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Drug designs. (MedicinalUser SAR thread)

This is my new design based on DOT:

pubchem.ncbi.nlm.nih.gov

PubChem

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Smyth2 said:
This is my new design based on DOT:

pubchem.ncbi.nlm.nih.gov

PubChem

PubChem is the world's largest collection of freely accessible chemical information. Search chemicals by name, molecular formula, structure, and other identifiers. Find chemical and physical properties, biological activities, safety and toxicity information, patents, literature citations and more.
pubchem.ncbi.nlm.nih.gov pubchem.ncbi.nlm.nih.gov
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That's an interesting design, Now I would expect a compound lacking those two methoxy groups to be akin to the benzofuran series i.e. 6-APB and homologues.

Be aware that PEAs containing a para sulfinyl moiety often demonstrate significant MAOI activity. So I would begin with simply moving the S to the 3 position. Just because based on limited evidence, it MAY prove to be safer.

If your recall, I did ask about 1-(2H-1,3-benzoxathiol-5-yl)propan-2-amine being a potential MDA alternative some time go BUT your idea is better. Because my idea would still be considered (legally speaking) as a ring-substituted PEA.

Great idea!

Now, how to make such a thing? Starting with the simplest example (1-(1-benzothiophen-6-yl)propan-2-amine). CAS 6386-80-7 is likely to be the ultimate source. But just to trmind you, neither the nitroalkanes and nitroolefins are controlled. Why? I don't know, I can only guess. But that is the case.

A bit of history, the (not) 'inventor' of Benzo Fury discovered that the chloromethylation of benzofuran was the most facile starting point BUT there were always positional isomers found in all the samples whose instrumental data I've seen. Now that likely is classic 'good enough' as Chinese manufacturers would consider the product, but if you really want to test the pure material, I suspect you may need to begin with that aldehyde.
 
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