Opioids Transitioning from 7-OH to O-DSMT

[chemconnoisseur]

Hey y’all. Long time lurker here that finally made an account, this’ll be my first post.

Over the last month or two I’ve been 7-OH more frequently than I typically would, in the last two or weeks it became a daily habit in high dosages. I haven’t kept track of the dosage exactly, but I’d ballpark it at 300-400mg assuming the shitty gas station tablets I buy are properly dosed. For the sake of my wallet, health (I find 7-OH to be quite suspicious and imagine it’s more damaging than pharma opioids, despite being a partial agonist), tolerance, stability in dosing, and personal preferences, I’ve decided to switch over to O-DSMT, which brings me to the topic of this post.

I’ve heard a number of people discuss kratom and its alkaloids having a dulling, or straight out muting, effect on full MOR agonists that have a lower binding affinity. My other concern is that because 7-OH is a high affinity partial agonist, my tolerance may make O-DSMT much less worth while. I will definitely take at least a 12h break from 7-OH before starting O-DSMT. I’m also considering taking a longer break if the tolerance build up is extreme enough to justify it. I have SR-17018 and pregabalin along with a wide variety of supplements and peptides on hand, so withdrawals aren’t a major concern. The problem is that I’m trying to be very sparing with both SR-17018 and pregabalin. I’ve heard SR can become less effective when used multiple times and would rather save it for when I plan on being off of all opioids for an extended time. As for pregabalin, it’s just one of my favorite drugs and I love it too much to risk “losing the magic” lol. Anyways, back to the question.

Based on your experiences, which of the following would be the best route to take?
1. Immediately transition from 7-OH to O-DSMT (w:/ a 12+ hour break)
2. Take a 2-3 day break with SR-17018
3. Go a full week off to get rid of tolerance with SR-17018

 

[daturetard]

Why do you assume 7 oh is more dangerous than pharmacy opioids? Its been used (albeit not in your doses) by humans for hundreds if not thousands of years indirectly, as Mitragynine naturally oxidizes, and metabolizes into it in the liver

 

[chemconnoisseur]

Why do you assume 7 oh is more dangerous than pharmacy opioids? Its been used (albeit not in your doses) by humans for hundreds if not thousands of years indirectly, as Mitragynine naturally oxidizes, and metabolizes into it in the liver

It’s an extremely high binding affinity partial agonist, so it wrecks tolerance mainly. The other issue is that we don’t know what all it does pharmacologically other than just mu partial agonism. We know that kratom itself has effects beyond just mu, which makes withdrawals and interactions a bit more intense, whether or not 7-oh itself if a pure partial agonist we have no clue. Although the reports of withdrawal seem far more intense than classical opioids, and I’ve seen a few horror stories of people developing wild side effects like numbness and skin issues (blistering, acne, puss) that you don’t see with pharmas, which have a full century of scientific literature on them. I’m not knocking 7-oh by any means, it’s quite a euphoric drug and certainly has its place, but for me personally the price, insane tolerance, lack of full opioid euphoria, and potential risks make it less appealing than pharma opioids.

 

[chemconnoisseur]

Okay so as a general update to this for any future lurkers, I decided to just get on subs (trialing around 6-8mg) after the most agonizing week of my life going through 7-oh withdrawal (crazy since I was only on it for 2-3 weeks) and haven’t tried my new o-dsmt yet. They seem to help a bit, but I’m too explorative, so I’ll continue to use certain opioids. I’ve been on for a few days, before learning that a) 7-oh breaks through suboxone and b) it only takes like 3 days off for you to be able to feel opioids again. So I decided tonight that I’m going to use 7-oh for the next two or so days while the buprenorphine clears out, and give it 36-72 hours of no bup and 12 hours of no 7-oh. I’ll post another update just for general information, even though this situation now is a bit different than the original post.