Misc What is the ACTUAL most potent drug on the planet? No bullshit like crack or cocaine (even though they are potent).

[Rectify]

14-MeO-Oxycodone Is Definitely One Of The Strongest Actual Drugs On The Planet.

14-MOO aka 14-MeO-Oxycodone

 

[Them Witches]

Fuck IV clonidine. I mixed it with morphine once and it knocked the breath out of me. Fuck that

What did you that for?

Duraclon isn't for everyone. Two different worlds b/t a Clonidine tablet and IV shot.

Precedex (Dexmedetomidine) is so strong it has to be given over timed infusions. It is about 3-5 times stronger than Duraclon. "Dex" is about 3 times stronger than Medetomidine (the new stuff found in the Philly tranq-dope.)

Dexmedetomidine comes in a sublingual film for mental health reasons - 120mcg or 180mcg

Precedex (generic name dexmedetomidine) is a fast-acting intravenous sedative and pain-relieving medication primarily used in hospital intensive care units (ICUs) and operating rooms. It is highly valued because it calms patients and mimics natural sleep without significantly depressing breathing

Alpha-2 drugs and opioids work well for pain and trauma.

 

[Them Witches]

14-MeO-Oxycodone Is Definitely One Of The Strongest Actual Drugs On The Planet.

14-MOO aka 14-MeO-Oxycodone

Bring it on. I am sponsored by Mallinckrodt 30mg IR.

I want the Oxyfast -- Oxycodone solution 20mg/1mL strength please...

 

[TheOriginalZywinzi]

I'm curious about this part of the question! What do you mean, no 'bullshit'?! If we're talking about most potently euphoric, then why would we disregard crack and coke?! Those are two of the best contenders!

IV cocaine is said to be so potently, intensely euphoric, that it can cause "uncontrollable vomiting". Man, something that causes you to chunder out of sheer pleasure sounds like it should be included in this highly subjective ranking discussion. And then there's crack, which is said to cause experiences which are outside the sensory realm attainable through normal human experiences.

I just find it weird to classify these as "bullshit" and seem like they're a waste of time in this discussion. Maybe OP is hoping that someone will reveal some ol' crazy shit (but not bullshit) which is 10x the subjective potency of crack and fent combined and causes the user to orgasm so hard they die in ecstasy. There are plenty of super hedonists out there and I'm sure they would've uncovered all the really feelgood stuff already. so unfortunately OP may just be stuck with boring old bullshit crack, IV MDA, and carfentanil injected straight into the eyeballs.

(Or slapping seals. I hear that's quite the rush.)

I was an iv coke addict in 2024, i have a few posts under this account on bluelight from back then speaking on it. The answer to this thread, as someone who has done 60+ different drugs of all types, is indisputably IV coke, and it's not particularly close for me... even IV heroin does not come near the pure hedonistic euphoria of IV cocaine

 

[Didgital]

Cocaine is not potent.. powerful yes although there are many other drugs I consider more powerful (5-meo-dmt, salvinorin a etc)
powerful ≠ potency

I believe there are one or two synthetic fentanyl analogues that are more potent than carfentanil but they relatively obscure and don't even have a common/code names yet.
Even for carfentanil, I can't find a typical dosage for it (for humans), but if it's 100x stronger than fentanyl, and a fatal overdose of fentanyl is 2mg (2,000ug) then a potentially fatal overdose of carfentanil is as low as 20 micrograms.

I genuinely can't think of any other psychoactive/recreational drug that is as potent by weight, not that I really consider it a recreational drug.

There is also ETH-LAD (typical dose = 80 ug ) is probably the winner as far as recreational substances as it is just a bit more potent than LSD itself (typical dose = 100ug)

ETH-LAD - Wikipedia

en.wikipedia.org

 

[DeathIndustrial88]

Just to play semantics here...

Potency does not always equate to "good effects" or better euphoria.
A drug can be incredibly strong, potency-wise, but still produce less enjoyable effects than a drug that's less potent.

Buprenorphine is 45x more potent than morphine, but it's not as enjoyable as morphine. Fentanyl is like 50x more potent than morphine & heroin, but I think heroin is 100x more enjoyable than fentanyl.

Tramadol is incredibly weak potency-wise, but 200-400mg of tramadol is MUCH better in terms of effects (to me) compared to taking 10-20mg of hydrocodone.

So I assume you actually mean which drug causes the strongest euphoria? I think that'd probably be subjective.

 

[TheLightBringer]

Hmm, since it seems youre asking for most intense experience not most potent by weight. Its quite a subjective experience I guess

For me personally I would have to put a 3-MeO-PCP overdose up there, its quite unlike anything ive experienced. And the earlier parts that I do remember from the experience were stronger than any DMT or Salvia experience ive had beforehand, and ive probably taken DMT ~50 times in my life.

Also I find non-hallucinogen and non-stimulants to be quite difficult to categorize as ”intense”. As the experience can reach a high level of intoxication or euphoria but the higher I dose the less present and more numb I feel, always felt mellow on most depressants no matter how much I took.

For hallucinogens Im gonna be boring and say 3-MeO, LSD, DMT, Salvia
In terms of stimulants probably pyrovalerones are some of the most intense substances ive done.

 

[Rectify]

Bring it on. I am sponsored by Mallinckrodt 30mg IR.

I want the Oxyfast -- Oxycodone solution 20mg/1mL strength please...

I'm Just An On Paper Chemist, But If You Have Mallinckrodt Oxycodone, The Wlliamson Ether Synthesis Of 14-MOO (14-MethOxy-Oxycodone) From Oxycodone Is Just One Laboratory Chemist And One Purchase Order Of NaOMe Away. Potent, Very Potent. Achtung, Baby.

 

[Didgital]

Ok, I know thread is mainly concerning the power of a substance and not specifically potency but.... I just want to discuss potency by weight a little more.

I did a little digging, there are analogues of fentanyl such as Ohmecarfentanil (and others) that are 30000x more potent (by weight) than morphine. Carfentanil is 5-10000x more potent than morphine. That would put these analogues 3-6x more potent than carfentanil. Potential fatal overdose as low as 3-6 micrograms.
A gram contains 1000mg each containing 1000 micrograms. So 1000 x 1000 / 3 = 333,333x potentially fatal overdoses in a SINGLE gram.
A single kilogram of this substance could kill almost the entire population of the united states and 5kg would be enough to kill everyone on the planet.

I'm pretty sure it may be the most potent drug known to man.

Ohmecarfentanil - Wikipedia

en.wikipedia.org

 

[Jnowhere]

At what point do these analogs

Like mg-for-mg
Probably one of the Fentanyl analogues that are like 10,000 times stronger than morphine

At what point do these "analogues" stop being drugs, and are just a poison?

 

[ChemicallyEnhanced]

At what point do these analogs

At what point do these "analogues" stop being drugs, and are just a poison?

Agreed. Like, they say if you look at 2 grains of salt, that is what a fatal dose of Fentanyl looks like for the average person. So imagine one of the analogues that are 100 x stonger than Fentanyl :/ We're talking about doses that are not even visible to the naked eye. 'Cause that would be 1/50th the size of a single grain of salt.

 

[BadBoy377]

Salvinorin or LSD if we're going by weight. T

Freebase cocaine if we're talking sheer intensity and inducing composition 6i8

 

[Them Witches]

I'm Just An On Paper Chemist, But If You Have Mallinckrodt Oxycodone, The Wlliamson Ether Synthesis Of 14-MOO (14-MethOxy-Oxycodone) From Oxycodone Is Just One Laboratory Chemist And One Purchase Order Of NaOMe Away. Potent, Very Potent. Achtung, Baby.

Mallinckrodt 15mg and 30mg are still "crush under thumb" construction without a "pill coating"

 

[Rectify]

I Read In A Scientifically Published Article That 14-MOO Is 1,000,000x Stronger Than Morphine.

 

[crazyotter87]

Ok, I know thread is mainly concerning the power of a substance and not specifically potency but.... I just want to discuss potency by weight a little more.

I did a little digging, there are analogues of fentanyl such as Ohmecarfentanil (and others) that are 30000x more potent (by weight) than morphine. Carfentanil is 5-10000x more potent than morphine. That would put these analogues 3-6x more potent than carfentanil. Potential fatal overdose as low as 3-6 micrograms.
A gram contains 1000mg each containing 1000 micrograms. So 1000 x 1000 / 3 = 333,333x potentially fatal overdoses in a SINGLE gram.
A single kilogram of this substance could kill almost the entire population of the united states and 5kg would be enough to kill everyone on the planet.

I'm pretty sure it may be the most potent drug known to man.

Ohmecarfentanil - Wikipedia

en.wikipedia.org

Huh, I was under the impression that 4-F-Ohmefentanyl was the most potent fentanyl analog to ever exist. Looking at the Wikipedia page, it appears it was discovered after an old article I read came out. Here is a link to it if anyone is curious. It is a good, quick read: https://www.vice.com/en/article/hamiltons-pharmacopeia-804-v16n4/

 

[crazyotter87]

I Read In A Scientifically Published Article That 14-MOO Is 1,000,000x Stronger Than Morphine.

"14-Methoxymetopon is a potent opioid analgesic. When given systemically, it is approximately 500-fold more active than morphine. However, this enhanced potency is markedly increased with either spinal or supraspinal administration, where its analgesic activity is more than a million-fold greater than morphine."

14-Methoxymetopon, a very potent mu-opioid receptor-selective analgesic with an unusual pharmacological profile - PubMed

14-Methoxymetopon is a potent opioid analgesic. When given systemically, it is approximately 500-fold more active than morphine. However, this enhanced potency is markedly increased with either spinal or supraspinal administration, where its analgesic activity is more than a million-fold greater...

pubmed.ncbi.nlm.nih.gov

 

[bratchny]

Meth comes to mind.

But actually it's Charlie Sheen.

for some people. the social circle that I went fast and turned left in, meth was almost used how normies or people in movies go about handling alcohol. Show up at someone's house randomly, instead of a cocktail offered,the bong would be packed and smoked. It was just common decorum. I guess shit used to be way stronger, but for some people the stuff that's around today is gonna trigger any kind of psychological bomb you might have that was sitting dorment, waiting for the right chain of events or mental distress to go off take over the seemily normal cognition a person has used to navigate life up until that point. I don't think that meth alone can cause any of the schizo type disorders people usually associate with its use. I think that something was already there. Whether that disorder would manifest and become a part of of someone's life have it not for the meth, I'd say yes, but I think it needed to be either passed down, or some environmental influence while our brains were developing.

as far as gnarliest drug, I don't think that's a one answer question. There is way to many directions or ways a drug can be. DMT is the only drug that when it's effects mellowed out, I had to ask, "were my eyes open". For me all opiates are kinda the same. They have been part of my life for so long in forms from ground up poppy pod tea and kratom, to pharmy dope, opium, heroin, and unfortunately now fentanyl. Yeah a smaller amount of fentanyl will get me higher than some west coast tar, so I guess it's more potent but it's all just opiates. Just one fucking rails dick dust for breakfast, and the other I miss as much as we miss whatever we get nostalgic about. I just reread the question and it's potent, not what drug is strongest. hands down DMT. a few hits of that will effect you more than any other drug. I've gotten close with ketamine but it took way more and still really wasnt close it was just similar, sort of.

 

[Didgital]

At what point do these analogs

At what point do these "analogues" stop being drugs, and are just a poison?

you're not wrong.

i think

Agreed. Like, they say if you look at 2 grains of salt, that is what a fatal dose of Fentanyl looks like for the average person. So imagine one of the analogues that are 100 x stonger than Fentanyl :/ We're talking about doses that are not even visible to the naked eye. 'Cause that would be 1/50th the size of a single grain of salt.

this is why they haven't been distributed.
They so potent they cannot be safely be distributed to ppl.
the fact that carfententil shows up occasionally is a bit shocking. There is no safe dose... I was just extrapolating off of morphine equivalents.

I once saw saw carfentil with my own eyes..

Kid was showing me, nodding out and broke the vial all over the table in front of me.

 

[Didgital]

I Read In A Scientifically Published Article That 14-MOO Is 1,000,000x Stronger Than Morphine.

clarify por favor?

 

[Didgital]

Huh, I was under the impression that 4-F-Ohmefentanyl was the most potent fentanyl analog to ever exist. Looking at the Wikipedia page, it appears it was discovered after an old article I read came out. Here is a link to it if anyone is curious. It is a good, quick read: https://www.vice.com/en/article/hamiltons-pharmacopeia-804-v16n4/

no theres a few others.. they don't even have code names..
can link the article if u want.

honestly from the paper i read, they almost cant read the potency of some of the analogues they so potent.

Im personally seeing Orphines as the next wave sadly