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Stimulants Bupropion + Methylphenidate combo

Axemancometh

Axemancometh

Bluelighter
Joined
Mar 12, 2026
Messages
66
Location
Canada
I have a homie that loves this combo. He says it gives him the same sort of euphoric lift and energy as ecstasy. I have never touched either, though I could easily get my hands on them. Have any of you stim tweakers tried this combo?
 
Well both lower a person's seizure threshold, can produce tachycardia and/or hypertension and/or anxiety.

I believe the combination is occassionally used in the treatment of ADHD as both are NDRIs.

I really have no idea if any interaction has many medical benefits but the combination is said to carry a moderate to major risk, particularly that seizure threshold. It's worth noting bupropion also acts on the nicotinic receptors making it's activity even more complex.

Lots of things are possible - many of them only once.
 
4DQSAR said:
Well both lower a person's seizure threshold, can produce tachycardia and/or hypertension and/or anxiety.

I believe the combination is occassionally used in the treatment of ADHD as both are NDRIs.

I really have no idea if any interaction has many medical benefits but the combination is said to carry a moderate to major risk, particularly that seizure threshold. It's worth noting bupropion also acts on the nicotinic receptors making it's activity even more complex.

Lots of things are possible - many of them only once.
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Yeah... I told him about the seizure thing - He does not seem to care all too much.

I don't really understand why you wouldn't just want to take extra Bupropion or Methylphenidate. They are essentially just speed - though taking Benadryl with DXM also weirdly potentiates it, so maybe there's some hidden synergy with these two that I don't know about.
 
Well burprion appears to act at the tetrabenzapine site but methyphenidate acts via other sites so I suppose it's possible they can act in concert but as I understand it, it's not a common combination.

I think only people who have had full-on tonic-clonic seizures who can point out just how dangerous they are. If alone, possibly fatal.
 
Bupropion has negligible effects at the DAT 20-30% ….not enough ….its nicotinic rec antagonist and mostly active at the NET. Also, the seizure issue was largely blown out of proportion, as my doctor stated before I took Wellbutrin but the damage was done….its listed for liability reasons. DDI’s and various others COULD cause, so it’s listed so no lawsuits are filed. Maximum adult dose is 450mg. There’s a large 300mg XR tablet and a smaller 150mg XR tablet. If someone takes more or different ROA and has seizure too bad I guess ….I researched Bupropion seizure in medical journal review after my doc said it’s unlikely and the literature backed up my docs statement.

Methylphenidate is 3-4X more potent at the DAT than the NET ….and therapeutic dose inhibit more than 50% of DAT and fully capable of inducing euphoria, elation, mood-boosting antidepressant effects….while possessing a relatively safe cardiovascular profile. Very low increases in HR & BP as compared to the amphetamines

Ritalin (Methylphenidate) is lightyears away from Wellbutrin (Bupropion) as a euphoric dopaminergic stimulant although Bupropion can be added to the regiment working in the background in its XR formation as IR Ritalin is short acting 3-4h max

It’s a relatively safe combination when used in proper therapeutic doses and carefully adjusted/increased when initiating treatment.

I found Bupropion 300mg XR effective for a few years……started forgetting shit due to its robust anti-cholinergic properties (it inhibits the neurotransmitter Acetylcholine “the learning neurotransmitter”) so I ceased treatment and was switched over to a real dopaminergic stimulant Ritalin (Methylphenidate) 50-70mg daily.
 
I'm pretty sure a large batch of generic bupropion XR had to be pulled off the shelves in the USA because of dose-dumping which resulted in multiple patients having tonic-clonic seizures. Let's not forget, tonic-clonic seizures kill.

It's the case that both act primarily on the VMAT2 transport and I actually identified that the two bind to different sites within that transport so potentially activity isn't additive but tending towards multiplicative.

There are numerous confounding factors and everyone on BL is just a little picture and a name. So consider it as a total stranger telling you it's just fine to take two different medications that have the potential to kill.

We use the term 'survivorship' bias more broadly to mean that people tend to report positive experiences more often than they post negative experiences, but in this case, the words mean what they say.

I have yet to read a 'trip report' including the words 'and then I died'. Extreme, but it's not like it hasn't happened here with friends and family posting onto the BL Shrine.

I admit that I had forgotten that bupropion also a negative allosteric modulator of some of the nictonic receptors but lest we forget, nicotine itself is a toxin and it's mode of toxicity is, you guessed it - seizures.

It is true that occassionally specialists will proscribe the two medications concurrently but thing such as age, gender, body mass and known comorbities will all be taken into account. Typically a clinicial will reduce the dose of bupropion if it's prescribed as an 'add on'. But it's always based on the metric of the benefits outweigh the risks and even then patientls WILL have the known risks spelled out to them.

I suppose you have to take the time to read the appropriate papers to estimate but one more thing about stimulants is that they can produce insomnia or at best provide poor quality sleep and insomnia and sleep debt also lower a person's seizure threshold. The problem is, without testing, how close to that threshold a person is cannot be guaged.
 
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Blah blah….seek medical advice. As I type this 100,000+ people daily are taking Bupropion 150XR in addition to their IR Ritalin 10mg tablets as needed…..with Clonidine 0.1mg at night time as needed, perhaps even a Trazadone 50mg for any sporadic insomnia and Pregabalin (Lyrica) 150mg X 2 daily

Perfectly safe when tirated by a “medical professional “ …..and not for some high school kid experiencing in their parent medicine cabinet lol

Ok. Disclaimer …..Seek proper medical advice lol…..speak to your local Jobber ;)

Fuuuuuck……lol They manufacture 500mg Diamorphine ampoules which would kill 20 people…..BUT when prescribed by a medical professional that is familiar with your medical condition and tolerance has build under their direct medical supervision, in 10-15 years you’ll be slamming 1/2 gram shots for breakfast

Contact your local jobber…..ask your doctor is hard cock pills are right for you! side effect may occur of an erection lasting four hours or more, please seek medical attention if this occurs and stop medication immediately

Ohhhhh…..the LSD has crept in ha ha …..no offence there amigo …..Soooo sunny here in this beautiful Wednesday after work as I see the light dancing off the enchanting Forrest in my backyard
 
DISCLAIMER- people on LSD may confuse realtity with dreams. Diamorphine is NOT available in 500mg ampoules, just as an example:

BNF is only available in the UK

The NICE British National Formulary (BNF) site is only available to users in the UK (England, Scotland, Wales and Northern Ireland)
bnf.nice.org.uk bnf.nice.org.uk

Even the 100mg format is exclusively used in SYRINGE DRIVERS so patients dying of cancer are given a steady dose of the analgesic over 24 hours.🙄 It's ignorance that kills.

So take all else with that same degree of veracity. Someone confidently using the good old 'this is my experience so everyone else it the same' mixed with a totally lack of understand of how the medicines actually work is a good example of ignorance that can kill.

Be aware some sick f*cks actually like to hand out bad advice on the basis that if they feel down, it's the world's fault so harming others is some form of 'revenge'.
 
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4DQSAR said:
Be aware some sick f*cks actually like to hand out bad advice on the basis that if they feel down, it's the world's fault so harming others is some form of 'revenge'.
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It's true I'm afraid. Great community we have here but there are some people who are reckless (like me) ignorant (me sometimes) and those like my friend describes (definitely not me).

But this guy here ☝️, this guy here is a pure chrome dildo. Solid. He is possibly the most knowledgeable man I know on this subject. You can always trust his advice. Massive respect.
 
Im not a fan of wellbutrin. Ritalin is actually a real stimulant with not alot of side effects for me anyway
 
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