Opium became illegal through a series of national and international laws between 1905 and 1920. The U.S. began federal bans with the 1909 Smoking Opium Exclusion Act - Canada passed the first Opium Act in 1908, Britain restricted it under the 1920 Dangerous Drugs Act, and international prohibition was solidified by the 1912 Hague Convention.
Marijuana became illegal in Canada in 1923 by being added to the Opium and Drug Act. While the U.S. began state-level bans earlier (e.g., California in 1915), federal prohibition came later via the
Marihuana Tax Act of 1937. Prohibition in the Western world developed around the same time, often linked to international treaties.
Mescaline was officially made illegal in the United States in 1970 when it was categorized as a Schedule I hallucinogen under the Comprehensive Drug Abuse Prevention and Control Act.
Cocaine was effectively made illegal in the United States by the Harrison Narcotics Tax Act of 1914, which heavily restricted its sale and distribution. Prior to this, it was widely used in products like Coca-Cola before 1903 and was restricted at the state level, with Georgia passing the first ban in 1902.
Naturally occurring psychotropic substances have not always been illegal.
Synthetic versions are equivalent to natural but may lack the "
entourage effect" of whole plant and crude plant extracts.
The Mumbo Jumbo about Natural Substances having Spirit Teachers connected with them is only as true and you make believe. Not that there is anything wrong with make believe, but it gets in the way after a while, and is fake to begin with.