizolam and cimetidine a little bit to just get groovy and chill to some genuinely cryogenic extents.