It seems most at people are ignorant when it comes to drugs

[Innerpeace]

Today a buddy and I were texting, and I was telling him four months ago I stayed up for four nights, with only two days or less hours of sleep each night or twenty four hour period

Im a younger middle aged guy, he is an older adult at seventy three. In the past year he’s had one shoulder replacements, and two knee replacements

Doctors he sees gave him seroquel, which ai says is atypical antipsychotic medication used to treat schizophrenia, bipolar disorder, mania and depression, and sometimes majors r depressive disorder, used in teens thirteen and older. It works on 5ht1a and 5ht2, and dopamine ,d1and d2 to stabilize mood

Then it has the warning on the label that says may cause suicidal thoughts in children and young adults

A doctor recommended four different drugs, and my parents said okay. I went though intense and negative emotional feelings for months while on them. Thankfully I was only in them for six months from fourteen to fifteen years. All that said, doctors prescribe serious mind altering drugs, and buddy would give me it for sleep

I told him , after I googled it, said i dont want to introduce new drugs into my system. The less drugs the better, and I have expirimented with a lot, and they definitely work

Is what people do with microdosing lsd, and psilocybin , similar to what this drug seroquel is prescribed for, desiring the same serotonin system’s elevation, causing us to feel happier for the next day and maybe few days ?

Well buddy recommended for sleep, he can’t take it bc it causes his legs to cramp, so some doctors seem to prescribe it ignorantly

My my guess is sero stands for serotonin

 

[Electrum1]

It's prescribed off-label in lower doses for insomnia. Maybe that's why he's prescribed it and the dose prescribed to him is low. Sounds like he was just sharing his personal experience with you

Not staying up for 4 days would probably eliminate the need for this post. So that's something to think about not doing again

 

[Innerpeace]

It's prescribed off-label in lower doses for insomnia. Maybe that's why he's prescribed it and the dose prescribed to him is low. Sounds like he was just sharing his personal experience with you

Not staying up for 4 days would probably eliminate the need for this post. So that's something to think about not doing again

Why would 5ta1a , 5hta2, d1 and d2 be used for sleep?


Gaba a and to some extent gaba b class drugs are best for sleep, ,no?


Yes, I don't plan on doing that again. If it takes finding a different sleep drug , so be it. That said, decarbed CBD has helped a lot with deeper restful , more relaxing demeanor before and after sleep, the it wears off

Btw ssris ssnis these antidepressants antipsychotic drugs are shown that be really bad long term

 

[Electrum1]

I was just saying that maybe the 73 year old wasn't thinking about it as in depth as you currently are, so he was probably just sharing the info he knows from being told by his doctor about what he's prescribed

 

[Innerpeace]

I was just saying that maybe the 73 year old wasn't thinking about it as in depth as you currently are, so he was probably just sharing the info he knows from being told by his doctor about what he's prescribed

I think everyone needs to know the information available then blindly trust a guy that achieved their doctorate degree. Why wouldn’t you want to have some knowledge of what brain chemicals the drug works on. Moreover, many boomers still believe the doctor knows best, without doing research on the drugs

It seems this type of thinking stopped more so with Gen X. Maybe im wrong, hopefully so

My brother and I have recommended to dad to research before taking the drug. Dad seems to take whatever the dr prescribes vs having a drug you found through researching online that seems to be best for you , at the time. This is what happened thirty years ago when he and mom let sea put me on four different experimenting with adhd drugs. Hopefully Im wrong about him and he does research drugs he puts into his system bc he takes quite and maybe a lot

Many doctors are known to recommend drugs the company provides samples for this first, I know bc I worked in a doctors office , then end up automatically prescribing drugs of their choice

You are correct buddy was trying to help, and he can’t take it, bc it cause lower legs to cramp really bad. He thinks he’s figuring the leg cramps out , bc it’s been going on for many years

 

[BadBoy377]

You could have stopped that thread title after seven words.

 

[streaM Freak]

Is what people do with microdosing lsd, and psilocybin , similar to what this drug seroquel is prescribed for, desiring the same serotonin system’s elevation, causing us to feel happier for the next day and maybe few days ?

Seroquel, in my experience, helped with depression simply because it greatly reduced my irritability. It doesn't specifically target the serotonin receptors.

And for dopamine, it doesn't increase it, it actually does the opposite.

So if you are not manic, psychotic, or having sleep trouble, there is really no point, in my opinion.

 

[Innerpeace]

Seroquel, in my experience, helped with depression simply because it greatly reduced my irritability. It doesn't specifically target the serotonin receptors.

And for dopamine, it doesn't increase it, it actually does the opposite.

So if you are not manic, psychotic, or having sleep trouble, there is really no point, in my opinion.

It targets 5htp1a, 5htp2 partially 1a receptors through its metabolite. Blocks 2a strongly. This serotonin effect can increase mood , anxiety, and indirectly increase dopamine in the prefrontal cortex ( thinking , mood area of the brain)

Targets D1 and d2, mainly d2 which reduces excessive dopamine signaling. However it binds weakly and releases quickly so dopamine can still function

Buddy takes a medicine for Parkinson's. We worked together for five years , his hands used to shake much more than current. I would think Seroquel wouldnt be good since it attaches strong to d2, causing dopamine signaling to slow down, it's very common for elderly patients to be taking drugs that could counteract effects, and at that age , the doctor does not know or does not care, I'm going back assume they don't know

I haven't studied this drug in depth so I don't know, this one s the first say I've heard , well seen through text, about this drug

If not had to guess, mixing seroquel with a drug for Parkinson's, would not mix because this works on the d2 receptor reducing excessive dopamine signaling , which the Parkinson's drug , pramipexole is used for Parkinson's and restless leg syndrome or leg cramps as he called them.

Thankfully this drug seems to be working for him and it makes sense when he took Seroquel his legs would cramp due to reduced dopamine signals or signaling

 

[streaM Freak]

It targets 5htp1a, 5htp2 partially 1a receptors through its metabolite. Blocks 2a strongly. This serotonin effect can increase mood , anxiety, and indirectly increase dopamine in the prefrontal cortex ( thinking , mood area of the brain)

Targets D1 and d2, mainly d2 which reduces excessive dopamine signaling. However it binds weakly and releases quickly so dopamine can still function

Buddy takes a medicine for Parkinson's. We worked together for five years , his hands used to shake much more than current. I would think Seroquel wouldnt be good since it attaches strong to d2, causing dopamine signaling to slow down, it's very common for elderly patients to be taking drugs that could counteract effects, and at that age , the doctor does not know or does not care, I'm going back assume they don't know

I haven't studied this drug in depth so I don't know, this one s the first say I've heard , well seen through text, about this drug

If not had to guess, mixing seroquel with a drug for Parkinson's, would not mix because this works on the d2 receptor reducing excessive dopamine signaling , which the Parkinson's drug , pramipexole is used for Parkinson's and restless leg syndrome or leg cramps as he called them.

Thankfully this drug seems to be working for him and it makes sense when he took Seroquel his legs would cramp due to reduced dopamine signals or signaling

If it works it works, but tell him to stay attentive to any changes. When i went from 200mg to 300mg i got restless legs and could not sleep.

It seems like seroquel is more for the mental health aspect of Parkinsons. A drug like Cogentin (which is usually taken with other antipsychotics like Haldol) would be more for movement, i'm pretty sure.

 

[MedicinalUser247]

The maximum dose is Quetiapine 800mg. Bedtime. Which would also be the maximum dose per-day. So, there's a lot different ways to take it depending on what's right for you. I've heard a few people complain about Restless Leg Syndrome from only a few people. The funny thing about Quetiapine is that it acts much more like a Sedative instead of an Antipsychotic. This is because it acts heavily on the H1-histamine receptors in the Brain and it has a lower effect on the D2 and 5-HT2A receptors compared to other Atypical Antipsychotics and Neuroleptics.

 

[notsmokeymcpot42088]

most ppl are ignorant to most fields that aren't there forte'

Dont be ignorant when you enter a new field

 

[MedicinalUser247]

most ppl are ignorant to most fields that aren't there forte'

Dont be ignorant when you enter a new field

Tell me about it. Doctors are totally off guard when I ask them why I want to be put on a Medication and What I'm using it for. It's like Hello... I need these Meds to keep myself sane.

 

[notsmokeymcpot42088]

I saw the commercial and it told me to ask you for this drug--- Here's I am -- tell me why its a bad idea??

Shitty spot for doctors to be in --- but the pharma ads direct to consumers kind of ruins any "How do you know about that" type of recourse.

lol if you can get them to believe it was their decision not yours bonus points

 

[Innerpeace]

I’d rather experiment with microdosed lsd than take a script drug for mood, and it does seem to work some

The most profound drug thats seemed to lift depression immediately is ketamine, r, or possibly other dissociatives. Fxe was okay but r k seemed to help more

The reason why ketamine clinics keep it there is because people will overuse and abuse it. Even when someone is mentally disciplined and has a stash of dissidents it’s easy to do it and improve mood

I question do people really need it or can use it as much as they do. I haven’t had any in four months now due to being ripped off from a site. I don’t know how to do bitcoin, habit figured it out yet, use to get it though credit card, and the fact life costs money and I ask myself do I really need it?

For depression it’s been shown to use every 3 to 4 days , the first few weeks maybe month then once a week then once every two weeks then stop for a while. Basically what ketamine clinics do for depression, and of course it’s 300$ an injection

 

[Allylbenzene]

Doctors he sees gave him seroquel
...so some doctors seem to prescribe it ignorantly

A doctor recommended four different drugs, and my parents said okay.

Imo these observations are fairly justified.
What makes doctor's such terrible drug distributors for corporate healthcare?

• They don't appreciate the full extent of possible side-effects from their drugs.
• They fail to educate patients on the real impact of their drugs.
• They don't fully understand how their drugs work biologically.
• They regularly commit acts of medical negligence but tend to not recognise they have done so - and so offer zero remedial action to mitigate their ignorance.
• They aren't trained to understand the importance of diet.
• They have a limited range of approved drugs to work with.
• Their drugs all have side-effects. Often the primary action of the drug causes the negative effects so calling them "side"-effects is misleading.
• They are legally required to follow guidelines which promote only their suppliers drugs.
• They are trained by their suppliers who "mould" their educational & training material, both directly & indirectly.
• Their suppliers have sales targets, a marketing team and a legal team to manage lawsuits.
• They don't appreciate the extent of fraud & misdirection in the scientific arena where their drugs originate and are "proven" to work based on manicured statistics & specially crafted academic studies.
• In some countries they receive financial incentives for prescribing certain drugs, either directly or indirectly.

 

[Innerpeace]

Imo these observations are fairly justified.
What makes doctor's such terrible drug distributors for corporate healthcare?

• They don't appreciate the full extent of possible side-effects from their drugs.
• They fail to educate patients on the real impact of their drugs.
• They don't fully understand how their drugs work biologically.
• They regularly commit acts of medical negligence but tend to not recognise they have done so - and so offer zero remedial action to mitigate their ignorance.
• They aren't trained to understand the importance of diet.
• They have a limited range of approved drugs to work with.
• Their drugs all have side-effects. Often the primary action of the drug causes the negative effects so calling them "side"-effects is misleading.
• They are legally required to follow guidelines which promote only their suppliers drugs.
• They are trained by their suppliers who "mould" their educational & training material, both directly & indirectly.
• Their suppliers have sales targets, a marketing team and a legal team to manage lawsuits.
• They don't appreciate the extent of fraud & misdirection in the scientific arena where their drugs originate and are "proven" to work based on manicured statistics & specially crafted academic studies.
• In some countries they receive financial incentives for prescribing certain drugs, either directly or indirectly.

Great information on what makes doctors terrible distributiors of drugs .

I believe the psychiatrist made a mistake expirementing with me with four different drugs. All I was told was to take this, they're supposed to help

I was fourteen years old, recently moved away from Ne Maryland to Nw Tennessee. Dad was a pastor, super strict, no tv allowed in house, and other rules. I broke the rules and this is the reason for Parents sought counseling from a psychiatrist,and psychiatrist recommend this drugs. I wasn't told of any effects. It did change my brain chemistry to the point I would cry , and before this i didn't do this. I would compare this to or it be akin to, two days after a way too high mdma dose. Finally I became property of the State for a few months and thankfully was given back to parents and taken off all drugs that gave me

Adolescent minds are not equipped enough to handle the negative effects in my experience

I feel it programmed my brain chemistry at too young of an age to know how these mind drugs behave, and potentially caused me to try other serotonin drugs like patches to feel that feeling again. I didn't do them untill age 35 and lad untill after age forty Ime the drugs at age fourteen and fifteen caused me to act differently. I feel way too many adolescent s and children are out on these drugs and effects their brain chemistry far too early in. I think twenty five is a good age to decide whether one wants to begin possibly expirementing with psyche drugs or after that age bc the brain is about fully mature then

 

[BadBoy377]

Great information on what makes doctors terrible distributiors of drugs .

I believe the psychiatrist made a mistake expirementing with me with four different drugs. All I was told was to take this, they're supposed to help

I was fourteen years old, recently moved away from Ne Maryland to Nw Tennessee. Dad was a pastor, super strict, no tv allowed in house, and other rules. I broke the rules and this is the reason for Parents sought counseling from a psychiatrist,and psychiatrist recommend this drugs. I wasn't told of any effects. It did change my brain chemistry to the point I would cry , and before this i didn't do this. I would compare this to or it be akin to, two days after a way too high mdma dose. Finally I became property of the State for a few months and thankfully was given back to parents and taken off all drugs that gave me

Adolescent minds are not equipped enough to handle the negative effects in my experience

I feel it programmed my brain chemistry at too young of an age to know how these mind drugs behave, and potentially caused me to try other serotonin drugs like patches to feel that feeling again. I didn't do them untill age 35 and lad untill after age forty Ime the drugs at age fourteen and fifteen caused me to act differently. I feel way too many adolescent s and children are out on these drugs and effects their brain chemistry far too early in. I think twenty five is a good age to decide whether one wants to begin possibly expirementing with psyche drugs or after that age bc the brain is about fully mature then

Wow. That's quite an experience your younger self had to live through.

I don't have anything practical to say, just that I feel for you. I hope life is treating you better now.

BB

 

[Froglet]

I don’t like drugs and my psych thinks this drug is super
She’s a locum and instead of exploring why I’m not convinced she’s a nice but broken record. I think it’s making me worse.

 

[Innerpeace]

What happens for example with ketamine esp but last, magic mushrooms is the brain is changed with glutamate , and or default brain network, and if you change your thoughts during a certain time period, during and after the experience, since the brain is mailable to change, you can kind of program a new system of beliefs.

They say write things out in a hour al or maybe use techniques like reframing , which I find chatgtp seems to already do. This time would be the best time , even thinking about a situation different .

On the other hand if the same ruminating thoughts occur, it can make depression and thoughts of hopelessness worst

Ive always wondered I know these are tools for making things seem different or better, and does doing then without having to do inner work any benefit?

Regardless this is why I like to take Break and sometimes long breaks from all these mind changing things messing with the default mode network, or glutamate, as if there's no need, there's no need, and working toward something takes preference for a while

 

[TheUltimateFixx]

While the training of doctors obviously covers drug effects and interactions, the main focus is on diagnosis. If you want someone that knows all the minutiae of every counter-indication and side-effect, you want a pharmacist. There's a reason pharmacology is a specialty. The only thing is the pharmacist isn't licensed to prescribe.