Lysergamides GABA + LSD - "For this is where God lives"

[Esperighanto]

Off topic but kinda on topic , I want to get back into psychedelics for my first time coming back I was wondering 0.25-0.5mg Xanax 10 minutes before 4-HO-MET I like visuals without headspace or would y recommend 2CB with Xanax ?
I only have experience with mushrooms and n,n,DMT

If you're aiming at an empty-headed, thoughtless bimbo-vibed kind of trip, then metocin on its own is already good enough for that in every experience I've ever had with it. I genuinely find metocin to be a waste of time because it's eyecandy with no thoughts, and it creates a tolerance to where I can't then use more useful psychs for a few days. As far as hedonism goes, 2C-B with alprazolam would be a banger imo, I personally think that metocin is the most overhyped toy that people group together with tools as profound as the other 4-substituted tryptamines.

 

[Ismene2]

Try adding a bit of 5-htp to the l-theanine too - that has it's own twist.

 

[Esperighanto]

Try adding a bit of 5-htp to the l-theanine too - that has it's own twist.

5-HTP is an interesting one with LSD, melatonin and picamilon and L-theanine and vaporized L-DOPA all struck me as surprisingly heady adulterants to the LSD experience too. Beware the L-DOPA antics though, smoking some Mucuna pruriens extract damn near deleted me 4-5 years ago.

 

[pupnik]

I look at this https://www.erowid.org/chemicals/ghb/ghb_dose.shtml and imagine that it may be hard to be certain of staying in a safe zone while dosing.
while it is called a CNS depressant (gabaergic synapses do shut down ongoing circuits) it is also compared to MDMA which I regard as somewhat of a stimulant.
anyway maybe it is good in small amounts.

 

[Esperighanto]

I look at this https://www.erowid.org/chemicals/ghb/ghb_dose.shtml and imagine that it may be hard to be certain of staying in a safe zone while dosing.
while it is called a CNS depressant (gabaergic synapses do shut down ongoing circuits) it is also compared to MDMA which I regard as somewhat of a stimulant.
anyway maybe it is good in small amounts.

GHB's therapeutic index is lowkey a fucking public menace dude, be careful with it. I and a couple others I know have skirted by on abusing it like we're trying to catch a restraining order, but I have also met people who've suffered traumatic overdoses off of a dose that should've been well in the range of safety. It's a tricky one that also mimics endogenous neurotransmitters to a degree where I rarely advise it to people who are prone to redosing, that seems to be the slippery slope towards GHB toxicity.

 

[cnnka]

5-HTP is an interesting one with LSD, melatonin and picamilon and L-theanine and vaporized L-DOPA all struck me as surprisingly heady adulterants to the LSD experience too. Beware the L-DOPA antics though, smoking some Mucuna pruriens extract damn near deleted me 4-5 years ago.

I take L-Dopa,theanine,Tetrahydromagnolol and Kigelia with 7OH and it becomes really good heady high.

 

[Esperighanto]

I take L-Dopa,theanine,Tetrahydromagnolol and Kigelia with 7OH and it becomes really good heady high.

I've never heard of kigelia, how would you characterize it?

I found tetrahydromagnolol to potentiate benzodiazepines in an extremely unique way, but only ever tried it from a single source and just trusted that it was what it was, I was pretty young at that point.

 

[cnnka]

I've never heard of kigelia, how would you characterize it?

I found tetrahydromagnolol to potentiate benzodiazepines in an extremely unique way, but only ever tried it from a single source and just trusted that it was what it was, I was pretty young at that point.

Kigelia is pretty obscure yeah, and honestly I wouldn’t say it’s very psychoactive on its own. For me it’s more like a background thing slightly calming, smooths things out a bit, but nothing strong or distinct. It just makes the stack feel more rounded and less edgy.

About tetrahydromagnolol, I’ve heard that about benzos but can’t really confirm it. I usually take benzos after the stack wears off, not together, and I stay around 200–400mg, so maybe I just haven’t noticed it.

 

[Ismene2]

Gonna try choline next.

 

[KurtAurelius]

Gonna try choline next.

CDP is my shout if you want more mental effects Alpha GPC is more for the gym and physical energy.

CDP choline goes nice with Ritalin or Caffeine, I take 500mg twice a week due to it having a long half life like 2-3 days

ah another one If you have the choline with 15-20gs of creatine it’s feels like being freshly awake..

 

[Ismene2]

Its alpha gpc I've got - only heard of choline for the first time last week! Will check out CDP.

Im amazed by how much effect these legal supplements have on acid - altering the concentration of various neurotransmitters had never occurred to me before.

 

[KurtAurelius]

Its alpha gpc I've got - only heard of choline for the first time last week! Will check out CDP.

Im amazed by how much effect these legal supplements have on acid - altering the concentration of various neurotransmitters had never occurred to me before.

People wildy underestimate it for sure, you’ve got me wanting to trip lol, I still don’t think I can handle 12 hours of acid but definitely a gram or two of mushies

 

[KurtAurelius]

Ismene have you tried taurine and Agmatine?

Both gabaergic

Agmatine has the trippy serotonin receptor activity, 3 grams in my experience feels like 10mg of K as it’s also NMDA receptor antagonist.

Taurine increases GABA, just make sure to have simple carbs with, very good for adding loads of carbs to your daily intake and keeping you more mellow. I can get stoned and binge eat nightly and sit at 70kg lean at 5”11.

Tryptophan becomes serotonin from complex carbs. Pain Au Choclat is a fav of mine at this time of night

Or a bowl of cereal.

 

[Esperighanto]

Agmatine has the trippy serotonin receptor activity, feels like 10mg of K as it’s also NMDA receptor antagonist.

Maybe it was a bad source, I tried two sources but I couldn't get agmatine to feel like anything more than ~25mg of memantine, even in monstrous doses. I just attributed it to being a possible quirk of my own neurotypology though and moved on.

Taurine increases GABA, just make sure to have simple carbs with, very good for adding loads of carbs to your daily intake and keeping you more mellow. I can get stoned and binge eat nightly and sit at 70kg lean at 5”11.

This is fascinating, how does taurine exhibit metabolic effect? I've known people to use it similarly and have long been curious about it, hearing about it here on BL has reminded me of that curiosity.

 

[KurtAurelius]

Maybe it was a bad source, I tried two sources but I couldn't get agmatine to feel like anything more than ~25mg of memantine, even in monstrous doses. I just attributed it to being a possible quirk of my own neurotypology though and moved on.

This is fascinating, how does taurine exhibit metabolic effect? I've known people to use it similarly and have long been curious about it, hearing about it here on BL has reminded me of that curiosity.

Sorry dude know it’s lazy, I don’t actually know the mechanisms in depth rather than it achieves that effect. As I know you know your stuff, I’m a noob still lol

Effects and Mechanisms of Taurine as a Therapeutic Agent - PMC

Taurine is an abundant, β-amino acid with diverse cytoprotective activity. In some species, taurine is an essential nutrient but in man it is considered a semi-essential nutrient, although cells lacking taurine show major pathology. These findings ...

pmc.ncbi.nlm.nih.gov

Btw with Agmatine I’m extremely sensitive to all drugs I think because of my fucked up natural brain chemistry (Autism, ADHD, EUPD)

Your description sounds relatively still feasible for people used to higher doses of agents.

I should remeber to add a disclaimer about my own sensitivity.

 

[Esperighanto]

Sorry dude know it’s lazy, I don’t actually know the mechanisms in depth rather than it achieves that effect. As I know you know your stuff, I’m a noob still lol

Effects and Mechanisms of Taurine as a Therapeutic Agent - PMC

Taurine is an abundant, β-amino acid with diverse cytoprotective activity. In some species, taurine is an essential nutrient but in man it is considered a semi-essential nutrient, although cells lacking taurine show major pathology. These findings ...

pmc.ncbi.nlm.nih.gov

Btw with Agmatine I’m extremely sensitive to all drugs I think because of my fucked up natural brain chemistry (Autism, ADHD, EUPD)

Your description sounds relatively still feasible for people used to higher doses of agents.

I should remeber to add a disclaimer about my own sensitivity.

I appreciate the info and link here!

 

[SuperPsych]

Phenibut will always be the GABA drug that I add to LSD and any other psychedelic experience. I don't like alcohol. Benzos dull the trip for me and take away any sort of spiritual benefit (even at small benzo doses). Carisoprodol with Allylescaline I wasnt a huge fan of, would have preferred one or the other; though I know that @Esperighanto speaks highly of Soma+LSD. Amanita during the comedown of LSD is nice. GHB I have never used with a psychedelic, though I feel like it'd be too sedating. Thats why I like phenibut; anti-anxiety, non-sedating, and it doesnt take away from the trip at all.

I am a fan of L-Theanine. I have used it often for anxiety attacks and also to help get to sleep after a dissociative session. Don't think I've tried it with any psychedelic.

Haven't tried zopiclone or zolpidem with a psychedelic, either. Zopiclone might not be too bad. Zolpidem might be dangerous with how randomly people respond to it on its own

 

[Esperighanto]

Phenibut will always be the GABA drug that I add to LSD and any other psychedelic experience. I don't like alcohol. Benzos dull the trip for me and take away any sort of spiritual benefit (even at small benzo doses). Carisoprodol with Allylescaline I wasnt a huge fan of, would have preferred one or the other; though I know that @Esperighanto speaks highly of Soma+LSD. Amanita during the comedown of LSD is nice. GHB I have never used with a psychedelic, though I feel like it'd be too sedating. Thats why I like phenibut; anti-anxiety, non-sedating, and it doesnt take away from the trip at all.

I am a fan of L-Theanine. I have used it often for anxiety attacks and also to help get to sleep after a dissociative session. Don't think I've tried it with any psychedelic.

Haven't tried zopiclone or zolpidem with a psychedelic, either. Zopiclone might not be too bad. Zolpidem might be dangerous with how randomly people respond to it on its own

Specifically Soma and LSD seem to copotentiate for many (though not all) people who mix them, and we can't really figure out why. It didn't work for Shinji, but it's worked for 5 (was it 6? I'd have to check the notes) people here so far. It makes me wonder if the Indian Pain-O-Soma's I've used for the experiments have a contaminant that amplifies LSD, because it doesn't amplify phenethylamines or NBOMe/NBOH compounds but if something's indolic (tryptamines for example) it amplifies it.

 

[SuperPsych]

Specifically Soma and LSD seem to copotentiate for many (though not all) people who mix them, and we can't really figure out why. It didn't work for Shinji, but it's worked for 5 (was it 6? I'd have to check the notes) people here so far. It makes me wonder if the Indian Pain-O-Soma's I've used for the experiments have a contaminant that amplifies LSD, because it doesn't amplify phenethylamines or NBOMe/NBOH compounds but if something's indolic (tryptamines for example) it amplifies it.

Interesting, so you seem to be saying that Carisoprodol enhances the LSD experience? In what ways, if you are able to elaborate? That's a good point about the Pain-O-Soma's. As we've discussed elsewhere, Indian Pain-O-Soma seems inconsistent in potency, and yeah, who knows how what additives/fillers might interact? Or maybe it's more an interaction with meprobamate?

Well shiet, next time I drop acid I may have to take some soma. Was thinking about tripping this weekend anyways since I have 3-me-pcp. Maybe I'll do a LSD+3-Me-PCP+Soma. What is your timing with the carisoprodol when combining it with LSD? I assume the soma is taken towards the end of the trip and in doing so you get an uptick in psychedelia?

 

[Ismene2]

Hopefully gonna have the chance tomorrow to try some acid with Alpha gpc (to increase acetylcholine) and maybe 3-400mg of 5-htp to increase serotonin. Prob throw in some l-theanine to increase GABA. Will report back.