• CD Moderators: nepalnt21
  • Cannabis Discussion Welcome Guest
    Posting Rules Bluelight Rules

Concentrates Muscular soreness after 25:1 cbd/thc gummy

can you elaborate?

i have felt that cbd has slight 5ht (2a?) action, on high doses it feels like a mild shroom comeup imo.
Yeah, choking down that much smoke is a challenge but it feels like a mixture of the empathogenic effects of dangerously high doses of 4F-phenibut, some of the haziness of a high dosed THC edible, and to quite a degree the tactile feelings of MDMA (or perhaps a better comparison would be 5-MAPB). Smoking 3 full grams of a crystal is no trivial task, but that's the point where it felt so good I would take my shirt off and slide across the shag carpet like an inchworm.
 
Why should such reminders even need to be recalled constantly?

Alcohol and benzodiazepines (Xanax, Valium, etc.) act as powerful depressants of the central nervous system, specifically targeting the brainstem and spinal cord. They bind to receptors in that brainstem and hence directly interfere with vital autonomous reflexes such as breathing. A sudden withdrawal carries the risk of inducing severely acute morbid states, as those resulting from a massive neurological rebound due to profound physical dependency adaptations. This abrupt cessation can trigger "Cold Turkey" and even lead to "Delirium Tremens" from such suppression, which actually requires emergency medical assistance to prevent life-threatening complications like seizures, convulsions, choking, up to cardiac arrest.

👼

Opioids (heroin, Fentanyl, OxyContin) also bind to brainstem receptors, which is why an overdose is often deadly in case of a respiratory depression. However, while their type of "Cold Turkey" withdrawal is notoriously agonizing (similar to severe flu-like symptoms such as vomiting and dehydration), it's rarely fatal on its own. Indeed some state of extreme suffering is involved, but vital autonomous reflexes generally remain intact.

Further down the scale, Nicotine withdrawal causes significant systemic disruption (digestive issues, irritability, insomnia) but poses no risk to life.

Finally, Cannabis stands apart as there are virtually no cannabinoïd receptors in a human brainstem. There's simply no biological pathway to "overdose", so calling it just that while ignoring rational science ain't nothing consistent with real medicine. In fact this is a double-standard politically-driven misnomer, worthy of $¢ientology propaganda on top of being physiologically impossible for healthy adults.

☮️
 
There's simply no biological pathway to "overdose"
it's already been dragged back and forth and all over...

to summarize:

you can technically overdose because the definition of overdose is just you took too much.

literally.


overdose​

(OH-ver-dose)
An amount of drug that is more than what should be taken at one time.

and the other side:
in our kinda culture now it really does imply a sort of acute risk to your health that could be dangerous.

is also true.

please let's not keep dishing out blows to the poor dead horse ad nauseum, it's boring
 
...you can technically overdose because the definition of overdose is just you took too much. ... ...please let's not keep dishing out blows to the poor dead horse ad nauseam, it's boring

The opinion that « Too Much » is synonymous with « OverDose » actually makes behavioral excess equivalent to clinical toxicity. It was this sort of reductionist short-cut which prompted the prohibition of alcohol as observed by all history books; money flowed, influence peddling corrupted privileged elites and then their ramshackle house of cards finally crumbled under its weight.

Nonetheless, this paved the way for a meticulously engineered Controlled Substances Act, redirecting stigma and scrutiny toward cannabis while giving alcohol a full pass at every institutional level. Never mind the reversal of biological perspectives when building a regulatory framework, the lack of coherency has effectively become a virtue and society still pays the price today - but who cares?

So, is the plain denial of established science truly 'boring'? Oh yes, and calling such a pivotal discussion just that sure feels like an understatement indeed.
 
in the medical world an overdose is taking more than medically recommended
in the recreational drug use world the word overdose equates to serious risk of death
the middle definition - an overdose occurs when a person takes a toxic amount of a substance—such as prescription drugs, illicit drugs, or alcohol—that overwhelms the body's ability to handle it

*edit, srry nepalnt saw your post after this was posted*


Guy meant it in the medical way apparently as the other two are not really applicable with CBD/THC.

Soreness is not a side effect of too much of either that I know of? (anyone)

That leaves placebo / something else made you sore (MY BET) -- or you got a bad jar of gummies (also highly possible) Too much pectin/gelatin make you sick/sore? Idk
 
i have felt that cbd has slight 5ht (2a?) action, on high doses it feels like a mild shroom comeup imo.

It looks like CBD negatively modulates 5HT2a, inhibits the uptake of adenosine, increases endocannabinoids, directly interacts with 5HT1a, promotes neurogenesis via BDNF-TrkB and causes indirect opioidergic effects amongst other things. It also acts at GPR55 which some call CB3.
GPR55, along with the other cannabinoid receptors CB1 and CB2, plays an essential role in the CNS. ...the study by Reyberg and colleagues shows an antagonistic effect of CBD towards GPR55. The regulation of GPR55 expression by CBD contributes to its anti-inflammatory effects, thus having antidepressant effects. https://doi.org/10.3390/pr13103261

Ironically CBD is marketed as non-psychoactive.
 
Last edited:
Guy meant it in the medical way apparently...

Cannabinoid receptors (CB1 & CB2) first appeared in the common ancestors of vertebrates over 600 million years ago, long before the divergence of terrestrial species and notably among the earliest vertebrates. In humans, these receptors are found only in extremely low densities within the vital centers of the brainstem that autonomously control respiration and heart rate.

Evolution even went a step further: it turns out the human brain synthesizes pregnenolone as a built-in retro-active gain regulator specifically preventing CB1 OVER-activation. It's precisely because of this functional similarity, a biological constant shared by certain mammals, that rats and to a lesser extent dogs are preferred for laboratory testing; despite having between 8 to 12 nipples...

🐀🦮

Human physiology ain't about to change any time soon, not even to accommodate some warped-reality semantics worthy of science-fiction. Had these receptors been present in vital locations, cannabis could have posed a serious threat to health by inhibiting respiratory and cardiac functions, with the dynamic of withdrawal vs adaptation leading to "Cold Turkey". In short, just like chief engineer Scotty’s favorite hard-drug that is never « Too Much » in Star Trek - a 40 oz bottle of Brandy swigged straight from the neck, while in Hollywood no one would care to mention the risk of an alcohol OverDose. Feel free to go figure what's wrong with this picture!
 
you can die from drinking too much alcohol; it happens all the time.

Maybe it is because I am a few shots in I totally missed the point of what you were saying there...... Since those receptors are not in vital locations - that is all sci-fi speculation??

I will step out now as I am not in a great position for logic
 
u know, i actually did wanna add one more thought...

it is PATENTLY false and potentially dangerous to say that "it's impossible to overdose" on cannabis, thc, etc., and i wish ppl would forget that unfortunate cliché.

(unless, of course they're gonna elaborate like we've been doing)
 
...PATENTLY false and potentially dangerous...

Semantic drifts based on a fearmongering "cliché" buzzword such as « OverDose », when applied to cannabis, cause even more harm to the very individuals they claim to protect. It ain't just clinically inaccurate, doing so also actively damages trust in public institutions.

That word has been exceedingly abused while being inseparable from cardiac or respiratory failure in the scientific sense. A rigorous way to preserve an appearance of medical credibility would be to resort to adequately balanced nuances. For instance, why not adopt homeostatic (self-regulatory) overload if we must insist on the "Over" prefix!

Otherwise, society ends up dealing with horrible distortions after crying wolf without factual restraint. In France, a champion of cannabis prohibitionism, young persons whose trust has been badly eroded have actually started to experiment with nitrous oxide (N2O) out of sheer disbelief. Most ironically, a product used for whipped cream became a favourite alternative for unsuspecting consumers: they're now captivated by its convenient availability and lightning-fast blast, sold at a very "honest" cost except it eclipses its safety disclaimers in fine print.

There are more efficient means to communicate legitimate warnings, proper avoidance of trivialization for a word which normally implies a serious potential for lethal toxicity would be a fine start. IMO the receptive readers will benefit most when guided to recognize some pre-existing underlying pathology, for which cannabis merely acts as a triggering catalyst instead of a decoy.

This would help keep an open mind by allowing the exchange of arguments centered on a user's own familiar experience, like anxiety, tachycardia, or intense discomfort - or as people age, even congestion, paroxysmal sneezing, tearing, swelling or pitting edema (...), which could happen to be early warning signs not to ignore because of real dangerous oversight putting all the blame on a plant with the safest LD50 around, while alcohol is omnipresent and opiates get prescribed as if they were candy.
 
Had these receptors been present in vital locations, cannabis could have posed a serious threat to health by inhibiting respiratory and cardiac functions, with the dynamic of withdrawal vs adaptation leading to "Cold Turkey".

But since it doesn't lets not scare the children with a word from the zeitgeist that = death from drugs to them.


In short, just like chief engineer Scotty’s favorite hard-drug that is never « Too Much » in Star Trek - a 40 oz bottle of Brandy swigged straight from the neck, while in Hollywood no one would care to mention the risk of an alcohol OverDose. Feel free to go figure what's wrong with this picture!

Ahh I get it now --- except the parts I didn't address...lol. There was an episode of "Supernatural" where the characters were aware they were characters -- Doctor "How many drinks you have a week" -- About 56, 60 -- "Over how many years?" -- 20, 30 --- "It seems normal to you that you are not dead?" LOL
it is PATENTLY false and potentially dangerous to say that "it's impossible to overdose" on cannabis, thc, etc., and i wish ppl would forget that unfortunate cliché.

(unless, of course they're gonna elaborate like we've been doing)

And I wish that kids knew both definitions of overdose - I make sure to say 'it is impossible to die or legitimately need hospitalization from smoking too much" (Which I stand by panic attacks and freakouts aside)

I find it patently bad for words not to have objective meaning - even worse to go with the less accepted more extreme of the two options to emphasize a point.

(Which is more extreme, pot is completely safe -- Or smoke too much pot you can die)

Subjectivity is always my enemy! *shakes fist*
 
(Which is more extreme, pot is completely safe -- Or smoke too much pot you can die)
hmm... well idk about extreme, but i cosider the first one more potentially harmful/ dangerous than the other one (which doesn't seem harmful at all)... thinking pot is more dangerous than it is seems less dangerous than thinking nothing can go wrong ever because cannabis is so "salubrious and safe".
 
Fair enough - I suppose I am more concerned with the extremity of ppl thinking they could die or need to go to the hospital than I am their learning curve / research on marijuana journey.

I guess completely safe could be harmful if someone hopped behind the wheel or w/e - point taken
 
I find it patently bad for words not to have objective meaning...

This was the important part to read before, displayed in plain view on the last line:

...a plant with the safest LD50 around...

Objectivity has died when answers appear to be addressed to a fictional forged copy of a non-privileged member supposed to have written something the original didn't write, nor is there a fair sense of proportionality considering the title which contained such clickbait word as "OverDose" initially had to be modified just to change the narrative. Expression in absolutes is a serious concern nonetheless, and it does have Public Health consequences as i pointed out.
 
Just had these new combo gummies: cbd (400 mg)+D8 THC (400 mg)+THCP (10 mg).
Jesus christ man 10mg of THC-P is a lot, back when I had a cannabinoid test group in New England (~25 people in total), I had them test 2mg, 4mg, 8mg and 12mg tabs of blotter I'd infused with THC-P, and the 8mg ones had many people violently ill for days, the 12mg ones had people banging on my door claiming I'd poisoned them.
 
THCP is how many times more potent than THC again -- anything else to know about it danger wise -- violently ill doesnt sound normal for a thc product
 
THCP is how many times more potent than THC again -- anything else to know about it danger wise -- violently ill doesnt sound normal for a thc product
Uhhh, well the binding affinity is ~33x Delta 9, but that doesn't mean that it actually is 33x stronger necessarily. It's really the ~3 day duration that most people dislike about it. It can also induce spins/nausea way easier than other cannabinoids, even MDMB-4en-PINACA or 5F-ADB in my experience. One time I had jaundice for a week and couldn't really speak or do anything other than crawl/stumble to the bathroom after eating a quarter of a full gram of THC-P-O Acetate.
 
oh gosh okay ill stay away from that one -- thanks for the heads up. The THC behind it coulda got me if I was in the wrong state and desperate lol
 
Top