naltrexone rebound and use in the opioid naive

[Neuroprotection]

sorry if this has been discussed before, but I was wondering if there is any sort of rebound effect when stopping high dose long-term naltrexone. i’ve read one anecdote claiming that it created a natural but strong opioid high but I doubt this happens in most people.
I once read an article warning that stopping naltrexone after long-term use can cause reward hypersensitivity to alcohol and certain other drugs but unfortunately, I can’t find the article to post here.
This makes me wonder, as a person who has never tried opioids, what would happen if I took a high dose of naltrexone(50 to 100 mg) daily for a month or so and then stopped?
I’d love to know if anyone has tried this, especially if they had never used opioids
Thanks in advance.

 

[Neuroprotection]

Just for a bit more context, my intention isn’t to get an opioid high, but rather to enhance dopaminergic function, motivation and stress resilience. however, more than that, it’s just something I want to do out of curiosity

 

[Neuroprotection]

I’m really surprised this got no replies, does no one have any experience with this?

 

[darkFrozenLight]

I've tried the same thing as an experiment with both a one time dose of 50mg and then with a taking this for a length of time. This was over 10 years ago so I don't remember the specifics, but I experienced nothing after the one time dose or continual dosing. However, I'm one of those people who doesn't experience any negative effects from nalterxone, I know some people experience dysphoria while taking it so things might be different for them.

Also, I remember reading something (but maybe I'm misremembering) that naltrexone in the presence of no agonists acts like a very mild opiate agonist and this is why people sometimes get withdrawals from taking it for a length of time especially with low dose natrexone doses (1-5mg).

 

[Skorpio]

Don’t have the time for a full answer, but idk if naltrexone completely works its positive effects via reversing receptor down-regulation

It has some very beneficial effects on microglia via toll like receptor 4 antagonism, so if look toward that to answer your question .

 

[Neuroprotection]

Don’t have the time for a full answer, but idk if naltrexone completely works its positive effects via reversing receptor down-regulation

It has some very beneficial effects on microglia via toll like receptor 4 antagonism, so if look toward that to answer your question .

From reading many studies about aboutthe MU receptor, I got the impression that this receptor has many modulatory effects on neurons that have nothing to do with its traditional direct signal in pathway. if I remember correctly, it can form complexes with other receptors and might have some control over dopamine surface receptor expression.
What I found really fascinating is that MU receptors might be required for the experience of both positive and negative emotions, for example in response to music.

Anhedonia to music and mu-opioids: Evidence from the administration of naltrexone - Scientific Reports

Music’s universality and its ability to deeply affect emotions suggest an evolutionary origin. Previous investigators have found that naltrexone (NTX), a μ-opioid antagonist, may induce reversible anhedonia, attenuating both positive and negative emotions. The neurochemical basis of musical...

www.nature.com

 

[N0ph0n0]

Wow... this morning i did'nt take my naltrexone (i am seeing a girl today and naltrexone makes me too antisocial and also it makes me fart so much) and i feel high, i have only had an opiate once (fent) when i went to the dentist to get my tooth remove and this feels similar, better but weaker, allmost orgasmic, dreamy, just good.

 

[N0ph0n0]

Wow... this morning i did'nt take my naltrexone (i am seeing a girl today and naltrexone makes me too antisocial and also it makes me fart so much) and i feel high, i have only had an opiate once (fent) when i went to the dentist to get my tooth remove and this feels similar, better but weaker, allmost orgasmic, dreamy, just good.

Update, not taking my naltrexone did not create the high it just brought back the high i used to feel when i started to use venlafaxine, it also makes the caffeine high stronger and nicotine more pleasurable.