Tryptamines 5-f-met bretisilocin

[Keeloverandfly]

Just acquired some of this. While it seems to be promising—there is a ton of money in it’s development—there are practically no trip reports (only 2 recent ones on Reddit to this day, surely due to it recently being put on the market in Europe) Any brave souls here try it?

 

[tuppingtoncity]

We need more good reports on this substance for sure, it would be lovely if you might provide one! although i understand hesitance fs, however seems to be a pretty interesting one at least pharmacokinetically

 

[TheLightBringer]

Just acquired some of this. While it seems to be promising—there is a ton of money in it’s development—there are practically no trip reports (only 2 recent ones on Reddit to this day, surely due to it recently being put on the market in Europe) Any brave souls here try it?

Please post reports, I made a post about it on reddit about a year back when it was completely new.

Although a part of me wants this substance to be somewhat gatekept as its still in medical trials, and someone misusing it could be bad publicity and ruin its chances of becoming a medication. Its binding profile looks great with it being a 5ht2b antagonist in contrast to agonist, minimizing heart toxicity and risk of valvulopathy.

I think this one has a great shot at becoming a proper medication

 

[TheLightBringer]

Although regarding its recreational effects its a balanced 5ht2a and 5ht2c agonist, and has a 1,5h duration (however I think that was IV). But it sounds like an amazing short acting psych, ive always wanted a psych thats longer acting than DMT but shorter than the 4-subbed trypts so you can dose high and enjoy the trip for longer than DMT but not have to commit to half a day like other tryptamines

 

[emkee_reinvented]

Not me, got a brave soul the NPS act just makes it ... harder. What is the expectation ?
Of the 5-F not gonna expect it behaves like predicted. Seems bit akin to 5-Meo.

4-HO-MIPT was ime the gentlest vs 5-Meo-MIPT. Took 4-HO-MET and have 5-Meo-DIPT laying around which top s in physical unhappiness. ..

 

[Keeloverandfly]

Please post reports, I made a post about it on reddit about a year back when it was completely new.

Although a part of me wants this substance to be somewhat gatekept as its still in medical trials, and someone misusing it could be bad publicity and ruin its chances of becoming a medication. Its binding profile looks great with it being a 5ht2b antagonist in contrast to agonist, minimizing heart toxicity and risk of valvulopathy.

I think this one has a great shot at becoming a proper medication

I didn’t see your post on reddit… was it the research chems sub? Was it a trip report or just documentation?

I will likely hold off on taking it because I’m waiting for others to report back. Hopefully there’s no shortage of foolhardy young souls willing to do the dirty work… but maybe curiosity will get the better of me!

 

[Keeloverandfly]

Although regarding its recreational effects it’s a balanced 5ht2a and 5ht2c agonist, and has a 1,5h duration (however I think that was IV). But it sounds like an amazing short acting psych, ive always wanted a psych thats longer acting than DMT but shorter than the 4-subbed trypts so you can dose high and enjoy the trip for longer than DMT but not have to commit to half a day like other tryptamines

yes all the clinical trials use IV. But aren’t most IV tryptamines shorter durations than oral? Wouldnt oral use just extend the duration? I ain’t stickin no needle in my arm, I have too many vein health problems to risk adding another one.

 

[TheLightBringer]

I didn’t see your post on reddit… was it the research chems sub? Was it a trip report or just documentation?

Just a documentation

I will likely hold off on taking it because I’m waiting for others to report back. Hopefully there’s no shortage of foolhardy young souls willing to do the dirty work… but maybe curiosity will get the better of me!

I mean the fact that its currently in human trials bodes well for its safety. Ill see if I can dig up some of the research papers, they ought to have some mention of dosage

 

[TheLightBringer]

yes all the clinical trials use IV. But aren’t most IV tryptamines shorter durations than oral? Wouldnt oral use just extend the duration? I ain’t stickin no needle in my arm, I have too many vein health problems to risk adding another one.

Yes IV will be significantly more rapid onset and peak and quicker dropoff. Im guessing oral might be something like a 3 hour duration

Still sounds promising with only 3 hour duration, less risk of an intense trip going south by lasting too long.

You could try vaporizing it, that ought to be somewhat similar to IV in regards to onset and duration, what salt form is it in?

 

[Keeloverandfly]

Yes IV will be significantly more rapid onset and peak and quicker dropoff. Im guessing oral might be something like a 3 hour duration

Still sounds promising with only 3 hour duration, less risk of an intense trip going south by lasting too long.

You could try vaporizing it, that ought to be somewhat similar to IV in regards to onset and duration, what salt form is it in?

Unfortunately I don’t vape or smoke anymore (my dmt has been untouched for two years), because I get bronchitis almost systematically. I will ask about the salt form though anyways, as they didn’t indicate on the site.

I actually really like longer trips. If they are bad and I can’t figure it out, benzos to the rescue! But I am still very curious about this one even if it is shorter.

 

[Speak Easily]

PATENTED. Abbvie controls and owns the patent for Bretisilocin with an investment of over $1,000,000,000. If you make the mistake of impeding this research or purchasing this chemical without proper authorization expect to speak with a lawyer!

AbbVie to Acquire Gilgamesh Pharmaceuticals' Bretisilocin, a Novel, Investigational Therapy for Major Depressive Disorder, Expanding Psychiatry Pipeline

Gilgamesh's lead asset, bretisilocin (GM-2505), is a potential best-in-class psychedelic compound currently in Phase 2 development for the treatment of major depressive disorder (MDD)....

news.abbvie.com

 

[TheLightBringer]

PATENTED. Abbvie controls and owns the patent for Bretisilocin with an investment of over $1,000,000,000. If you make the mistake of impeding this research or purchasing this chemical without proper authorization expect to speak with a lawyer!

AbbVie to Acquire Gilgamesh Pharmaceuticals' Bretisilocin, a Novel, Investigational Therapy for Major Depressive Disorder, Expanding Psychiatry Pipeline

Gilgamesh's lead asset, bretisilocin (GM-2505), is a potential best-in-class psychedelic compound currently in Phase 2 development for the treatment of major depressive disorder (MDD)....

news.abbvie.com

Mate nobody is going to be sued by gilgamesh for using this recreationally despite their 1,2 billion dollar patent.

Youll just catch a regular drug charge depending on your countrys laws

 

[Speak Easily]

My understanding, from the current research in the United States and in the Netherlands, is that this medicine is a atypical psychedelic with limited recreational potential. Earlier research showed reduced oral bio-availability with undesirable side effects necessitating clinical administration via IV injection for optimal therapeutic effect. Furthermore, the visual effects only appear to be apparent at higher doses based on research conducted in Leiden University Medical Center in The Netherlands. Given proper administration high doses are well tolerated and the treatment is highly effective at sustainably reducing the symptoms of major depressive disorder.

Phase three trials are ongoing.

 

[TheLightBringer]

My understanding, from the current research in the United States and in the Netherlands, is that this medicine is a atypical psychedelic with limited recreational potential. Earlier research showed reduced oral bio-availability with undesirable side effects necessitating clinical administration via IV injection for optimal therapeutic effect. Furthermore, the visual effects only appear to be apparent at higher doses based on research conducted in Leiden University Medical Center in The Netherlands. Given proper administration high doses are well tolerated and the treatment is highly effective at sustainably reducing the symptoms of major depressive disorder.

Phase three trials are ongoing.

The part that interested me the most about it was that it showed anti OCD effects in animals in the form of reduced marble burying. And the 5HT2B antagonism makes me hopeful for reduced cardiotoxicity

 

[Keeloverandfly]

The part that interested me the most about it was that it showed anti OCD effects in animals in the form of reduced marble burying. And the 5HT2B antagonism makes me hopeful for reduced cardiotoxicity

i hope that is true, I bury too many marbles these days.

 

[Keeloverandfly]

PATENTED. Abbvie controls and owns the patent for Bretisilocin with an investment of over $1,000,000,000. If you make the mistake of impeding this research or purchasing this chemical without proper authorization expect to speak with a lawyer!

AbbVie to Acquire Gilgamesh Pharmaceuticals' Bretisilocin, a Novel, Investigational Therapy for Major Depressive Disorder, Expanding Psychiatry Pipeline

Gilgamesh's lead asset, bretisilocin (GM-2505), is a potential best-in-class psychedelic compound currently in Phase 2 development for the treatment of major depressive disorder (MDD)....

news.abbvie.com

I’m shaking in my boots!

 

[xdrc]

The part that interested me the most about it was that it showed anti OCD effects in animals in the form of reduced marble burying. And the 5HT2B antagonism makes me hopeful for reduced cardiotoxicity

I'm skeptical of it truly being an antagonist, probably partial agonist but that may be enough to reduce harm compared to full agonists. I don't think it matters too much with irregular use anyways.

It is plenty active nasally so it does not need to be i.v.'ed, and I'd bet it is orally active too (with reduced B.A.) and decent at that.

From the reports of the material we have so far (analytically unconfirmed) it does seem like it has recreational potential by either nasal or inhalative application.

 

[pupnik]

nasal for me

 

[TheLightBringer]

I ended up finding this:

https://www.reddit.com/r/researchchemicals/s/TcLgx6QkCO

Although I would have liked a bit more description about the character of the visuals, but I guess with the comparisons to 4-HO-MET and DMT one can try to form an idea.

 

[perpetualdawn]

I think this is the molecule we're talking about here https://en.wikipedia.org/wiki/Bretisilocin, 5-meo-met. Can't remember if that has turned up as an RC in the past anywhere before this patent etc. 1 billion seems like an awful lot to spend for something like this, I wonder if that figure is expanded in order to impress via shell-game bookkeeping? How could you spend that much on something like this? I get that proper drug trials and lawyers can be expensive, but that expensive?