chemconnoisseur
Greenlighter
- Joined
- Feb 20, 2026
- Messages
- 29
Opioids and Libido
Two of my absolute favorite things are sex and opioids. Unfortunately, especially as one uses opioids more regularly, these two don’t mix particularly well. This is going to be long, so I’ll have a TL;DR at the end. Apologies in advance, this is mainly male-focused, but I do have a female section at the end. I some have knowledge on ameliorating this to share, but I really really enjoy both nodding and having extreme horniness, so I’d like more input. If you have anything that works, shoot it at me! Whether it’s an add-on drug, a supplement, or a lifestyle change share your secret sauce (maybe poor choice of words for this topic
)Problem 1: TESTOSTERONE AND YOUR BALLS
I’ll try not get too into this, it’s both the most blatant and the easiest to fix, but also one of my fixations. Opioids bind in the hypothalamus, which leads to decreased LH production, LH being the main signal for your balls to do their thing (produce testerosterone and other steroidal compounds). Keep in mind that testosterone itself isn’t the only hormonal factor in libido, so while injecting test alone will increase libido, it won’t fully get you back to normal. Keep in mind that testosterone itself will completely nuke LH levels and shut down your balls. HCG is a very similar compound to LH that can be on top of testosterone will keep the levels of other neurosteroids and various hormones that regulate libido at, or even above, baseline. On top of this, it (can) maintain fertility and makes the processes of getting off of testosterone much easier. Enclomiphene can directly raise LH, and therefor testosterone and neurosteroids, but unfortunately it has a great deal of side effects and people rarely report feeling as good as they do injecting testosterone. It’s also more expensive anyways. So unless you’re deathly afraid of self-administering intramuscular shots, then just get on testosterone.
Solution 1: Honestly, if you’re on opioids, just get on TRT (preferably with HCG). Your entire life will get better, almost guaranteed. Most people with opioid addictions are hypogonadal and will easily be able to get testosterone prescribed after having their bloodwork drawn. If your levels are at 3-500, you might not get a script but should still take testosterone. It’s cheap and easy to get, there’s no excuse. Remember to add HCG for optimal efficacy. If you have the money to do opioids, you have the money to spend maybe $50 a month on everything you need to be in tip top hormonal shape. You also should probably get frequent bloodwork done to make sure you’re healthy and your levels are dialed in, but honestly at 250mg or lower testosterone is just going to amplify preexisting issues, it shouldn’t really cause any. More isn’t always better. Play with the dosages (with a doctor hopefully) and see what level makes you feel best.
Problem 2: PROLACTIN
Yep. The titty milk hormone. You’ve got it too. And probably a lot of it if you like opioids. Opioids suppress dopaminergic firing in the
tuberoinfundibular pathway that regulates prolactin. This is one of the reason that opioids make it hard to orgasm, it’s not just through numbness, it’s hormonal. Prolactin’s effects are bit less straightforward, reducing libido in a slightly complex way, all you need to know is that opioids increase it and it decreases sexual motivation.
Solution 2: This one is perhaps the trickest because there isn’t a safe single answer for what will work. B6 works on paper, but I’m yet to see people get meaningful increases from libido. Really what you need is a D2 agonist like cabergoline or pramiplexole, both of which are very strong drugs in their own right and have serious side effects and withdrawals (see: Dopamine Agonist Withdrawal Syndrome (DAWS)) I wish I had a better answer for this one, but I don’t, frankly. If you are going to try one of this I implore you to start as low and as infrequently as possible. Raising dopamine in general will lower prolactin and is much easier/safer, which leads perfectly into the next section.
Problem 3: DOPAMINE
Dopamine is never the problem, it’s the solution. Well at least in this case. Dopamine is in essence a, maybe even THE, prosexual molecule. And of course opioids dysregulate it. This one is even more complex than prolactin, has so many different receptors, and massive number of pathways and structures of the brain that it impacts (ie VTA, Nucleus Acumbens, PFC, are all distinct parts of the brain that utilize dopamine in different ways to exert its overall prosexual effect) so I’m not even going to attempt to make a stab and it and will
instead jump right into…
Solution 3:
Stimulants. Yeah they work and make you horny. We all know this. But, the goal of this thread is to help people’s sex lives, not create poly-addictions. There are plenty of natural ways to increase dopamine that you’ve all heard, but we’re all just hear for the drugs. One of my absolute favorites for this is a gem called 9-me-bc, it’s nootropic if you like to throw around that term that has a very unique mechanism by which it repairs, restores, and upregulates dopamine. It causes the growth of new dopaminergic neurons, which is super cool. I think it’s an invaluable tool to everyone, especially those of use who partake in recreational drugs, since those tend to mess up dopamine just a little bit lol. It usually takes a week to start working and should’ve run for a maximum for 3 months at a time. I’ve heard of it completely curing people’s anhedonia due to PAWS or other substance abuse related issues. Another fantastic drug is Selegiline, which increases dopamine through MAOb inhibition. This is particularly of note because lots of the toxicity associated with heavy dopaminergic load comes from the breakdown of dopamine, not dopamine itself. Selegline also has some addiction methods through which its neuroprotective, which makes it a pretty fair choice. Being an MAO-B inhibitor (not nearly as dangerous as full MAOi’s that inhibit both MOA-A and MAO-B, most risk comes from inhibiting A), it does have a certain number of interactions you should be aware of, start low and slow with anything. Bromantane is another nootropic that increases Tyrosine Hydoxylase in order make the brain produce more dopamine. It seems to work best when administered nasally. Has a ton of great effects other that just raising TH, but I’m getting ahead of myself. I could keep listing drugs in this section forever, but alas, I need to move on.
For the Ladies: You have hormones too! And dopamine obviously, anything from the dopamine section applies to you too. You might even need TRT! Testosterone isn’t just a male hormone, females need it to, especially for libido. Drugs can mess up the endocrine system and make you feel like shit. Take the initiative, get a full metabolic/hormone panel, and get any abnormalities corrected. I’m telling you, hormones are everything. You can’t be living your best life with your endocrine system out of whack.
Extra Drugs/Miscellaneous
Tadalafil/sildenafil (Cialis/Viagra) - Doesn’t technically increase libido on its own, but does increase blood flow to the penis or clitorous which can make every go much smoother
GHB - High high high risk especially with opioids. However it is an extremely prosexual drugs, my guess being that it is in part due to it increasing allopregnanolone, which I’ll get to later. Interestingly, GHB causes an initial reduction in dopamine, before a subsequent rebound as the drug wears off.
Phenibut - Similar to GHB, somewhat a cross between that and gabapentin/pregabalin (both could be mentioned here as well kinda), but a bit less risky, more dopaminergic, and much more clearheaded. Personally it’s probably my favorite drug of all time, and the social effects (lower anxiety, more confidence) make the sexual benefits a little easier to experience lol. I actually lost my virginity on this one.
PT-141 - A new peptide that works for both men and women to increase libido and sexual performance, lasts for like a full day so you may be uncomfortably hard at times. The main side-effects are nausea and flushing, the nausea can be quite bad, although I haven’t experienced that. There are some case reports of it causing lasting anhedonia out of nowhere, so it may be best to tread lightly. I’d keep use to once a week if possible.
Allopregnanolone - This is a really interesting one. It’s a neurosteroid that’s heavily implicated in sexual functioning, both directly in a certain way, and indirectly disinhibiting dopamine in the nucleus acumbens, and by increasing oxytocin. It also functions as a GABA PAM, similar to benzos, although I don’t believe there’s evidence of tolerance. Neuroprotective as well, it’s damn near perfect. It’s basically impossible to find and difficult to administer, so it’s only currently used to treat postpartum depression in an IV solution called Brexanolone. A new orally active anlog called zuranolone was semi-recently approved by the fda for post partum depression, hopefully we’ll see some cases of off-label use soon, although if I’m not mistaken it is a Class IV drug in the US.
TL;DR
Alright you lazy fucks, here’s just the fun stuff. Please do full and proper research before trying absolutely anything. Basically your HPTA is shut down so you have no testosterone or neurosteroids, your prolactin is as high as you are, and your dopamine is… well… complicated. Here’s the list of drugs for each of these issues
Testosterone - Testosterone (duh)
Prolactin - Only options are somewhat risk (cabergoline and pramiplexol)
Dopamine - 9-me-bc, selegiline, bromantane
Thanks For Reading!
