Quetiapine (Seroquel) as a trip killer

[Flynnal]

A drug with similar effects to quetiapine is mirtazapine, just without that dopaminergic antagonist activity. I can tell you one thing the mirt does well, that is, kill a lot of the nerve pain that I struggle with (due to the hydrocephalus I was diagnosed with a year or so after a major COVID infection caused an onset of nerve pain on the side of my face). Amitriptyline works wonders for nerve pain, but for killing trips, nah, it would make them worse, or could even lead to serotonin syndrome. Mirt is a good trip killer, just not as potent as quetiapine or olanazapine.

 

[NoiseNinja]

My .02
Seroquel (quetiapine) was prescribed for me around 2004 when I was in recovery from a few years of crack binges. It was guaranteed to prevent or adjourn "committee meetings" that are notorious for really shitty nights with little sleep. 20 minutes or so after taking my prescribed dose it was lights out and a good restful sleep.
Valium was always the parachute for stopping or sliding out of a bad LSD or Shroom trip, at least in the 70s, 80s, and 90s.
If Seroquel does the job as it seems to be reported here, I'd say that's great.
My 1st trip was when Raiders of the Lost Ark was still in movie theaters (Blockbuster rented VHS tapes and Netflix sent DVDs in the mail) As intense and fun as the movie was, the white clamshells mixed into the asphalt black parking lot were fun too, as they appeared to be standing up out of the asphalt an inch or 2.

My experience with Quetiapine is that it feels like it sucks the energy out of your body, but you don't really get mentally tired, so for me it was a really shitty sleeping medication.

It just makes me feel like shit physically, while the brain is still running on more or less full power.

And when you do fall asleep anyway, no thanks to Quetiapine, it makes sure your body is still groggy the day after.

But maybe that is just me.

Never tried it to kill trips though.

 

[Featherfall]

My experience with Quetiapine is that it feels like it sucks the energy out of your body, but you don't really get mentally tired, so for me it was a really shitty sleeping medication.

It just makes me feel like shit physically, while the brain is still running on more or less full power.

And when you do fall asleep anyway, no thanks to Quetiapine, it makes sure your body is still groggy the day after.

But maybe that is just me.

Never tried it to kill trips though.

this is really interesting cause for me it basically cleaned out my entire brain of thoughts whenever i took it

 

[4DQSAR]

As far as I know, while very occassionally quetiapine (Seroquel) is encountered on the street, there are very few takers. The duration appears to be extremely long and it only seems to be valued by users who essentially want to knock themselves out for 24 hours.

It is true that such people are out there but then it's amazing what some people will do for ANY kind of ASC.

If you end up in hospital due to overuse of psychedelics, usually diazepam and a lie down are the preferred option. But cut up rough and you may discover just how easy it is to section someone. 28 days in a 'prison with potplants' is a hefty price to pay.

 

[vision conquest]

A drug with similar effects to quetiapine is mirtazapine, just without that dopaminergic antagonist activity. I can tell you one thing the mirt does well, that is, kill a lot of the nerve pain that I struggle with (due to the hydrocephalus I was diagnosed with a year or so after a major COVID infection caused an onset of nerve pain on the side of my face). Amitriptyline works wonders for nerve pain, but for killing trips, nah, it would make them worse, or could even lead to serotonin syndrome. Mirt is a good trip killer, just not as potent as quetiapine or olanazapine.

I was just about to say this exact thing....except for the nerve pain as I have never experienced that.

I have however tried LSD while on a stable dose of 30mg mirtazapine daily and the LSD did basically nothing and I know they were good trips as there were plenty going around at the time and all the reports were that they were good.

After doing some reading it appears to my limited knowledge of pharmacology that mirtazapine would also make MDMA a waste of time, can anyone confirm this one.

 

[4DQSAR]

Mirtazapine is 5HT2A/B/C antagonist and WILL compete for receptor occupancy. It's probably a safer bet than an antipsychotic and in fact finds niche use in MDMA-induced depression.

Be it LSD or MDMA, it will probably at least compete and taking MORE to overcome a prescribed medication is probably not a great plan.

 

[Themailman]

Quetiapine is only a potent 5ht2a antagonist at doses of 200mg or more. I typically use 100mg to "abort" a trip, because this will bring me down enough to be comfortable but does not stop hallucinations, only dulls them. But it also completely ruins the afterglow which is the worst part of taking APs to abort.

This is just my anecdotal experience. If you truly need to immediately abort a severely bad trip I would recommend stronger APs like risperidone or olanzapine. Risperidone has been medically described as "the perfect antagonist to LSD". It will stop even LSD overdoses with just a few milligrams, and begins to do so within 30 minutes in my experience (but its also a hardcore neuroleptic with a long half life so only use in emergency), seroquel typically takes more like an hour to start killing trips because of its neurological promiscuity. It also primarily acts as an anticholinergic like benadryl at lower doses... off topic but I prefer taking 12.5mg of quetiapine over 50mg of DPH when I need sleep, and I generally have a strong aversion to antipsychotics. It doesn't really attach to serotonin receptors at that dose and feels like a cleaner version of benadryl to me.

 

[4DQSAR]

Quetiapine is only a potent 5ht2a antagonist at doses of 200mg or more.

OK, I will bite. How was that conclsion reached?

 

[Themailman]

OK, I will bite. How was that conclsion reached?

Vague memory of some paper I read and a half memory of speaking with an unintelligently dispositioned shrink. I admit I am guessing by memory. Might be +-50 mg but i don't think I'm wrong

Have you ever taken quetiapine? 25mg feels a lot different than 200mg or more.

Its the only neuroleptic which is often off label prescribed for sleep. This is because doses of <50mg have very little effect at the traditional sites of d2 and 5ht2, because at lower doses for whatever reason it prefers to fill up the anticholinergic receptor first, which for me feels like a cleaner version of benadryl with less side effects. Im actually just guessing again from memory, look at me go. I've read a lot of medical literature over the years.