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  • BDD Moderators: Keif’ Richards

Lybalvi - another anti depressant that causes opioid precip withdrawl

notsmokeymcpot42088

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I believe this is the second antidepressant that has been compounded with /naloxone/naltrexone for as a PREVENTATIVE AGAINST A POSSIBLE SIDE EFFECT --- of Weight Gain?

Bold prediction -- you will be seeing more and more of this unless some kind of stand is taken now.

Or was Lybvalvi the same one I was talking about last time? ---- Sorry it is an immediate red flag to me.

Anyone in the medical field have any valid reason why we throwing this shite into anti depressants?
 
yea that is the same article alright.

"Weight loss" is not what the medication is for.

Weight gain is a POSSIBLE SIDE EFFECT of Olanzapine.....

Critical thinking time -- We really think they are adding samidorphan because they are worried about us (US) being overweight??

So back to the question -- Why would they be putting that shit into Olanzapine?

(Could take a step back and say Olanzapine itself is often not used in good faith)
Thorazine Zombies for 10 Alec!
 
Weight gain is a side effect associated with many antipsychotics.

I don't understand your beef with this...

Do you have sand in your vagina? 😁
 
Weight gain is a side effect associated with many antipsychotics.

Side effects do not apply to everyone correct? So you mean common side effect.

I don't understand your beef with this...

Do you have sand in your vagina? 😁

You don't understand why one may be concerned about opiate antagonists being needlessly added to an SSRI/anti-psychotic? As a pro rights harm reductionist at least.

1. What percent of people are on some type of SSRI or antipsychotic? (If it sticks to just lybvaldi, I guess I dont care - this sets a precedent to other SSRI/Medications in general...)
2. There are a hundred better options than an opi antagonist for combating weight loss
3. I do not believe that being on an anti depressant means you should not be able to take opiates; do you?
4. When have they ever been worried about American's being obese? I do not see any naltrexone in the cheeseburgers?
 
Why is this a problem?

More of a redflag than problem. It would be a problem if you were on opiates and got prescribed lybvaldi though -- to combat the possible side effect of weight gain? *Listen to side effects (Of most meds), weight gain is about as good as its gunna get.

Why put anyone in that situation. I am just not buying the logic honestly.
 
More of a redflag than problem. It would be a problem if you were on opiates and got prescribed lybvaldi though -- to combat the possible side effect of weight gain? *Listen to side effects (Of most meds), weight gain is about as good as its gunna get.

Why put anyone in that situation. I am just not buying the logic honestly.
Doctors ask patients if they are using opiates before prescribing them anything containing an opiate antagonist such as naltrexone.
 

1. What percent of people are on some type of SSRI or antipsychotic? (If it sticks to just lybvaldi, I guess I dont care - this sets a precedent to other SSRI/Medications in general...)
2. There are a hundred better options than an opi antagonist for combating weight loss
3. I do not believe that being on an anti depressant means you should not be able to take opiates; do you?
4. When have they ever been worried about American's being obese? I do not see any naltrexone in the cheeseburger
1 about 14-17%
2 bupropion is allredy an anti depressant so it could be too much, peptides (such as ozempic) are expensive, naltrexone is both cheap and does'nt have cross interactions with anti depressants (note that in 5% of the population it does cause depression, in which case another medication would be prescribed)
3 anti depressants dont work in combination with drugs
4 obesity is le bad for your health and worsens depression.
 
My psychiatrist offered me LyBalVi as an alternative to invega. It would come in pill form.
I stood my ground in saying I want none of it. neither invega nor lybalvi.
I don't want a stockpile of pills I have to get rid of.
 
They should throw in a statin too as Olanzapine causes a raise in blood-lipids like Cholesterol and Triglycerides which is the leading cause of coronary heart disease. I don't know why but this often gets overlooked which can be a fatal mistake for a lot of people!
 
I am not that familiar with Olanzapine but I am against compounding "Active ingredients" in prescrition medication... Period.

@ions it worries me a little bit how often we seem to land in a camp of exactly 2. Still pretty sure we onto something based on your last thread though.

From the tylenol in hydros (That the FDA banned but remains there), the prometh in codeine syrup, the naloxone in suboxone (even though it does nothing). --- All shitty deals for the patient (Big money for big pharma dumping product with NO DEMAND we end up paying for).

Do you appreciate any of these compounds?

@blazR Since you didn't dismissively link a wiki article I will indulge you as best I can --- Ephedrine. weight loss drug (And you get a bit of energy; I would argue *All day* that lethargy is a more problematic and common side effect of anti-psychotics than weight gain)
 
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1 about 14-17%
Thank you for obliging me.

Taking opiates away from 17% of the population could have it's advantages --

2 bupropion is allredy an anti depressant so it could be too much, peptides (such as ozempic) are expensive, naltrexone is both cheap and does'nt have cross interactions with anti depressants (note that in 5% of the population it does cause depression, in which case another medication would be prescribed)

Noone mentioned buproprion. "Expensive" hmm where is sumidorphan is I am going to guess absolutely demand less until now? I am more concerned with peoples health than finances when it comes down to it.

Don't compound the Olanzapine and offer the patient a choice? That sounds like a better option for everyone....(except whoever is selling the sumidorpphan I suppose) If not please explain why.

3 anti depressants dont work in combination with drugs

That was not an answer to the question with all due respect. Most medications interact with another medication - this is not an unusual phenomenon.

Sumidorphan is not an anti depressant either -- but it does have a side effect of depression (as do most anti depressants so grain of salt)

I have to take that as a "No I do not believe people prescribed anti depressants should be allowed opiates" until clarified.

4 obesity is le bad for your health and worsens depression.

So you are believe they put sumidorphan (sp) in altruistically? Lookin to buy any timeshares by chance ...

I agree and am avidly anti obesity --- on the side effect scale compared dick not working and permanent cognitive fog. Strange priorities.

Now I know I answered flippantly to both of you but I genuinely appreciate the input and feedback. Really THANK YOU FOR ANSWERING THE ?'s and I will be sure to address any of your points as well as I can.
 
Thank you for obliging me.
NP
Taking opiates away from 17% of the population could have it's advantages --
Well i personnally am against opiates due to my father being addicted to heroin but i think they should give anti depressants that dont contain MU-opiate antagonists to opiate users.
Noone mentioned buproprion. "Expensive"
Yes but Bupropion could cause harmfull side effects.
hmm where is sumidorphan is I am going to guess absolutely demand less until now?
[?]
I am more concerned with peoples health than finances when it comes down to it.
Of course, however this would stop financially strained people from accessing certain anti depressants in countrys like the US.
Don't compound the Olanzapine and offer the patient a choice? That sounds like a better option for everyone....(except whoever is selling the sumidorpphan I suppose) If not please explain why.
Well that's natural of course, i do believe a choice is offered to the patients.
That was not an answer to the question with all due respect. Most medications interact with another medication - this is not an unusual phenomenon.
I dont have an answer, you are correct however i dont understand the point of this argument.
Sumidorphan is not an anti depressant either -- but it does have a side effect of depression (as do most anti depressants so grain of salt)
I dont have an answer, you are correct however i dont understand the point of this argument.
I have to take that as a "No I do not believe people prescribed anti depressants should be allowed opiates" until clarified.
I do believe opiate users should be allowed anti depressants however using opiates greatly reduce the effects of anti depressants and they should attempt to get sober for opiates for their anti depressants to be truely effective.
So you are believe they put sumidorphan (sp) in altruistically? Lookin to buy any timeshares by chance ...
I dont understand this sentence.
I agree and am avidly anti obesity --- on the side effect scale compared dick not working and permanent cognitive fog. Strange priorities.
Everybody has different side effects, personnally my libido has come back and the brain fog dissapeared very quickly.
Now I know I answered flippantly to both of you but I genuinely appreciate the input and feedback. Really THANK YOU FOR ANSWERING THE ?'s and I will be sure to address any of your points as well as I can.
Thank you too, i must admit i have a hard time understanding some of your points but i greatly appreciate your ability to have a civilized argument (a rare trait which i associate with intelligence).
 
Yes but Bupropion could cause harmfull side effects. -

So why use buproprion - there are a ton of weight loss drugs that are not opiate antagonists.

[?]

Of course, however this would stop financially strained people from accessing certain anti depressants in countrys like the US.

Well that's natural of course, i do believe a choice is offered to the patients.

That is all I ask, the patient gets a choice between the compounded version or just olanzapine. As long as this is all by choice I really don't have too much concern.

I dont have an answer, you are correct however i dont understand the point of this argument.
There is no point in arguing. There are choices that do not have such interaction problems and this just feels like a cheap way for someone to dump sumidorphan or w/e into a compound that not only doesn't need to exist -- even if it it did there are better weight loss options I am still convinced...
I dont have an answer, you are correct however i dont understand the point of this argument.
same point; noot really an argument. I just don't like big pharma capitalizing on a product with no demand -- especially when alot of the people precribed olanzapine probably dont want to be. Adding an opiate antagonist feels like spiting an already captive group of people.

If they can opt for plain olanzapine and it is cheaper -- this argument does become somewhat moot. I would ask can they opt for plain olanz and is it cheaper?

I do believe opiate users should be allowed anti depressants however using opiates greatly reduce the effects of anti depressants and they should attempt to get sober for opiates for their anti depressants to be truely effective.
Fair enough. I believe that statement carries some bias against opiates which is very understandable giving your situation.

From such I would infer you are against things like MDMA/Ketamine therapy? Morphine (Objectively) tends to be a pretty good anti depressant when used alone and left alone --- it got the "Gods Own Medicine" title for good reason.

Going to morphine for depression is somewhat akin to going to sumidorphan for weight loss in my mind. Sure it is AN option --- is it anywhere near the best option? if doctors started doing that regularly I would have to wonder if there wasnt some bigpharma $$ behind it....

good enough metaphor!
I dont understand this sentence.
I was asking if you believe they truly added sumidorphan for the benefit of patient's and not they bank account --- given I find the metaphor above roughly on par it seems like long odds to me.

Everybody has different side effects, personnally my libido has come back and the brain fog dissapeared very quickly.

I am VERY GLAD to hear that -- I am not personally on any of these medications but know plenty of ppl who are / have been etc ... and weight loss was DEFINITELY DOWN THE LIST under not being able to "Finish" -- if start at all in bed and whether they were aware or not (Usually were) it felt like blunting cognitive abilities -- which is needed sometimes?? It is a highly questionable practice to me.
Thank you too, i must admit i have a hard time understanding some of your points but i greatly appreciate your ability to have a civilized argument (a rare trait which i associate with intelligence).

No problem. Truly thank you for taking the time to address what ya could. PS dont feel like you gotta address every question again (feel free to of course) but I think other than this last thing we are on about as common ground as people are likely to reach having fully formed opinions and all.

--- I guess my only real remaining concern is that the compound is indeed optional and you wouldnt be looked at askew or charged more for saying "Nah leave that shite out of my medication please" or that it is indicative of future trends in the SSRI/antpyschotic market at large.

I think Ions should get opiates if he wants them personally -- spose that is subjective though haha
 
I believe this is the second antidepressant that has been compounded with /naloxone/naltrexone for as a PREVENTATIVE AGAINST A POSSIBLE SIDE EFFECT --- of Weight Gain?

Bold prediction -- you will be seeing more and more of this unless some kind of stand is taken now.

Or was Lybvalvi the same one I was talking about last time? ---- Sorry it is an immediate red flag to me.

Anyone in the medical field have any valid reason why we throwing this shite into anti depressants?
Seem s worse then reformulating a Opioide with a laxative. Oxycontin 80 mg/ 10 gram Macrogol. Got Oxycodone once and Macrogol came on a seperate prescription along ? Assuming constipation prevention that is already weird [they don t have that effect on me]. But was consulted with me and i declined it.

Body s differ like minds. Are they gonna add Naltrexone to Mirtazepine, Pregabaline, Benzo s and medical Weed to. These all also can cause weight gain. Hey maybe better add a stimulant Methylphenidate or d-[Meth]Amphetamine, If they might get the munchies that might help even better.

No no no way totally get it and why you posted. Medically seen at least separate after evaluating if this side effect occurs Even then this sound as Fluoridating the water kinda. Unwanted medicating but with something that will have multiple impact s. Among precipitated WD. doesn t feel like the best option to me.

Any idea how the consult go with the patient. "Well we added a bit of the antidote for Heroin and Fentanyl Od s, just in case to manage possible weight gain. " Oath of Hippocratus do dr s do that https://en.wikipedia.org/wiki/Hippocratic_Oath
 
From such I would infer you are against things like MDMA/Ketamine therapy?
I 100% approve of MDMA/ketamine therapy, i really just have a distain for opiates (i believe opiate pain killers/anesthetics should be replaced with cannibanoids and NMDA antagonists like ketamine).
-
I dont really have much else to answer seeing as while we disagree on opiates we do agree that big pharma should not be forcing opiate antagonists onto consumers.
 
At least in the UK, the PIL will describe potential side-effects thus:

Common Side Effects - a side-effect more then 10% of users may experience although it may go on to state that a side-effect is transient
Rare Side Effects - a side-effect more than 0.1% of users will explerience but may go on to state a side-effect is transient
Uncommon Side Effects - a side-effect experienced by less than 0.1% of users but if experienced, a clinician should be consulted.

That last one is to cover idiopathic symptoms, allergies to the medicine and/or excipients.

Serious Side Effects -a patient should stop taking the medication and seek clinical advice as soon as is reasonably possible.

That last catagory automatically results in the clinician sending a Yellow Card Warning to the MHRA who in turn will contact both the manufactuer and clinician(s).

I was aware of samidorphan and indeed used it to demonstrate how a phenolic -OH could be substituted with a carboxamide moiety - it increases duration of action. I sort of assumed it would be somewhat like naltrexone i.e. a high-affinity non-selective opiate receptor antagonist. I worried about the seeming increase in prescribed naltrexone to treat opiate misuse disorder. The reason being that dysphoria is a common side effect. If it blockades the reward pathways, a person cannot experience happiness. Thus, when combined with post-AWS depression, it could pose a risk of a patient self-harming (or worse).
 
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