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Ketamine Does ketamine build a permatolerance?

k tolerance is a pain in the ass bc it builds slow but lasts a loooong time. if ur a regular user you will eventually develop a stupid high tolerance that wont go away for a long time. a few months break can get u back to a place where you feel Something, but as far as i know theres no easy permanent fix. long breaks help and its good to manage ur use so ur tolerance doesnt keep climbing. if youre a daily user you just gotta be ok with it taking multiple grams in one sitting to feel anything, but in my experience thats far from sustainable.

its weird as fuck bc you will be feeling completely sober till you suddenly k hole. sometimes you wont even know it happened until your buddies say you were stumbling around and couldnt form a coherent sentence :derp: i was taking k in an attempt to help w my anxiety and chronic pain, but daily use just made my anxiety so much worse when i wasnt on it. being a psychedelic and dissociative it has the potential to exasperate mental issues if they arent being properly addressed

k is awesome but you gotta manage your use so you can actually enjoy it. taking a 2-6 month break will help a bit. in my experience only using 2-3 times per month in the long term is best for maintaining tolerance. breaking out of the daily habit is tough, but the first few days are by far the hardest. takes some willpower but the longer you go the easier itll be. just think about how much better itll feel after the break
My experience with ketamine goes back to 1999. Within the first few years of using it I ended up (along with another friend) inheriting a large stash from a dealer-friend who was worried about getting too hot. Having access to that many bottles at such a low price compared to how much we were accustomed to paying made it so easy to pay for the stash, pocket a ton of cash, and absolutely go wild with the stuff. We'd do QBRs (quarter bottle rails) and then get lost in Half-Life 2 or counterstrike. We really pushed into the high-end dose range pretty quickly compared to most people I knew when it came to K. When first trying it, a few small lines would put me into an absolutely devastating dissociative state, later become increasingly unachievable. Tolerance rose to a point where within a few years I moved to IM injections as it was the only reliable way to reach the k hole.

Eventually I got clean from everything and for a few years I didn't use any drugs, after having gone through a 4 year spiral with IV heroin. From 2008-2010, I didn't use any substances at all, but when I started to dabble again it was with ketamine. I found that my tolerance had reset a bit, and I could feel powerful effects from a small amount initially, however after a day or two of using it would surge right back up. It became difficult to use for more than a couple of days without long tolerance breaks to reset.

Over the years, I incorporated some of the RC dissos into the mix - DMXE, MXiPr, MXE, and then the PCP analogs. They all were able to push through my tolerance initially, however eventually the same issues would emerge. I eventually discovered that the only way to use with any reliability and get something enjoyable was to use in very small doses and aim for a different effects profile. Instead of the strong dissociative hallucintory experiences, I would use very small amounts and combine it with things like exercise, kratom, gabapentin etc. This yielded a very pleasant, persistent mood elevation and energy increase. It wasn't typically that inebriating (I could engage in most activities fairly well including long bike rides) but more just shaded my life with this dissociative weirdness, cognitive euphoria, and emotional color. The downside to this approach was that it was very easy to use for days or weeks at a time, inching ever so much into hypomia, paranoia, and irritability. I found that while I would feel better for quite some time, I would also be more reactive and less compassionate. It was also a very difficult psychological dependence to break away from. It felt like I needed dissociatives to simply face the day sometimes.

It's been 8 months since I last used anything, eventually cutting off contact with my regular suppliers of RCs and ketamine, both online and in-person. I also found that moving away from where I was living helped to reset some of the triggers to use that had become a difficult hurdle. I do sometimes miss them and occassionally find myself fantasizing about diving back in but I let the moment pass and find something else to focus on for long enough that the urge subsides. I won't lie and say I don't miss it - I do, sometimes. Dissociatives became such an integral part of my life at such an early point in my life, spanning the end of high school through college and the times up through my opioid addiction. They were the first class of drugs I used when I started to explore again, and in many ways felt like the way I self-medicated for a lot of the tough stuff I faced through the work that I did. Every time I find myself struggling to motivate to go exercise or push myself out of a depressed mood, I think about how easily I could snap into hypomania if I microdosed some ketamine for a few days. I also know that it would reset the clock on tolerance, habitutation, and dependence once again. For that reason, I push past it.

Dissos are tough.
 
Dissos are tough.
My experience as well.

The perma-tolerance thing doesn't seem restricted to the dissos but they certainly seem to have this problem more than other classes of drugs I've used. The last time I had access to K and MXE I could not bust through the wall and reach the hole despite taking very high doses of both. DXM is similar. When I first tried it 300mg or so would put me into space. Now even years later without consuming any dissos at all I could walk around and be coherent. You can tell I'm fucked up but I can still walk, talk and operate machinery I shouldn't be operating.

Dissos and opioids are similar in this respect. In that I can stay off them for months-years and get some positive effects the first 1-2 doses I take when coming back. But tolerance will ramp back up fast and the effects I do get aren't nearly as spectacular as they should be from the amount of drugs I'm consuming. I haven't touched oxycodone in years for example. But the last time I did I consumed about 40mg expecting a good time and maybe a nod. But I didn't feel much of anything. Since my body/brain seems to require 60+mg at a time to get anything positive from that particular drug any more.

I blame my disso tolerance on MXE. I didn't really take dissos often until it came around. It was stronger per weight than K. I got into the habit of taking it everyday if it was around. It was very hard to stay out of the bag. Once I got started I would take small bumps all day then at night I'd shoot for the M-hole. I did that for months until supply was exhausted and couldn't be replaced due to the world wide bans. Since I wasn't looped into the local market for K back then I was unable to source dissos at all other than DXM. Which I tried consuming a couple of times after my fun with MXE but I couldn't get anywhere I wanted to go with it. OTC DXM caused horrible side effects mostly related to the amount of other things in the pills I was taking. So I gave up on that pretty quickly and stayed away.

A few years later a friend gave me about 100mg of MXE from a stash I'd given him back when it was more widely available. It wasn't stored in the best place and had slightly changed color but it was still pretty potent. I decided to shoot for a hole and figured all the time off would allow for me to reach it if I took the 100mg all at once. I took a small tester dose of about 20mg, found out it was still active then consumed the rest about an hour later. It ended up being purely a waste. I felt like I was just outside of the hole but could never reach it. Very frustrating.

Later on I got looped into the local K market. I bought K twice. It was good K and other people were getting to the K-hole without issue with it. I never could no matter how much I consumed. Reaching the hole was going to require bringing the needles out. I hadn't popped my needle cherry and I didn't want to get started. So I gave up and stopped buying K. It was too expensive anyway.

I tried some of the PCP analogs (3-meo-pcp IIRC) and didn't find them very enjoyable. They didn't have the warmth of MXE and I never got anywhere near a hole. It provoked panic attacks in multiple people I knew personally. It wasn't fun. One friend did something really dumb on it because he stayed up for 2-3 days taking casual bumps off the bottle. I was happy when he lost the stuff. All I got from it was a penis rubbed raw from a multi-hour masturbation session.

It's going on over a decade now since I last tasted MXE. I'm willing to bet anything that if I had some right now my tolerance would still be sky high. Of course I would try. But I doubt I would purchase it in the first place. Got too spoiled by what it cost back when it first hit the scene.

MXE is still my favorite drug ever though. I rank it above even morphine. If I'd known things would go the way they did I would have bought 1,000 kilos of the stuff before it got banned world wide. I'm still shocked no one on the black market is producing it. I thought for sure it had gained a large enough following to make it a viable business decision once the bans took effect. I don't understand why it vanished so quickly when K still seems to be widely available.

There is nothing that compares to a proper hole experience.
 
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k tolerance is a pain in the ass bc it builds slow but lasts a loooong time. if ur a regular user you will eventually develop a stupid high tolerance that wont go away for a long time. a few months break can get u back to a place where you feel Something, but as far as i know theres no easy permanent fix. long breaks help and its good to manage ur use so ur tolerance doesnt keep climbing. if youre a daily user you just gotta be ok with it taking multiple grams in one sitting to feel anything, but in my experience thats far from sustainable.

its weird as fuck bc you will be feeling completely sober till you suddenly k hole. sometimes you wont even know it happened until your buddies say you were stumbling around and couldnt form a coherent sentence :derp: i was taking k in an attempt to help w my anxiety and chronic pain, but daily use just made my anxiety so much worse when i wasnt on it. being a psychedelic and dissociative it has the potential to exasperate mental issues if they arent being properly addressed

k is awesome but you gotta manage your use so you can actually enjoy it. taking a 2-6 month break will help a bit. in my experience only using 2-3 times per month in the long term is best for maintaining tolerance. breaking out of the daily habit is tough, but the first few days are by far the hardest. takes some willpower but the longer you go the easier itll be. just think about how much better itll feel after the break
Thanks. Yeah I was taking 10 grams a week but I've been off it all 2026 so far
 
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