What would you combine mdma with if you could press your own xtc?

[HeadphonesandLSD]

I notice a lot of people here are saying they'd add caffeine into the mix. Any particular reason?

A lot of people initially got introduced to MDMA through pressed tablets before the ability to buy pure MDMA was as common as it is now. They attribute the good feelings they got from MDMA initially in part to the fact that it was often mixed with caffeine and various other speedy substances (like a small bit of meth or amphetamine).

I've found there are generally two types of drug users: Those that prefer uppers and those that prefer downers. Those that prefer uppers seem to be a larger portion of the population. For them adding some speed to the mix makes it more fun and is nostalgic to their initial introduction to the substance.

I've never liked speed mixed with MDMA. I prefer MDMA (or MDA) by itself because I find it more relaxing and chill than the speed combo. If anything I prefer a bit of downers (like a mild opioid) with my MDMA to calm the sometimes rocky first alerts. MDMA/MDA can be very unsettling when first effects start before you settle into the roll itself and start getting to the peak. I'm sure you know what I mean. That 10-15 minute period where you feel like your heart might explode, you're strapped to a rocket, the nausea and the anxiety before the good effects set in shortly after. I try to calm that down with a mild opioid. Other people seem to burst through that initially with a mild stimulant.

In my experience there are also two types of MDMA users. I'm one of the people that like to take it and chill. A lot of people only want to dance and be very active. The latter group are the ones that enjoy a bit of speed with their MDMA. Which is why it was so common to find it in pressed tablets being sold at live events and clubs. Since the vast majority of people there that were buying it intended to use it as a social aide to help them get out on the dance floor. MDMA/MDA by itself can be kind of sedating in the right setting or even in a setting that usually isn't conducive to chilling out and sitting around. The little bit of stimulant can be the push that is the difference between getting stuck in the corner rolling alone or out on the dance floor.

 

[SotPoker1012]

A lot of people initially got introduced to MDMA through pressed tablets before the ability to buy pure MDMA was as common as it is now. They attribute the good feelings they got from MDMA initially in part to the fact that it was often mixed with caffeine and various other speedy substances (like a small bit of meth or amphetamine).

I've found there are generally two types of drug users: Those that prefer uppers and those that prefer downers. Those that prefer uppers seem to be a larger portion of the population. For them adding some speed to the mix makes it more fun and is nostalgic to their initial introduction to the substance.

I've never liked speed mixed with MDMA. I prefer MDMA (or MDA) by itself because I find it more relaxing and chill than the speed combo. If anything I prefer a bit of downers (like a mild opioid) with my MDMA to calm the sometimes rocky first alerts. MDMA/MDA can be very unsettling when first effects start before you settle into the roll itself and start getting to the peak. I'm sure you know what I mean. That 10-15 minute period where you feel like your heart might explode, you're strapped to a rocket, the nausea and the anxiety before the good effects set in shortly after. I try to calm that down with a mild opioid. Other people seem to burst through that initially with a mild stimulant.

In my experience there are also two types of MDMA users. I'm one of the people that like to take it and chill. A lot of people only want to dance and be very active. The latter group are the ones that enjoy a bit of speed with their MDMA. Which is why it was so common to find it in pressed tablets being sold at live events and clubs. Since the vast majority of people there that were buying it intended to use it as a social aide to help them get out on the dance floor. MDMA/MDA by itself can be kind of sedating in the right setting or even in a setting that usually isn't conducive to chilling out and sitting around. The little bit of stimulant can be the push that is the difference between getting stuck in the corner rolling alone or out on the dance floor.

Meth or amphetamine would definitely tip the roll in favor of being speedy. I just find that caffeine in particular, except perhaps at high doses which poses its own issues, would be entirely overshadowed by the MDMA once the roll properly begins. I've had coffee during an mdma comeup and it didn't seem to do much, except maybe make the comeup a bit more edgy. (higher heart rate/noticing it more mainly)
It makes sense that the caffeine thing would be mainly nostalgia for their first rolls at clubs, etc.

I lean heavily towards downers, but MDMA and related drugs are by far my favorite. Do you find that opioids change the roll at all? During my opioid addiction, I usually spaced my dose out from the MDMA so that the peak effects would be ending by the time the MDMA kicked in, basically balancing withdrawals and the potential for a blunted roll. Eventually I moved to kratom and I've taken it close to my MDMA before, with no noticable impact.

Personally I find MDMA to be "calming" but not "sedating" by itself. It relaxes me, makes me a bit dreamy, kinda like that feeling one gets when they're a kid and they were allowed to stay up way past their bedtime. However I can't actually go to sleep on it, at least not without introducing a downer or sleep aid. Not that I would want to waste a roll by going to sleep!

I'm definitely in the "take it and chill" camp, but I'm autistic and introverted, so there is no combination of drugs that would make me comfortable in a party with more than a handful of people. Combined with the fact that MDMA makes me emotional, I really don't think I'd enjoy taking it at a club, myself, though I definitely understand why its considered a party drug. Personally I take it alone or with a small group of people that I know pretty well. (Girlfriend, usually - sometimes our close friends) The most physical activity I like to get up to on MDMA is going for a walk. Admittedly sometimes quite long ones.

MDA, even though it feels more stimmy to me, actually gives me pretty bad couch lock whereas MDMA does not. I toss it up to 5ht2a agonism.

 

[N0ph0n0]

The things I would do to add MDAI to my collection..

I notice a lot of people here are saying they'd add caffeine into the mix. Any particular reason? MDMA is quite stimulating in its own right, far moreso than a regular dose of caffeine. I've drank coffee (roughly one cup = 100mg of caffeine) while waiting on MDMA to kick in, and by the time it did, any effect from the caffeine was overshadowed. I tend to find MDMA calming and stimulating at the same time, it didn't seem to effect that. It might've made the come up a bit more edgy.

Is it just nostalgia for peak xtc tab days where caffeine was added to the mix as filler, or do you guys find it actually improves the roll?

It's a nice little boost/filler, and it helps masks the horrible taste of amphetamines. Im a the more the better type of guy (first time i did molly i had bought 0.6g and taken it all within 6-8 hours) so i want the strongest high no matter what, i hate the feeling of just sitting on couch on a roll, i want to run at mack 5 towards my dealer because i need another bag of crystal, i want to get in a fist fight with who ever is down to throw fists, i want to feel the adrenaline pump through me, i want to tweak harder than everyone else, i want to be biggest methed up giant who's presence scares people.

 

[SotPoker1012]

It's a nice little boost/filler, and it helps masks the horrible taste of amphetamines. Im a the more the better type of guy (first time i did molly i had bought 0.6g and taken it all within 6-8 hours) so i want the strongest high no matter what, i hate the feeling of just sitting on couch on a roll, i want to run at mack 5 towards my dealer because i need another bag of crystal, i want to get in a fist fight with who ever is down to throw fists, i want to feel the adrenaline pump through me, i want to tweak harder than everyone else, i want to be biggest methed up giant who's presence scares people.

It sounds like you'd prefer straight up methamphetamine over Molly tbh

But they might be a nice mix together for somebody like you.

When I was at my most degen with MDMA, I ended up taking a whole gram over 12 hours. It didn't really amp me up.

I'm guessing you aren't a fan of 5-mapb if you've tried it. It's the least stimulating empathogen I've tried.

 

[Esperighanto]

20mg of DOM? Jesus Christ.

I'm kind of a freak when it comes to loving high doses of psychedelics, 90mg of intranasal DOM was my highest dose so far, it was during an MDMA bender.

75mg MDMA with 25mg of meth, 50mg dextro amphetamine, 50mg MDA, 100mg caffeine. Shaped like a xanny bar but with the letters MOLLY instead.

This would be maybe the most fascinating mix of common stimulants I can think of outside of AMPAkines (noopept, racetams, etc.) and reuptake inhibitors.

I notice a lot of people here are saying they'd add caffeine into the mix. Any particular reason? MDMA is quite stimulating in its own right, far moreso than a regular dose of caffeine. I've drank coffee (roughly one cup = 100mg of caffeine) while waiting on MDMA to kick in, and by the time it did, any effect from the caffeine was overshadowed. I tend to find MDMA calming and stimulating at the same time, it didn't seem to effect that. It might've made the come up a bit more edgy.

I always coadminister caffeine with any monoamine releaser to keep the headaches away, but I'm also savagely addicted to caffeine.

I'm guessing you aren't a fan of 5-mapb if you've tried it. It's the least stimulating empathogen I've tried.

I've only run into 5-MAPB once but it's my favorite empathogen, it's what MDMA should be in therapeutic contexts imo.

 

[SotPoker1012]

I've only run into 5-MAPB once but it's my favorite empathogen, it's what MDMA should be in therapeutic contexts imo.

I've only tried it once, but I'm planning a combo roll with it tonight and mdma. So far with only one experience, I may well like it more than MDMA. Its definitely close and it fits my "style" of rolling quite well, as I like to chill and get all overly emotional on these drugs. (VS partying) I need to play with it more to truly rank it.
I'm hoping taking a low dose of MDMA will give it more of a dopaminergic edge while maintaining the key qualities of 5MAPB.

It had moments that felt almost opiate like, which I really appreciated.

 

[N0ph0n0]

It sounds like you'd prefer straight up methamphetamine over Molly tbh

But they might be a nice mix together for somebody like you.

When I was at my most degen with MDMA, I ended up taking a whole gram over 12 hours. It didn't really amp me up.

I'm guessing you aren't a fan of 5-mapb if you've tried it. It's the least stimulating empathogen I've tried.

My substance of choice is indeed crystal meth, however this is more due to how it allows me to function as a member of society. Effects wise i like molly more because it makes me feel high while meth makes me feel sober but hyped/happy. Biggest problem i have with molly is how quickly tolerance is built up.

 

[SotPoker1012]

My substance of choice is indeed crystal meth, however this is more due to how it allows me to function as a member of society. Effects wise i like molly more because it makes me feel high while meth makes me feel sober but hyped/happy. Biggest problem i have with molly is how quickly tolerance is built up.

You may be ADHD or something similar. I haven't tried meth, myself, but I've taken amphetamine before and I get near zero recreational value. It makes me feel more sober than when I am actually sober, just with increased focus and mental clarity. Meanwhile some of my friends seem to get really high from high dose amphetamine.

Definitely agree on molly. The only downside is quick tolerance buildup and rapidly increasing negative symptoms with increased use. It may also have perma tolerance which is a bit scary. If I could take it every day, I would.

 

[N0ph0n0]

You may be ADHD or something similar. I haven't tried meth, myself, but I've taken amphetamine before and I get near zero recreational value. It makes me feel more sober than when I am actually sober, just with increased focus and mental clarity. Meanwhile some of my friends seem to get really high from high dose amphetamine.

Definitely agree on molly. The only downside is quick tolerance buildup and rapidly increasing negative symptoms with increased use. It may also have perma tolerance which is a bit scary. If I could take it every day, I would.

Yup i have a severe case of ADHD, when i say severe i mean to the point that if it was'nt for my spatial intelligence being far above average along with my slightly above average linguistic skill than i would have been considered mildly retarded because of how bad my results on the attention tests were when i got a psychiatric evaluation.

 

[Allylbenzene]

...what people on here would put in their ecstasy if they were in charge of mixing and pressing them?

For built-in tolerance prevention, hangover prevention and general MDMA potentiation (so a dose is ~twice as strong):

(In one pill)
- MDMA
- low-dose theanine (~25mg)
- low-dose magnesium (~50mg, not glycinate)
- low-dose niacinamide (10-50mg)
- low-dose thiamine (10-50mg)
- low-dose riboflavin (5-10mg)
- very low-dose aspirin (5-15mg)
- very low-dose pregnenolone (1-5mg)

The context for those items is in this post.

 

[Esperighanto]

For built-in tolerance prevention, hangover prevention and general MDMA potentiation (so a dose is twice as strong):

(In one pill)
- MDMA
- low-dose theanine (~25mg)
- low-dose magnesium (~50mg, not glycinate)
- low-dose niacinamide (10-50mg)
- low-dose thiamine (10-50mg)
- low-dose riboflavin (5-10mg)
- very low-dose aspirin (5-10mg)
- very low-dose pregnenolone (1mg)

The context for those items is in this post.

Is there any peer reviewed literature supporting these? I'd imagine that if we were to go by peer reviewed literature instead of what we arbitrarily wanted the real answer would be something like escitalopram, 5-MAPB and propranolol, but I often hear of things like niacinamide, thiamine, riboflavin, and pregnenolone being touted as positives for bouncing back from a heavy roll but I've never seen that actually substantiated.

 

[Allylbenzene]

Is there any peer reviewed literature supporting these? I'd imagine that if we were to go by peer reviewed literature

Going by the literature we'd find only that they increase the NAD/NADH ratio, OXPHOS, BDNF, steroidogenesis and tyrosine hydroxylase activity amongst other things. It's up to the reader to make the connection between the function & role of said things and their actual biological effects.

...the real answer would be something like escitalopram, 5-MAPB and propranolol

Comparatively this assortment seems lacking. The SSRI class as a whole is rather crude imo. Propranolol is interesting as it mildly blocks some 5-HT receptors.

...there is evidence that indicates propranolol acts as a relatively weak antagonist of certain serotonin receptors, namely 5-HT1a, 5-HT1b and 5-HT2b.

(–)-Propranolol is not a silent antagonist of the 5-HT1a receptor but is instead a very weak partial agonist.

 

[Phobos]

If these were just for me? 20mg of DOM, 75mg of MDMA, 15mg of miprocin (4-HO-MiPT), and 12mg of 3-HO-PCP. Giving one of those to somebody who didn't know what was in it though would make MKUltra look like a nice treat.

20mg DOM is a bit of a heroic dose isn't it? Surely going to be active for over 24hours?

 

[Phobos]

Is there any peer reviewed literature supporting these? I'd imagine that if we were to go by peer reviewed literature instead of what we arbitrarily wanted the real answer would be something like escitalopram, 5-MAPB and propranolol, but I often hear of things like niacinamide, thiamine, riboflavin, and pregnenolone being touted as positives for bouncing back from a heavy roll but I've never seen that actually substantiated.

Wouldn't and SSRI kick MDMA off from SERT, altering the effects?

 

[Allylbenzene]

Wouldn't an SSRI kick MDMA off from SERT, altering the effects?

Looking beyond SERT, an SSRIs' impact on the entire serotonin system would broadly undermine the MDMA experience imo. The idea that increasing serotonin using an SSRI is good for recreational value (or recovery) is short-sighted as things are more nuanced. Imo SSRIs are worthy for the bin unlike the botanical SRIs.

 

[Allylbenzene]

I prefer MDMA (or MDA) by itself because I find it more relaxing and chill

MDA ... actually gives me pretty bad couch lock whereas MDMA does not.

Imo this is due to alpha-2 adrenergic agonism. α2-adrenergic agonists are known to cause sedative effects (see clonidine) and MDMA was found to activate α2A. This would likely contributes to it's therapeutic benefits.

Alpha-2 adrenergic agonists are able to produce sedation, analgesia, euphoric effects and partially block acute withdrawal symptoms in chronic opioid users.

Adding an α2-adrenergic to a sedation regimen reduces opioid requirement by 50–75% and benzodiazepine requirement by upwards of 80%.

https://doi.org/10.2344/0003-3006-62.1.31

 

[Mjäll]

The things I would do to add MDAI to my collection..

My friends took it once and the were smacking each other with bats, laughing and crying with joy

I don't remember why i declined

 

[Allylbenzene]

They attribute the good feelings they got from MDMA initially in part to the fact that it was often mixed with caffeine and various other speedy substances (like a small bit of meth or amphetamine).

I'd place caffeine in an entirely different class to other stimulants as it operates quite differently. It's more of a metabolic stimulant which also blocks serotonin receptors, mainly 5-HT1 & 2. The issue is that an assessment of a drugs effects seems limited to the receptors it interacts with - so an academic will tend to assume that caffeine's effects are solely due to it's receptor interactions.

Here's some context for the anti-serotonin effects (blocking a receptor tends to unregulate it aka increase density):

• Chronic ingestion of caffeine by male NIH strain mice alters the density of a variety of central receptors.
• The density of cortical A1 adenosine receptors is increased by 20%, while the density of striatal A2A adenosine receptors is unaltered.
• Densities of striatal D1 and D2 dopaminergic receptors are unaltered.
• The densities of cortical 5-HT1 and 5 HT2 serotonergic receptors are increased by 26–30%.
• Densities of cortical muscarinic and nicotinic receptors are increased by 40–50%. The density of cortical benzodiazepine-binding sites associated with GABAA receptors is increased by 65%, and the affinity appears slightly decreased.

From https://pubmed.ncbi.nlm.nih.gov/8242688/

 

[HeadphonesandLSD]

I'd place caffeine in an entirely different class to other stimulants as it operates quite differently.

I'm not a fan of it myself when mixed with MDMA. But consider this: The vast majority of people are caffeine addicts with a high tolerance. But everyone tells newbies to avoid drinking anything but water when consuming MDMA. So a little bit of caffeine helps people avoided the dreaded caffeine withdrawal headaches. Which I'm sure most would attribute to whatever pressed XTC tablet they were consuming and not the fact that they ceased consuming a drug they're taking daily.

I can see the logic behind it.

The vast majority of people have no idea what they're talking about when it comes to XTC tablets in the first place. I've heard about people claiming one press was "heroin based" and the next "cocaine based" and blah blah blah so much over the years. I'm not sure why such people are so confident while talking completely out of their ass. But they really believe that shit.

 

[lost weekend]

A female I could cuddle into and speak shite when I'm coming up and same when I'm on my way down